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1
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Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.
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J Neurosci
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2007
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6.27
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2
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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.
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J Neurosci
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2004
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5.10
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3
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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss.
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Proc Natl Acad Sci U S A
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2003
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4.80
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4
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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.
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J Biol Chem
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2007
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3.35
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5
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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease.
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Proc Natl Acad Sci U S A
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2005
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3.15
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6
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Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.
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Brain Res
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2002
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2.88
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7
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Self-assembly of Abeta(1-42) into globular neurotoxins.
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Biochemistry
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2003
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2.85
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8
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Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.
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J Biol Chem
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2005
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2.56
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9
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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers.
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Proc Natl Acad Sci U S A
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2009
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2.50
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10
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Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.
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Neuron
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2010
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2.34
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11
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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
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J Clin Invest
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2012
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2.33
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12
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Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
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Cell Stem Cell
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2013
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2.32
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13
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Monoclonal antibodies that target pathological assemblies of Abeta.
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J Neurochem
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2006
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2.32
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|
14
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Amyloid beta oligomers induce impairment of neuronal insulin receptors.
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FASEB J
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2007
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2.25
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|
15
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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.
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J Neurosci
|
2010
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2.22
|
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16
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Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor.
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J Am Chem Soc
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2005
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2.21
|
|
17
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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers.
|
Neurobiol Aging
|
2007
|
1.99
|
|
18
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TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
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Cell Metab
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2013
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1.74
|
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19
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Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
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Eur J Neurosci
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2006
|
1.69
|
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20
|
Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.
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J Neurosci
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2006
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1.66
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|
21
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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.
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Neurobiol Learn Mem
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2011
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1.63
|
|
22
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Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
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Brain Res
|
2008
|
1.56
|
|
23
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Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
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Brain Res
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2008
|
1.51
|
|
24
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Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein.
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FASEB J
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2002
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1.48
|
|
25
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Aβ oligomer-induced synapse degeneration in Alzheimer's disease.
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Cell Mol Neurobiol
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2011
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1.33
|
|
26
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Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.
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J Neurosci Res
|
2011
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1.26
|
|
27
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Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}.
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J Biol Chem
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2009
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1.21
|
|
28
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CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.
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PLoS One
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2009
|
1.21
|
|
29
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ADDLs and the signaling web that leads to Alzheimer's disease.
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Neuropharmacology
|
2010
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1.18
|
|
30
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Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening.
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J Mol Neurosci
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2003
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1.12
|
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31
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PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42.
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J Neurochem
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2006
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1.12
|
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32
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Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
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Acta Neuropathol
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2015
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1.11
|
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33
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N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers.
|
J Neurochem
|
2010
|
1.10
|
|
34
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Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity.
|
Neurobiol Aging
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2011
|
1.09
|
|
35
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Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.
|
Toxicol Appl Pharmacol
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2009
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1.08
|
|
36
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FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
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J Clin Invest
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2013
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1.08
|
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37
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The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.
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Am J Pathol
|
2009
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1.07
|
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38
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Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty.
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Neurochem Int
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2007
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1.04
|
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39
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AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.
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Mol Ther
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2009
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0.98
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40
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Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
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PLoS One
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2010
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0.98
|
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41
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Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease.
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Neurobiol Aging
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2011
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0.97
|
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42
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Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.
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J Biol Chem
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2012
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0.96
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43
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Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.
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J Alzheimers Dis
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2009
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0.94
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44
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Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers.
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Aging Cell
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2012
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0.93
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45
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Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
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J Neurosci
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2013
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0.93
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46
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Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers.
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FEBS Lett
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2009
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0.91
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47
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Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model.
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J Alzheimers Dis
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2012
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0.90
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48
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Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers.
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J Med Chem
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2004
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0.90
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49
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Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.
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Life Sci
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2012
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0.89
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50
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Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins.
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CNS Neurol Disord Drug Targets
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2009
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0.88
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51
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Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice.
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J Alzheimers Dis
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2013
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0.87
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52
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Soluble state high resolution atomic force microscopy study of Alzheimer's beta-amyloid oligomers.
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Appl Phys Lett
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2009
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0.86
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53
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Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers.
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Neurobiol Aging
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2008
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0.85
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54
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Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
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J Phys Chem C Nanomater Interfaces
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2009
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0.83
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55
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Nanodisc-solubilized membrane protein library reflects the membrane proteome.
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Anal Bioanal Chem
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2013
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0.83
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56
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Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.
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Acta Neuropathol Commun
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2014
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0.82
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57
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Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies.
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ACS Chem Neurosci
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2012
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0.82
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58
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Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.
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Curr Alzheimer Res
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2007
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0.81
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59
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Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers.
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Acta Neuropathol
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2010
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0.81
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60
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Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.
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FASEB J
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2012
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0.81
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61
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Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.
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ACS Chem Neurosci
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2014
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0.78
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62
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Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers.
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J Mol Neurosci
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2002
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0.78
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63
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Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease.
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Neurobiol Aging
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2013
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0.77
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64
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Aβ oligomers-induced toxicity is attenuated in cells cultured with NbActiv4™ medium.
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Neurotox Res
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2012
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0.77
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65
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Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.
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Chembiochem
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2014
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0.76
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66
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Accumulation of intraneuronal amyloid-β is common in normal brain.
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Curr Alzheimer Res
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2014
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0.76
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67
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A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls.
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Neurodegener Dis
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2016
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0.75
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