PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 1838107)

Published in J Appl Physiol (1985) on December 01, 1991

Authors

S Ono1, N F Voelkel

Author Affiliations

1: Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Articles by these authors

(truncated to the top 100)

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest (2000) 5.26

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med (2001) 3.92

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol (1994) 3.83

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J (2001) 3.20

Autoimmunity and pulmonary hypertension: a perspective. Eur Respir J (2005) 2.82

Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am J Physiol Lung Cell Mol Physiol (2000) 2.73

Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest (1998) 2.54

Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest (1998) 2.37

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J Clin Invest (1995) 2.30

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest (1997) 2.29

Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol (2001) 2.24

Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med (1999) 2.21

Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis. Circ Res (2001) 2.00

Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. J Clin Invest (1987) 1.96

Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ Res (2001) 1.75

Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. Am J Pathol (1999) 1.63

Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis (1990) 1.62

Hypoxia inducible factor-1α in human emphysema lung tissue. Eur Respir J (2010) 1.62

Proactive integrated care improves quality of life in patients with COPD. Eur Respir J (2009) 1.61

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J Clin Invest (1999) 1.59

Nonimmunological production of leukotrienes induced by platelet-activating factor. Science (1982) 1.58

In vitro release of vascular endothelial growth factor during platelet aggregation. Am J Physiol (1998) 1.54

Hypothyroidism and primary pulmonary hypertension: an autoimmune pathogenetic link? Ann Intern Med (1993) 1.51

Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science (1987) 1.47

Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Hum Pathol (1997) 1.46

Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol (1985) (2001) 1.44

Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. J Appl Physiol (1985) (1987) 1.40

HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. Am J Pathol (2001) 1.29

The pathobiology of pulmonary hypertension. Endothelium. Clin Chest Med (2001) 1.27

Pulmonary hypertension and inflammation. J Lab Clin Med (1998) 1.25

The pressure-overloaded right ventricle in pulmonary hypertension. Chest (1998) 1.24

5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Am J Respir Crit Care Med (1998) 1.18

Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling. Am J Respir Crit Care Med (2001) 1.16

Prostaglandins induce vascular endothelial growth factor in a human monocytic cell line and rat lungs via cAMP. Am J Respir Cell Mol Biol (1997) 1.13

Leukotriene C4 and D4 in neonates with hypoxemia and pulmonary hypertension. N Engl J Med (1983) 1.11

PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. J Appl Physiol (1985) (1992) 1.10

Measurement of peptidoleukotrienes in biological fluids. J Appl Physiol (1985) (1990) 1.08

Vasopressin-induced pulmonary vasodilation in rats. Am J Physiol (1989) 1.07

Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. Am J Physiol (1985) 1.06

Analysis of 6-keto PGF1 alpha, 5-HETE, and LTC4 in rat lung: comparison of GM/MS, RIA, and EIA. Prostaglandins (1986) 1.03

Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension. Am J Respir Crit Care Med (1998) 1.00

Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase. Am J Physiol (1995) 1.00

Release of vasodilator prostaglandin, PGI2, from isolated rat lung during vasoconstriction. Circ Res (1981) 0.97

Decreased pulmonary vasoreactivity in an animal model of chronic Pseudomonas pneumonia. Am Rev Respir Dis (1990) 0.93

PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. Prostaglandins (1986) 0.92

Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension. Am J Physiol (1991) 0.92

Hyperuricemia in severe pulmonary hypertension. Chest (2000) 0.92

Effects of hypoxia on density of beta-adrenergic receptors. J Appl Physiol Respir Environ Exerc Physiol (1981) 0.92

Altering hydrodynamic variables influences PGI2 production by isolated lungs and endothelial cells. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.91

Vascular remodeling in neonatal pulmonary hypertension. Role of the smooth muscle cell. Chest (1988) 0.91

Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. Am J Respir Cell Mol Biol (1989) 0.91

Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Eur Respir J (2009) 0.91

Importance of angiotensin-converting enzyme in pulmonary hypertension. Cardiology (1995) 0.91

Endotoxin-induced lung injury in rats: role of eicosanoids. J Appl Physiol (1985) (1989) 0.91

Rapid onset of hypoxic vasoconstriction in isolated lungs. J Appl Physiol (1985) (1992) 0.90

Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8. Eur Respir J (2003) 0.90

Leukotoxin, 9,10-epoxy-12-octadecenoate causes pulmonary vasodilation in rats. Am J Physiol (1995) 0.89

Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness. J Allergy Clin Immunol (1992) 0.89

Effects of shear stress on adhesive interaction between neutrophils and cultured endothelial cells. J Appl Physiol (1985) (1987) 0.88

Ventilatory responses of hamsters and rats to hypoxia and hypercapnia. J Appl Physiol (1985) (1985) 0.88

Pulmonary vascular injury by polycations in perfused rat lungs. J Appl Physiol (1985) (1987) 0.87

Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am J Physiol (1996) 0.87

Plexiform lesion in severe pulmonary hypertension: association with glomeruloid lesion. Am J Pathol (2001) 0.87

Leukotriene synthesis and receptor blockers block hypoxic pulmonary vasoconstriction. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.86

Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. Am Rev Respir Dis (1993) 0.86

Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cell Physiol (1990) 0.86

Increased nitric oxide biosynthesis in leukotoxin,9,10-epoxy-12-octadecenoate injured lung. Biochem Biophys Res Commun (1995) 0.85

"Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells. Arch Biochem Biophys (1995) 0.85

Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. J Appl Physiol Respir Environ Exerc Physiol (1980) 0.85

Lung injury in Fischer but not Sprague-Dawley rats after short-term hyperoxia. Am J Physiol (1990) 0.85

Endothelin-1 potentiates leukotoxin-induced edematous lung injury. J Appl Physiol (1985) (1995) 0.85

Metabolism of platelet-activating factor in isolated perfused rat lung. J Clin Invest (1987) 0.84

Release of von Willebrand factor antigen (vWF:Ag) and eicosanoids during acute injury to the isolated rat lung. Am Rev Respir Dis (1992) 0.84

Diethylcarbamazine inhibits acute and chronic hypoxic pulmonary hypertension in awake rats. Am Rev Respir Dis (1985) 0.84

Actions of lipoxygenase metabolites in isolated rat lungs. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.83

Transforming growth factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP. Pulm Pharmacol Ther (2000) 0.83

Potential role of arachidonic acid metabolites in hypoxic pulmonary vasoconstriction. Chest (1985) 0.83

Proliferation of lung cells in chronically hypoxic rats. An autoradiographic and radiochemical study. Int Arch Occup Environ Health (1981) 0.83

Hydrogen peroxide induced pulmonary vasoconstriction in isolated rat lungs is attenuated by U60,257, a leucotriene synthesis blocker. Wien Klin Wochenschr (1986) 0.83

Right ventricular phenotypic characteristics in subjects with primary pulmonary hypertension or idiopathic dilated cardiomyopathy. J Card Fail (1999) 0.83

Charge-related lung microvascular injury. Am Rev Respir Dis (1989) 0.83

Leukotriene C4 production during hypoxic pulmonary vasoconstriction in isolated rat lungs. Prostaglandins (1984) 0.82

Pulmonary vascular reactivity: effect of PAF and PAF antagonists. J Appl Physiol (1985) (1992) 0.82

Acetylcholine induces vasodilation and prostacyclin synthesis in rat lungs. Prostaglandins (1986) 0.82

Alveolar transfer and metabolism of eicosanoids in the rat. Am Rev Respir Dis (1989) 0.82

Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide. Am Rev Respir Dis (1985) 0.81

Genomic approaches to research in pulmonary hypertension. Respir Res (2001) 0.81

Role of membrane lipids in the control of normal vascular tone. Am Rev Respir Dis (1987) 0.81

Role of peptidoleukotrieens in hypoxic pulmonary vasoconstriction in rats. Am J Physiol (1990) 0.81

Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. Am J Physiol (1990) 0.81

Leukotoxins and the lung. Pulm Pharmacol Ther (1999) 0.81

Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension. J Appl Physiol (1985) (1989) 0.80

Species variations in the pulmonary responses to arachidonic acid metabolites. Prostaglandins (1985) 0.80

Elevated urinary leukotriene E4 excretion in patients with ARDS and severe burns. Prostaglandins Leukot Essent Fatty Acids (1991) 0.80

Urine leukotriene E4 levels are elevated in patients with active systemic lupus erythematosus. J Rheumatol (1992) 0.80

Role of eicosanoids in staphylococcal alpha-toxin-induced lung injury in the rat. Am J Physiol (1992) 0.79

Pulmonary vascular reactivity in Fischer rats. J Appl Physiol (1985) (1991) 0.79

Chronic propranolol treatment decreases pulmonary artery pressure in conscious dogs. Clin Physiol Biochem (1984) 0.79

Urinary leukotriene E4 levels in high-altitude pulmonary edema. A possible role for inflammation. Chest (1996) 0.79

Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.79