| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
|
J Am Soc Nephrol
|
2002
|
1.85
|
|
2
|
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.
|
Int J Clin Oncol
|
2009
|
1.82
|
|
3
|
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
|
J Am Soc Nephrol
|
2006
|
1.80
|
|
4
|
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway.
|
J Biol Chem
|
2002
|
1.79
|
|
5
|
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
|
J Am Soc Nephrol
|
2009
|
1.70
|
|
6
|
Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.
|
Mol Pharmacol
|
2009
|
1.53
|
|
7
|
Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.
|
Pharm Res
|
2004
|
1.49
|
|
8
|
Tacrolimus therapy as an alternative to thiopurines for maintaining remission in patients with refractory ulcerative colitis.
|
J Clin Gastroenterol
|
2011
|
1.47
|
|
9
|
Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation.
|
Liver Transpl
|
2003
|
1.46
|
|
10
|
Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.
|
Am J Physiol Cell Physiol
|
2008
|
1.38
|
|
11
|
Is MIBG a substrate of P-glycoprotein?
|
Eur J Nucl Med Mol Imaging
|
2006
|
1.37
|
|
12
|
Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer.
|
J Thorac Oncol
|
2010
|
1.34
|
|
13
|
Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B.
|
Hum Mutat
|
2011
|
1.31
|
|
14
|
Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat.
|
Biochem Pharmacol
|
2005
|
1.28
|
|
15
|
A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study.
|
Circ J
|
2007
|
1.26
|
|
16
|
An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients.
|
Pharmacol Ther
|
2006
|
1.22
|
|
17
|
Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients.
|
Clin Pharmacol Ther
|
2006
|
1.20
|
|
18
|
Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.
|
J Pharmacol Exp Ther
|
2009
|
1.18
|
|
19
|
Metformin transport by renal basolateral organic cation transporter hOCT2.
|
Pharm Res
|
2005
|
1.16
|
|
20
|
Peptide transporters: structure, function, regulation and application for drug delivery.
|
Curr Drug Metab
|
2004
|
1.14
|
|
21
|
INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.
|
Blood
|
2006
|
1.12
|
|
22
|
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics.
|
Br J Pharmacol
|
2011
|
1.11
|
|
23
|
Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients.
|
Pharmacogenet Genomics
|
2008
|
1.08
|
|
24
|
Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A).
|
Biochem Pharmacol
|
2007
|
1.07
|
|
25
|
Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer.
|
Drug Metab Dispos
|
2008
|
1.06
|
|
26
|
Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1.
|
Pharm Res
|
2006
|
1.01
|
|
27
|
The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1.
|
Biochem Pharmacol
|
2006
|
1.00
|
|
28
|
Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1.
|
Am J Physiol Renal Physiol
|
2006
|
0.99
|
|
29
|
Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.
|
Drug Metab Pharmacokinet
|
2005
|
0.99
|
|
30
|
Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney.
|
J Biol Chem
|
2003
|
0.98
|
|
31
|
Gene expression and regulation of drug transporters in the intestine and kidney.
|
Biochem Pharmacol
|
2006
|
0.96
|
|
32
|
Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.
|
AAPS J
|
2013
|
0.95
|
|
33
|
Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial.
|
BMC Med
|
2010
|
0.95
|
|
34
|
Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients.
|
Pharmacogenet Genomics
|
2006
|
0.94
|
|
35
|
CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.
|
Pharmacogenetics
|
2004
|
0.94
|
|
36
|
Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.
|
Am J Physiol Renal Physiol
|
2008
|
0.94
|
|
37
|
Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1.
|
Org Lett
|
2006
|
0.92
|
|
38
|
Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients.
|
Drug Metab Dispos
|
2009
|
0.92
|
|
39
|
Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.
|
Am J Physiol Renal Physiol
|
2008
|
0.92
|
|
40
|
Pharmacodynamic analysis of tacrolimus and cyclosporine in living-donor liver transplant patients.
|
Clin Pharmacol Ther
|
2005
|
0.92
|
|
41
|
Multidrug and toxin extrusion family SLC47: physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K.
|
Mol Aspects Med
|
2013
|
0.91
|
|
42
|
Novel riboflavin transporter family RFVT/SLC52: identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52.
|
Mol Aspects Med
|
2013
|
0.91
|
|
43
|
Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.
|
Am J Physiol Renal Physiol
|
2007
|
0.91
|
|
44
|
Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters.
|
Drug Metab Pharmacokinet
|
2010
|
0.91
|
|
45
|
Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.
|
J Hum Genet
|
2009
|
0.90
|
|
46
|
Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2.
|
Biochem Pharmacol
|
2009
|
0.90
|
|
47
|
Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury.
|
Eur J Pharmacol
|
2012
|
0.89
|
|
48
|
Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3.
|
Pharm Res
|
2006
|
0.89
|
|
49
|
Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury.
|
Drug Metab Dispos
|
2008
|
0.89
|
|
50
|
Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.
|
J Pharmacol Exp Ther
|
2003
|
0.88
|
|
51
|
Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus.
|
J Surg Res
|
2002
|
0.88
|
|
52
|
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
|
Kidney Int
|
2002
|
0.87
|
|
53
|
Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function.
|
Biochem Biophys Res Commun
|
2004
|
0.87
|
|
54
|
Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.
|
Drug Metab Pharmacokinet
|
2006
|
0.87
|
|
55
|
Human NPC1L1 expression is positively regulated by PPARα.
|
Pharm Res
|
2010
|
0.87
|
|
56
|
Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
|
Am J Physiol Gastrointest Liver Physiol
|
2006
|
0.87
|
|
57
|
Hepatocyte nuclear factor-4{alpha} regulates the human organic anion transporter 1 gene in the kidney.
|
Am J Physiol Renal Physiol
|
2007
|
0.86
|
|
58
|
Recent advances in structural biology of peptide transporters.
|
Curr Top Membr
|
2012
|
0.86
|
|
59
|
Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2.
|
Biochem Pharmacol
|
2009
|
0.85
|
|
60
|
Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE).
|
Mol Pharmacol
|
2007
|
0.84
|
|
61
|
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.
|
Biochem Pharmacol
|
2005
|
0.84
|
|
62
|
Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient.
|
Drug Metab Pharmacokinet
|
2006
|
0.84
|
|
63
|
Decreased expression of glucose and peptide transporters in rat remnant kidney.
|
Drug Metab Pharmacokinet
|
2004
|
0.84
|
|
64
|
Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.
|
Pharm Res
|
2013
|
0.84
|
|
65
|
Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
|
Drug Metab Pharmacokinet
|
2004
|
0.83
|
|
66
|
Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.
|
Am J Physiol Renal Physiol
|
2010
|
0.83
|
|
67
|
Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives.
|
J Pharmacol Exp Ther
|
2006
|
0.83
|
|
68
|
Prospective evaluation of the bayesian method for individualizing tacrolimus dose early after living-donor liver transplantation.
|
J Clin Pharmacol
|
2009
|
0.82
|
|
69
|
Thyroid hormone regulates the expression and function of P-glycoprotein in Caco-2 cells.
|
Pharm Res
|
2007
|
0.82
|
|
70
|
Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.
|
Pharm Res
|
2003
|
0.82
|
|
71
|
Forecasting of blood tacrolimus concentrations based on the Bayesian method in adult patients receiving living-donor liver transplantation.
|
Clin Pharmacokinet
|
2003
|
0.82
|
|
72
|
Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study.
|
Int J Clin Oncol
|
2010
|
0.82
|
|
73
|
Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.
|
Biochem Pharmacol
|
2003
|
0.82
|
|
74
|
Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract.
|
Biochem Pharmacol
|
2005
|
0.82
|
|
75
|
Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo.
|
J Pharmacol Exp Ther
|
2002
|
0.81
|
|
76
|
Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases.
|
Pharm Res
|
2004
|
0.81
|
|
77
|
Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1).
|
Am J Physiol Gastrointest Liver Physiol
|
2008
|
0.80
|
|
78
|
Computational modelling of H+-coupled peptide transport via human PEPT1.
|
J Physiol
|
2005
|
0.80
|
|
79
|
Efficacy and safety of infliximab as rescue therapy for ulcerative colitis refractory to tacrolimus.
|
J Gastroenterol Hepatol
|
2010
|
0.80
|
|
80
|
A case of radiation recall pneumonitis induced by erlotinib, which can be related to high plasma concentration.
|
J Thorac Oncol
|
2010
|
0.80
|
|
81
|
Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients.
|
J Hum Genet
|
2003
|
0.79
|
|
82
|
Absence of influence of concomitant administration of rabeprazole on the pharmacokinetics of tacrolimus in adult living-donor liver transplant patients: a case-control study.
|
Drug Metab Pharmacokinet
|
2009
|
0.79
|
|
83
|
A retrospective analysis of vancomycin pharmacokinetics in Japanese cancer and non-cancer patients based on routine trough monitoring data.
|
Biol Pharm Bull
|
2009
|
0.79
|
|
84
|
Na(+)-dependent fructose transport via rNaGLT1 in rat kidney.
|
FEBS Lett
|
2003
|
0.79
|
|
85
|
Distinct effects of omeprazole and rabeprazole on the tacrolimus blood concentration in a kidney transplant recipient.
|
Drug Metab Pharmacokinet
|
2007
|
0.79
|
|
86
|
Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5.
|
Drug Metab Pharmacokinet
|
2008
|
0.79
|
|
87
|
Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation.
|
Drug Metab Pharmacokinet
|
2006
|
0.78
|
|
88
|
Renal tubular secretion of varenicline by multidrug and toxin extrusion (MATE) transporters.
|
Drug Metab Pharmacokinet
|
2012
|
0.78
|
|
89
|
Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats.
|
Pharm Res
|
2004
|
0.78
|
|
90
|
Time-saving multiplex detection of single nucleotide polymorphisms by ultrasensitive DNA microarray.
|
J Biochem
|
2010
|
0.78
|
|
91
|
Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2.
|
Biochem Pharmacol
|
2003
|
0.78
|
|
92
|
Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats.
|
Drug Metab Pharmacokinet
|
2002
|
0.77
|
|
93
|
[Role of UGT1A1*28 and UGT1A1*6 for irinotecan-induced adverse drug reaction].
|
Gan To Kagaku Ryoho
|
2008
|
0.77
|
|
94
|
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis.
|
Pharm Res
|
2005
|
0.77
|
|
95
|
Tacrolimus therapy according to mucosal MDR1 levels in small-bowel transplant recipients.
|
Clin Pharmacol Ther
|
2004
|
0.77
|
|
96
|
Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein.
|
Am J Physiol Renal Physiol
|
2012
|
0.77
|
|
97
|
Population analysis of myelosuppression profiles using routine clinical data after the ICE (ifosfamide/carboplatin/etoposide) regimen for malignant gliomas.
|
J Pharm Sci
|
2009
|
0.77
|
|
98
|
Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo.
|
Pharm Res
|
2004
|
0.77
|
|
99
|
Effects of metabolic acidosis on expression levels of renal drug transporters.
|
Pharm Res
|
2010
|
0.76
|
|
100
|
Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3.
|
Biochem Pharmacol
|
2007
|
0.76
|
|
101
|
Simulation for population pharmacodynamic analysis of dose-ranging trials: usefulness of the mixture model analysis for detecting nonresponders.
|
Pharm Res
|
2002
|
0.76
|
|
102
|
Characterization of the Basal promoter element of human organic cation transporter 2 gene.
|
J Pharmacol Exp Ther
|
2007
|
0.76
|
|
103
|
Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney.
|
Biochem Pharmacol
|
2005
|
0.76
|
|
104
|
Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction.
|
J Pharm Pharmacol
|
2002
|
0.76
|
|
105
|
Evaluation of the potency of telaprevir and its metabolites as inhibitors of renal organic cation transporters, a potential mechanism for the elevation of serum creatinine.
|
Drug Metab Pharmacokinet
|
2013
|
0.75
|
|
106
|
[Effect of probucol on the blood concentration of cyclosporin A in patients with nephrotic syndrome: a case study with a microemulsion formulation (Neoral)].
|
Nihon Jinzo Gakkai Shi
|
2002
|
0.75
|
|
107
|
Required transient dose escalation of tacrolimus in living-donor liver transplant recipients with high concentrations of a minor metabolite M-II in bile.
|
Drug Metab Pharmacokinet
|
2008
|
0.75
|
|
108
|
Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats.
|
Pharm Res
|
2002
|
0.75
|
|
109
|
Evaluation of Calvert's formula for dosage adjustment of carboplatin in Japanese patients with hormone refractory prostate cancer.
|
Biol Pharm Bull
|
2006
|
0.75
|
|
110
|
[The pharmacogenomics of drug transporters: functional analysis approaches].
|
Tanpakushitsu Kakusan Koso
|
2004
|
0.75
|
|
111
|
Altered pharmacokinetics of paclitaxel in experimental hepatic or renal failure.
|
Pharm Res
|
2005
|
0.75
|
|
112
|
A transient increase of calcineurin phosphatase activity in living-donor kidney transplant recipients with acute rejection.
|
Drug Metab Pharmacokinet
|
2010
|
0.75
|
|
113
|
The globalization of JSSX and DMPK and progress in research.
|
Drug Metab Pharmacokinet
|
2010
|
0.75
|
|
114
|
Effect of itraconazole on the pharmacokinetics of everolimus administered by different routes in rats.
|
Biopharm Drug Dispos
|
2009
|
0.75
|
|
115
|
p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line.
|
Pharm Res
|
2002
|
0.75
|
|
116
|
Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes.
|
Biochim Biophys Acta
|
2003
|
0.75
|
|
117
|
Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3.
|
Am J Physiol Renal Physiol
|
2007
|
0.75
|
|
118
|
[Clinical usefulness of serum total cholesterol as an index of hypothyroidism in patients after cervical radiation].
|
Yakugaku Zasshi
|
2003
|
0.75
|
|
119
|
Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum.
|
Biochem Pharmacol
|
2004
|
0.75
|