PubRank

David J A Wyllie

Author PubWeight™ 45.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 2008 4.04
2 Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol 2005 2.90
3 Glutamate receptor gating. Crit Rev Neurobiol 2004 2.31
4 Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A 2012 2.14
5 The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron 2012 1.97
6 Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission. Mol Pharmacol 2006 1.59
7 Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci 2008 1.58
8 Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol 2007 1.56
9 Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization. J Physiol 2009 1.41
10 Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. J Neurosci 2010 1.39
11 Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. J Neurosci 2005 1.33
12 Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nat Commun 2013 1.30
13 Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br J Pharmacol 2006 1.29
14 Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One 2009 1.24
15 Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol 2007 1.24
16 Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Mol Pharmacol 2005 1.20
17 The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Hum Mol Genet 2006 1.14
18 Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med 2013 1.11
19 Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol 2007 1.07
20 Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones. J Physiol 2005 1.07
21 Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels. J Neurosci 2006 1.01
22 Neuronal homeostasis: time for a change? J Physiol 2011 0.99
23 Fragile X syndrome: from targets to treatments. Neuropharmacology 2012 0.95
24 Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. J Neurosci 2014 0.94
25 PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci 2012 0.87
26 Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression. Channels (Austin) 2009 0.86
27 Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors. J Physiol 2004 0.85
28 Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells. Stem Cells Dev 2014 0.85
29 VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S). Mol Cell Neurosci 2008 0.83
30 Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. J Neurochem 2012 0.83
31 Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits. Biochem Soc Trans 2009 0.80
32 Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit. Eur J Pharmacol 2009 0.79
33 3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors. Chemistry 2012 0.79
34 Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology 2013 0.76
35 The ups and downs of synaptic plasticity: influences on this particular 'market'. J Physiol 2008 0.75
36 Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies. Biochem Soc Trans 2009 0.75