Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy.

Bacterial antisense RNAs: how many are there, and what are they doing? Annu Rev Genet (2010) 2.47

Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages. World J Exp Med (2015) 0.75

Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature (2006) 5.81

Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species. J Clin Microbiol (2004) 4.70

A clinical classification of the acute respiratory distress syndrome for predicting outcome and guiding medical therapy*. Crit Care Med (2015) 2.78

Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care (2008) 2.65

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A (2007) 2.43

Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome. Antimicrob Agents Chemother (2005) 2.08

Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy. J Am Chem Soc (2006) 1.87

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus. Chem Biol (2011) 1.80

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem (2003) 1.75

Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity. Angew Chem Int Ed Engl (2007) 1.52

Discovery of FabH/FabF inhibitors from natural products. Antimicrob Agents Chemother (2006) 1.51

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci U S A (2011) 1.43

Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture. Antimicrob Agents Chemother (2006) 1.35

Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol (2010) 1.34

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus. Chem Biol (2009) 1.23

Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase. Org Lett (2002) 1.23

Confronting the challenges of natural product-based antifungal discovery. Chem Biol (2011) 1.19

Determination of selectivity and efficacy of fatty acid synthesis inhibitors. J Biol Chem (2004) 1.17

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products. Chem Biol (2008) 1.15

High-throughput culturing of fungi from plant litter by a dilution-to-extinction technique. FEMS Microbiol Ecol (2007) 1.15

Biosynthetic studies of platensimycin. J Am Chem Soc (2007) 1.08

Structure and semisynthesis of platensimide A, produced by Streptomyces platensis. Org Lett (2008) 1.07

Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships. J Nat Prod (2004) 1.06

Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris. Mar Drugs (2013) 1.06

Antimicrobial activity of heterotrophic bacterial communities from the marine sponge Erylus discophorus (Astrophorida, Geodiidae). PLoS One (2013) 1.02

Novel illudins from Coprinopsis episcopalis (syn. Coprinus episcopalis), and the distribution of illudin-like compounds among filamentous fungi. Mycol Res (2003) 1.02

A general analytical strategy for the characterization of phenolic compounds in fruit juices by high-performance liquid chromatography with diode array detection coupled to electrospray ionization and triple quadrupole mass spectrometry. J Chromatogr A (2009) 0.99

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin. J Biomol Screen (2012) 0.98

Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. Fungal Genet Biol (2010) 0.98

Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum. J Nat Prod (2009) 0.97

Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. J Nat Prod (2009) 0.96

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi. Mycologia (2009) 0.96

Platensimycin and platencin congeners from Streptomyces platensis. J Nat Prod (2011) 0.94

Chemometric characterization of fruit juices from Spanish cultivars according to their phenolic compound contents: I. Citrus fruits. J Agric Food Chem (2012) 0.93

Synthesis and biological evaluation of platensimycin analogs. Bioorg Med Chem Lett (2009) 0.93

Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod (2004) 0.93

Basic microbiological techniques used in antibacterial drug discovery. Curr Protoc Pharmacol (2006) 0.93

Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett (2011) 0.92

Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test. J Nat Prod (2011) 0.92

New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. Rapid Commun Mass Spectrom (2008) 0.92

Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity. J Nat Prod (2007) 0.91

Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis. Bioorg Med Chem (2010) 0.91

The rheumatoid arthritis-associated allele HLA-DR10 (DRB1*1001) shares part of its repertoire with HLA-DR1 (DRB1*0101) and HLA-DR4 (DRB*0401). Arthritis Rheum (2008) 0.91

Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer. Cancer (2006) 0.91

Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc (2008) 0.91

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy. J Nat Prod (2006) 0.90

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study. Nat Prod Rep (2014) 0.90

Biosynthesis of nodulisporic acid A: precursor studies. J Am Chem Soc (2002) 0.90

On-line characterisation of apple polyphenols by liquid chromatography coupled with mass spectrometry and ultraviolet absorbance detection. J Chromatogr A (2004) 0.90

Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J Ind Microbiol Biotechnol (2004) 0.90

Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test. J Nat Prod (2009) 0.89

Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis. Chem Commun (Camb) (2008) 0.89

Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products. Bioorg Med Chem Lett (2008) 0.89

Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation. Chem Biodivers (2005) 0.89