PubRank

Sergio Valente

Author PubWeight™ 42.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell 2010 2.89
2 Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J Am Chem Soc 2010 1.61
3 "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence. Retrovirology 2009 1.59
4 Histone deacetylation in epigenetics: an attractive target for anticancer therapy. Med Res Rev 2005 1.46
5 Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO Rep 2009 1.39
6 Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci 2013 1.25
7 Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling. Circ Res 2007 1.24
8 Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes 2012 1.22
9 Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4). Proc Natl Acad Sci U S A 2012 1.19
10 epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem 2008 1.13
11 Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res 2008 1.07
12 HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2. Biochim Biophys Acta 2008 1.02
13 Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors. Antimicrob Agents Chemother 2004 0.99
14 Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise. Curr Pharm Des 2009 0.99
15 HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol 2010 0.98
16 Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29. PLoS One 2013 0.98
17 Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem 2007 0.97
18 Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol Pharmacol 2007 0.97
19 Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J Med Chem 2009 0.97
20 Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392. Cancer Res 2014 0.96
21 Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia. Stem Cells 2010 0.96
22 Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model. PLoS Curr 2010 0.91
23 A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. J Biol Chem 2013 0.91
24 Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem 2013 0.91
25 Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with histone deacetylase inhibitors. Proteomics 2009 0.89
26 Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem 2011 0.87
27 New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations. Int J Biochem Cell Biol 2008 0.87
28 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem 2004 0.86
29 Emerging approaches for histone deacetylase inhibitor drug discovery. Expert Opin Drug Discov 2015 0.85
30 Sirtuin modulators: an updated patent review (2012 - 2014). Expert Opin Ther Pat 2014 0.84
31 A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Mol Carcinog 2013 0.84
32 Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS. BMC Cancer 2014 0.83
33 Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells. Bioorg Med Chem 2011 0.81
34 Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity. J Mol Cell Biol 2014 0.80
35 Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity. Int J Biochem Cell Biol 2007 0.80
36 3-D QSAR studies on histone deacetylase inhibitors. A GOLPE/GRID approach on different series of compounds. J Chem Inf Model 2006 0.77
37 Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia. J Biol Chem 2013 0.77
38 Chalcone-Coumarin derivatives as potential anti-cancer drugs: an in vitro and in vivo investigation. Anticancer Agents Med Chem 2014 0.77
39 Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg Med Chem Lett 2008 0.76
40 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem 2004 0.76
41 Aurones: interesting natural and synthetic compounds with emerging biological potential. Nat Prod Commun 2012 0.76
42 Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition. ChemMedChem 2006 0.75
43 Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors. J Chromatogr A 2011 0.75