PubRank

Roberto Cappai

Author PubWeight™ 123.03‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 2005 4.34
2 Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 2012 3.31
3 Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 2010 2.46
4 Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 2008 2.30
5 Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem 2002 1.99
6 Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. J Neurosci 2008 1.86
7 Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. J Neurosci 2005 1.83
8 The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim Biophys Acta 2007 1.83
9 Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. J Biol Chem 2002 1.74
10 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain 2011 1.67
11 Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 2006 1.63
12 In vitro characterization of Pittsburgh compound-B binding to Lewy bodies. J Neurosci 2007 1.52
13 The role of exosomes in the processing of proteins associated with neurodegenerative diseases. Eur Biophys J 2007 1.50
14 Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem 2003 1.38
15 Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid. Vet Immunol Immunopathol 2008 1.36
16 Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity. J Mol Biol 2004 1.32
17 Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A 2009 1.29
18 Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB J 2004 1.29
19 Plasma alpha-synuclein is decreased in subjects with Parkinson's disease. Exp Neurol 2006 1.23
20 ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. J Neurochem 2008 1.20
21 Metals and amyloid-beta in Alzheimer's disease. Int J Exp Pathol 2005 1.19
22 Characterization of PiB binding to white matter in Alzheimer disease and other dementias. J Nucl Med 2009 1.19
23 Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein. Biochemistry 2008 1.18
24 Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol 2008 1.17
25 Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics. J Neurochem 2006 1.16
26 Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation. J Biol Chem 2003 1.14
27 Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. J Biol Chem 2005 1.14
28 Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions. J Mol Biol 2005 1.12
29 Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem 2006 1.10
30 Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation. Free Radic Biol Med 2009 1.09
31 The structure of dopamine induced alpha-synuclein oligomers. Eur Biophys J 2010 1.08
32 Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol 2006 1.07
33 Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture. Int J Biochem Cell Biol 2008 1.06
34 Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide. Biochemistry 2007 1.06
35 The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein. J Biol Chem 2009 1.05
36 Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution. J Biol Chem 2004 1.04
37 Correlative studies support lipid peroxidation is linked to PrP(res) propagation as an early primary pathogenic event in prion disease. Brain Res Bull 2005 1.03
38 A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model. Neurotox Res 2009 1.03
39 Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology. J Inorg Biochem 2006 1.02
40 Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One 2011 1.02
41 Modulation of alpha-synuclein aggregation by dopamine: a review. Neurochem Res 2009 1.02
42 6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation. J Biol Chem 2006 1.01
43 Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease. J Biol Chem 2004 1.00
44 Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species. FEBS J 2007 0.99
45 Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers. Protein Eng Des Sel 2008 0.99
46 Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem 2004 0.99
47 Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence. Biochem Biophys Res Commun 2009 0.99
48 The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias. Mol Neurobiol 2008 0.99
49 Delineating common molecular mechanisms in Alzheimer's and prion diseases. Trends Biochem Sci 2006 0.98
50 Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys J 2007 0.98
51 Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy. J Am Chem Soc 2008 0.97
52 A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease. Proteomics 2010 0.96
53 Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner. J Mol Biol 2009 0.96
54 The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease. J Exp Med 2012 0.96
55 Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease. FEBS Lett 2010 0.94
56 Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci 2002 0.94
57 Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease. Proc Natl Acad Sci U S A 2008 0.93
58 Neurotoxicity from glutathione depletion is dependent on extracellular trace copper. J Neurosci Res 2003 0.93
59 Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol 2006 0.93
60 Dimeric structures of alpha-synuclein bind preferentially to lipid membranes. Biochim Biophys Acta 2008 0.92
61 Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Aging 2005 0.89
62 Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.88
63 The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. Brain Res 2011 0.88
64 Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease. J Virol 2010 0.88
65 Copper binding to the Alzheimer's disease amyloid precursor protein. Eur Biophys J 2007 0.88
66 Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity. Neurobiol Aging 2009 0.87
67 Amyloid-β: the seeds of darkness. Int J Biochem Cell Biol 2011 0.87
68 sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury. J Neurochem 2012 0.86
69 Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. PLoS One 2012 0.86
70 An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatr Dis Treat 2008 0.85
71 Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons. J Neurosci 2010 0.85
72 Alois Alzheimer and Alzheimer's disease: a centennial perspective. J Neurochem 2006 0.85
73 Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. J Biol Chem 2011 0.85
74 Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease. Free Radic Biol Med 2002 0.84
75 Iron inhibits neurotoxicity induced by trace copper and biological reductants. J Biol Inorg Chem 2004 0.84
76 Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. J Alzheimers Dis 2010 0.84
77 Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study. Mol Biosyst 2014 0.84
78 Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease. Mol Biosyst 2008 0.83
79 Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity. J Biol Chem 2010 0.83
80 In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies. Eur J Pharmacol 2009 0.83
81 Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices. Brain Res 2009 0.83
82 α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease. J Neurochem 2014 0.82
83 Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments. FASEB J 2012 0.82
84 In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer. Nucl Med Biol 2012 0.82
85 Evidence for a copper-binding superfamily of the amyloid precursor protein. Biochemistry 2002 0.82
86 Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.81
87 Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF). Brain Res 2002 0.81
88 Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP. Immunol Cell Biol 2005 0.81
89 Cu2+-induced modification of the kinetics of A beta(1-42) channels. Am J Physiol Cell Physiol 2003 0.81
90 Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Brain Res Mol Brain Res 2004 0.81
91 SERF protein is a direct modifier of amyloid fiber assembly. Cell Rep 2012 0.81
92 Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation. Brain Res 2003 0.80
93 Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine. Auton Neurosci 2008 0.80
94 Evaluation of the effects of treatment with sAPPα on functional and histological outcome following controlled cortical impact injury in mice. Neurosci Lett 2012 0.80
95 Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate. J Biol Chem 2014 0.79
96 Gene knockout of tau expression does not contribute to the pathogenesis of prion disease. J Neuropathol Exp Neurol 2011 0.79
97 The neurotransmitter serotonin interrupts α-synuclein amyloid maturation. Biochim Biophys Acta 2011 0.79
98 Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury. Brain Res 2012 0.79
99 APP involvement in retinogenesis of mice. Acta Neuropathol 2010 0.79
100 The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding. Biosci Rep 2013 0.79
101 Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice. Cell Mol Neurobiol 2009 0.79
102 The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism. J Biol Chem 2012 0.78
103 Amyloid imaging in Alzheimer's disease and other dementias. Brain Imaging Behav 2009 0.78
104 A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques. Chem Commun (Camb) 2010 0.78
105 The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110. J Neurochem 2013 0.78
106 Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis. Metallomics 2014 0.78
107 Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport 2002 0.78
108 Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue. Metallomics 2014 0.77
109 PAMAM dendrimers as potential agents against fibrillation of alpha-synuclein, a Parkinson's disease-related protein. Macromol Biosci 2009 0.77
110 Neurotoxicity of prion peptides on cultured cerebellar neurons. Methods Mol Biol 2008 0.77
111 Histidine 14 modulates membrane binding and neurotoxicity of the Alzheimer's disease amyloid-beta peptide. J Alzheimers Dis 2010 0.77
112 Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease. Angew Chem Int Ed Engl 2013 0.77
113 Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics 2013 0.77
114 Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study. Proteins 2013 0.76
115 Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport 2002 0.76
116 Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease. Acta Crystallogr Sect F Struct Biol Cryst Commun 2004 0.76
117 Small angle X-ray scattering analysis of Cu(2+)-induced oligomers of the Alzheimer's amyloid β peptide. Metallomics 2015 0.75
118 Conformational behavior and aggregation of ataxin-3 in SDS. PLoS One 2013 0.75
119 Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation. Free Radic Biol Med 2007 0.75
120 Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage. Eur J Biochem 2003 0.75
121 Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function. Metallomics 2014 0.75