Published in Am J Pathol on April 10, 2008
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. J Clin Aesthet Dermatol (2010) 0.96
Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Photochem Photobiol (2010) 0.87
Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage. J Dermatol Sci (2009) 0.85
Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin. Toxicol Appl Pharmacol (2014) 0.84
Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas. J Invest Dermatol (2012) 0.81
A bio-mimetic approach to DNA photoprotection. J Invest Dermatol (2013) 0.79
Novel investigational drugs for basal cell carcinoma. Expert Opin Investig Drugs (2010) 0.78
Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier. Int J Nanomedicine (2011) 0.75
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A (1991) 6.42
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 5.89
The epidemiology of UV induced skin cancer. J Photochem Photobiol B (2001) 5.05
Nevoid basal-cell carcinoma syndrome. Medicine (Baltimore) (1987) 4.60
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28
Mechanisms of DNA excision repair. Science (1994) 2.69
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med (1999) 2.39
DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc Natl Acad Sci U S A (1993) 2.27
Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst (1996) 2.26
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis (1999) 2.08
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol (2005) 1.90
Inhibition of cyclooxygenase-2 gene expression by p53. J Biol Chem (1999) 1.62
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res (2004) 1.50
DNA damage enhances melanogenesis. Proc Natl Acad Sci U S A (1996) 1.48
Evidence that exposure of the telomere 3' overhang sequence induces senescence. Proc Natl Acad Sci U S A (2003) 1.37
Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proc Natl Acad Sci U S A (1996) 1.36
Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci U S A (1997) 1.33
Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss. Cancer Res (1994) 1.29
Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem Photobiol (2002) 1.28
DNA damage and melanogenesis. Nature (1994) 1.25
Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res (2004) 1.24
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J (2007) 1.22
Telomere-based DNA damage responses: a new approach to melanoma. FASEB J (2004) 1.21
UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.21
8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res (2005) 1.15
8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol (1996) 1.13
Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. Biochem Biophys Res Commun (2001) 1.11
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res (2007) 1.06
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci U S A (2004) 1.04
Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation. Cancer Res (2004) 1.01
Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. J Invest Dermatol (2006) 0.96
Novel Hedgehog pathway targets against basal cell carcinoma. Toxicol Appl Pharmacol (2006) 0.96
T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. J Biol Chem (2005) 0.96
Features that determine telomere homolog oligonucleotide-induced therapeutic DNA damage-like responses in cancer cells. J Cell Physiol (2007) 0.93
Long-term health risk to the skin of ultraviolet radiation. Prog Biophys Mol Biol (2006) 0.93
DNA oligonucleotide treatment corrects the age-associated decline in DNA repair capacity. FASEB J (2002) 0.92
T-oligos augment UV-induced protective responses in human skin. FASEB J (2006) 0.86
Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cells. J Invest Dermatol (2000) 0.86
Thymidine dinucleotide mimics the effect of solar simulated irradiation on p53 and p53-regulated proteins. J Invest Dermatol (1999) 0.84
The tale of the telomere: implications for prevention and treatment of skin cancers. J Investig Dermatol Symp Proc (2005) 0.84
Immunophenotypic analysis of the p53 gene in non-melanoma skin cancer and correlation with apoptosis and cell proliferation. J Eur Acad Dermatol Venereol (2005) 0.82
Molecular and cellular biology of basal cell carcinoma. Australas J Dermatol (2002) 0.81
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. J Am Acad Dermatol (2001) 0.80
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med (2012) 4.19
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med (2009) 2.99
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
A call for the development and implementation of a targeted national melanoma screening program. Arch Dermatol (2006) 2.29
Academic dermatology manpower: issues of recruitment and retention. Arch Dermatol (2007) 2.02
Dermoscopic changes in melanocytic naevi in children during digital follow-up. Acta Derm Venereol (2012) 1.99
Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice. Cancer Prev Res (Phila) (2010) 1.91
Melanoma incidence and mortality among US whites, 1969-1999. JAMA (2002) 1.74
Sunlight, tanning booths, and vitamin D. J Am Acad Dermatol (2005) 1.68
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A (2006) 1.66
The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol (2006) 1.66
Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56
Ultraviolet-fluorescent tattoo location of cutaneous biopsy site. Dermatol Surg (2011) 1.51
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res (2004) 1.50
Visual screening for malignant melanoma: a cost-effectiveness analysis. Arch Dermatol (2007) 1.41
Pitfalls of evidence-based medicine: the example of actinic keratosis therapy. Arch Dermatol (2012) 1.40
Evidence that exposure of the telomere 3' overhang sequence induces senescence. Proc Natl Acad Sci U S A (2003) 1.37
Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem Photobiol (2002) 1.28
Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J (2003) 1.27
Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles. J Invest Dermatol (2002) 1.25
Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem (2001) 1.23
Skin cancer prevention and detection practices among siblings of patients with melanoma. J Am Acad Dermatol (2003) 1.22
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J (2007) 1.22
Telomere-based DNA damage responses: a new approach to melanoma. FASEB J (2004) 1.21
Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors. Exp Dermatol (2006) 1.16
p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol (2003) 1.16
A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol (2004) 1.14
Improving skin cancer prevention and detection education in US medical schools. Arch Dermatol (2006) 1.14
Induction of apoptosis by telomere 3' overhang-specific DNA. Exp Cell Res (2002) 1.14
Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila) (2011) 1.12
Unity in action. J Invest Dermatol (2014) 1.12
MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes. Biochem J (2006) 1.11
Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proc Natl Acad Sci U S A (2004) 1.10
Fifty years of skin aging. J Investig Dermatol Symp Proc (2002) 1.10
Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential. Int J Cancer (2009) 1.08
Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice. Am J Pathol (2009) 1.07
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res (2007) 1.06
A randomized trial to improve early detection and prevention practices among siblings of melanoma patients. Cancer (2006) 1.05
Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides. Exp Cell Res (2004) 1.05
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci U S A (2004) 1.04
Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA. FASEB J (2003) 1.04
A role for WRN in telomere-based DNA damage responses. Proc Natl Acad Sci U S A (2006) 1.03
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest (2004) 1.03
Nanoelectroablation therapy for murine basal cell carcinoma. Biochem Biophys Res Commun (2012) 1.03
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res (2011) 1.02
Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation. Cancer Res (2004) 1.01
The first 15 years of the American Academy of Dermatology skin cancer screening programs: 1985-1999. J Am Acad Dermatol (2003) 1.00
delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome. Dermatol Surg (2004) 0.97
Fate of melanocytes during development of the hair follicle pigmentary unit. J Investig Dermatol Symp Proc (2003) 0.97
Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis. Mol Cancer Ther (2008) 0.96
Novel Hedgehog pathway targets against basal cell carcinoma. Toxicol Appl Pharmacol (2006) 0.96
T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. J Biol Chem (2005) 0.96
Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice. Carcinogenesis (2009) 0.96
Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. Cancer Causes Control (2010) 0.95
Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med (2004) 0.95
Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. Adv Exp Med Biol (2011) 0.94
Features that determine telomere homolog oligonucleotide-induced therapeutic DNA damage-like responses in cancer cells. J Cell Physiol (2007) 0.93
Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation. J Invest Dermatol (2004) 0.92
Successful treatment of a 9-year-old boy affected by acrodermatitis continua of Hallopeau with targeted ultraviolet B narrow-band phototherapy. Photodermatol Photoimmunol Photomed (2010) 0.92
DNA oligonucleotide treatment corrects the age-associated decline in DNA repair capacity. FASEB J (2002) 0.92
Primary cutaneous mantle cell lymphoma. Acta Derm Venereol (2011) 0.91
Psychosocial aspects of aging skin. Dermatol Clin (2005) 0.91
The year of unity. J Invest Dermatol (2013) 0.90
First-in-human trial of nanoelectroablation therapy for basal cell carcinoma: proof of method. Exp Dermatol (2014) 0.89
Quantification of inducible SOS-like photoprotective responses in human skin. J Invest Dermatol (2007) 0.89
Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. J Invest Dermatol (2011) 0.88
Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Res (2003) 0.87
T-oligos augment UV-induced protective responses in human skin. FASEB J (2006) 0.86
The interdependence of skin aging, skin cancer, and DNA repair capacity: a novel perspective with therapeutic implications. Rejuvenation Res (2004) 0.85
Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage. J Dermatol Sci (2009) 0.85
Tyrosinase gene expression is regulated by p53. J Invest Dermatol (2002) 0.85
Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res (2004) 0.85
The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes. J Cell Sci (2004) 0.84
Modulation of vascular endothelial growth factor receptors in melanocytes. Exp Dermatol (2005) 0.84
High prevalence of vitamin D deficiency in patients with basal cell nevus syndrome. Arch Dermatol (2010) 0.84
Modulations of nerve growth factor and Bcl-2 in ultraviolet-irradiated human epidermis. J Cutan Pathol (2003) 0.84
Mutations in ATP2A2 in patients with Darier's disease. J Invest Dermatol (2003) 0.83
Should the skin cancer examination be taught in medical school? Arch Dermatol (2002) 0.83
Bone morphogenetic protein-4, a novel modulator of melanogenesis. J Biol Chem (2006) 0.83
Bullous scabies simulating pemphigoid. J Cutan Med Surg (2011) 0.83
Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss. J Invest Dermatol (2003) 0.83
Broad area photodynamic therapy for treatment of multiple basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome. J Drugs Dermatol (2006) 0.82
Statin use and risk of basal cell carcinoma. J Am Acad Dermatol (2009) 0.82
Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) with absence of desmoglein 1 and 3 antibodies: case report and literature review. Am J Clin Dermatol (2008) 0.82
More on MITF. J Invest Dermatol (2002) 0.82
UV induces VEGF through a TNF-alpha independent pathway. FASEB J (2003) 0.82
Large plaque type blue nevus with subcutaneous cellular nodules. Eur J Dermatol (2009) 0.81