Published in Cell Cycle on April 02, 2008
Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer (2010) 6.81
Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones (2010) 1.69
Hsp90, an unlikely ally in the war on cancer. FEBS J (2013) 1.33
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits. BMC Cell Biol (2010) 1.18
Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci. J Biol Chem (2012) 1.10
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A (2012) 1.01
Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg Med Chem (2011) 0.97
The Mysterious Ways of ErbB2/HER2 Trafficking. Membranes (Basel) (2014) 0.96
Targeting the heat shock protein 90 dimer with dimeric inhibitors. J Med Chem (2011) 0.91
Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells. Cell Stress Chaperones (2008) 0.86
The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness. J Biol Chem (2011) 0.83
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer. Cancers (Basel) (2014) 0.82
Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. J Biol Chem (2012) 0.82
Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors. Invest New Drugs (2015) 0.80
DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation. PLoS One (2013) 0.79
The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer. PLoS One (2011) 0.79
Exosomes in cancer theranostic: Diamonds in the rough. Cell Adh Migr (2017) 0.75
Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule. Int J Mol Sci (2015) 0.75
The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells. Am J Cancer Res (2015) 0.75
Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci (2017) 0.75
A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem (2007) 1.55
Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system. J Biol Chem (2004) 1.30
Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits. BMC Cell Biol (2010) 1.18
Monoclonal antibody 4C5 immunostains human melanomas and inhibits melanoma cell invasion and metastasis. Clin Cancer Res (2007) 1.08
BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage. Eur J Neurosci (2004) 0.90
Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion. PLoS One (2012) 0.88
Inhibiting matrix metalloproteinases, an old story with new potentials for cancer treatment. Anticancer Agents Med Chem (2012) 0.83
The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer. PLoS One (2011) 0.79
The 4C5 antigen is associated with Schwann cell migration during development and regeneration of the rat peripheral nervous system. Glia (2004) 0.77
Functional implications of HNK-1 expression on invasive behaviour of melanoma cells. Tumour Biol (2008) 0.76