PubRank

Takuji Shirasawa

Author PubWeight™ 82.78‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A 2006 2.40
2 Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 2007 1.90
3 Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. J Biol Chem 2004 1.53
4 Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. J Biol Chem 2003 1.53
5 Antioxidant, EUK-8, prevents murine dilated cardiomyopathy. Circ J 2009 1.52
6 Oxidative stress causes heart failure with impaired mitochondrial respiration. J Biol Chem 2006 1.48
7 Biological significance of isoaspartate and its repair system. Biol Pharm Bull 2005 1.39
8 The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol 2003 1.39
9 Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev 2003 1.31
10 Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis. Am J Pathol 2002 1.30
11 A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol 2003 1.27
12 Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun 2002 1.27
13 Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. J Am Chem Soc 2005 1.23
14 CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem 2006 1.22
15 Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23. Biochem Biophys Res Commun 2002 1.20
16 SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem 2011 1.19
17 Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev 2008 1.18
18 Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol 2009 1.16
19 Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy. Free Radic Biol Med 2010 1.15
20 Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 2010 1.13
21 Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners. Neurosci Lett 2008 1.13
22 Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. J Bone Miner Res 2011 1.12
23 Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J Biol Chem 2005 1.11
24 Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice. Am J Pathol 2008 1.07
25 Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol 2012 1.03
26 Identification of physiological and toxic conformations in Abeta42 aggregates. Chembiochem 2009 1.03
27 Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci 2003 1.02
28 Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals. Neurobiol Dis 2006 1.01
29 Model mice for tissue-specific deletion of the manganese superoxide dismutase gene. Geriatr Gerontol Int 2010 1.00
30 Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Neurochem 2008 1.00
31 Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases. Hum Mol Genet 2007 0.98
32 MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell 2011 0.97
33 Suppression of protein l-isoaspartyl (d-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells. Biochem Biophys Res Commun 2008 0.95
34 Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem 2009 0.95
35 Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem Biophys Res Commun 2012 0.94
36 Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. Biochem Biophys Res Commun 2009 0.94
37 The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice. Invest Ophthalmol Vis Sci 2013 0.94
38 Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. ACS Chem Neurosci 2010 0.92
39 Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathol 2002 0.92
40 Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease. J Alzheimers Dis 2011 0.92
41 EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans. Biochem Biophys Res Commun 2003 0.91
42 Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice. Biol Reprod 2012 0.91
43 Preliminary Clinical Evaluation of Toxicity and Efficacy of A New Astaxanthin-rich Haematococcus pluvialis Extract. J Clin Biochem Nutr 2009 0.90
44 Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr 2012 0.90
45 Presenilin 1 is essential for cardiac morphogenesis. Dev Dyn 2004 0.90
46 Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals. Bioorg Med Chem Lett 2008 0.90
47 Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease. J Neurosci Res 2002 0.90
48 Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its beta-catenin-binding region. Cell Biol Int 2005 0.89
49 Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med 2011 0.89
50 Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure. J Am Coll Cardiol 2008 0.88
51 Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. Biochem Biophys Res Commun 2002 0.88
52 The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease. Geriatr Gerontol Int 2010 0.87
53 Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. J Biosci Bioeng 2005 0.87
54 coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q. Aging Cell 2004 0.87
55 Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice. Molecules 2013 0.87
56 Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos. Mech Ageing Dev 2008 0.86
57 Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res 2002 0.85
58 Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb. Biochem Biophys Res Commun 2002 0.84
59 Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans. Planta Med 2010 0.83
60 Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. Bioorg Med Chem 2005 0.83
61 Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis. J Neurosci Res 2010 0.83
62 The effect of TAT conjugated platinum nanoparticles on lifespan in a nematode Caenorhabditis elegans model. Biomaterials 2010 0.83
63 Standard organ weights among elderly Japanese who died in hospital, including 50 centenarians. Pathol Int 2006 0.83
64 Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Biosci Biotechnol Biochem 2010 0.83
65 Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation. J Neurosci Res 2011 0.83
66 SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice. Metabolism 2012 0.82
67 Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. Biochem Biophys Res Commun 2007 0.81
68 Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice. Biochem Biophys Res Commun 2011 0.81
69 Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency. J Neurosci Res 2002 0.80
70 Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci 2002 0.80
71 Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model. Biosci Biotechnol Biochem 2012 0.80
72 Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice. Biochem Biophys Res Commun 2002 0.79
73 Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochem Res Int 2011 0.79
74 Effect of Ganoderma lucidum extract on adipocyte differentiation and adiponectin gene expression in the murine pre-adipocyte cell line, 3T3-L1. Phytother Res 2011 0.78
75 Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice. Mech Ageing Dev 2009 0.78
76 trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod 2013 0.78
77 Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum. J Physiol Sci 2015 0.78
78 Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42. Biosci Biotechnol Biochem 2008 0.78
79 Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion. J Agric Food Chem 2011 0.78
80 Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous coenzyme Q(10). Exp Gerontol 2012 0.78
81 Loss of parietal cell superoxide dismutase leads to gastric oxidative stress and increased injury susceptibility in mice. Am J Physiol Gastrointest Liver Physiol 2011 0.78
82 Lifespan and glucose metabolism in insulin receptor mutant mice. J Aging Res 2011 0.77
83 Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos. Arch Dermatol Res 2006 0.77
84 Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10. Exp Gerontol 2012 0.77
85 [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. Rinsho Shinkeigaku 2011 0.75
86 [Longevity genes and successful aging]. Nihon Ronen Igakkai Zasshi 2011 0.75
87 [Longevity society and bio-gerontology]. Nihon Ronen Igakkai Zasshi 2012 0.75
88 [Biomedical aging research of Alzheimer's disease]. Nihon Rinsho 2011 0.75
89 [The present and future of antiaging]. Gan To Kagaku Ryoho 2008 0.75
90 Influence of oxidative stress on D-aspartyl endopeptidase activity. Chem Biodivers 2010 0.75
91 Beneficial effect of transfusion with low-affinity red blood cells in endotoxemia. Transfusion 2005 0.75
92 [Caloric restriction and anti-aging]. Nihon Ronen Igakkai Zasshi 2009 0.75
93 [iomarkers for aging]. Nihon Yakurigaku Zasshi 2011 0.75
94 Tissue hyperoxygenation promotes oxidative metabolism in motor unit. J Neurosci Res 2005 0.75
95 Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice. J Neurosci Res 2002 0.75
96 Chemosensory ventilatory responses in the mutant mice with Presbyterian hemoglobinopathy. Respir Physiol Neurobiol 2013 0.75
97 [Aging theory and aging control]. Nihon Ronen Igakkai Zasshi 2010 0.75
98 [Longevity and genes]. Nihon Ronen Igakkai Zasshi 2003 0.75
99 [Anti-aging effects by caloric restriction]. Nihon Rinsho 2009 0.75
100 [Anti-aging research using Mn-SOD conditional knockout mice]. Yakugaku Zasshi 2010 0.75
101 Heme oxygenase-1 (HO-1) is constitutively up-regulated in top alpinists. Biochem Biophys Res Commun 2011 0.75