| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Central nicotinic receptors: structure, function, ligands, and therapeutic potential.
|
ChemMedChem
|
2007
|
1.36
|
|
2
|
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation.
|
Bioorg Med Chem
|
2005
|
1.26
|
|
3
|
DNA interaction with Ru(II) and Ru(II)/Cu(II) complexes containing azamacrocycle and dppz residues. A thermodynamic, kinetic and theoretical study.
|
Dalton Trans
|
2010
|
1.09
|
|
4
|
Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA.
|
ACS Chem Biol
|
2012
|
0.85
|
|
5
|
The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1.
|
Nucleic Acids Res
|
2012
|
0.84
|
|
6
|
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
|
J Med Chem
|
2006
|
0.84
|
|
7
|
Insights into the conformational switching mechanism of the human vascular endothelial growth factor receptor type 2 kinase domain.
|
J Chem Inf Model
|
2012
|
0.81
|
|
8
|
X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).
|
Chem Commun (Camb)
|
2011
|
0.79
|
|
9
|
Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families.
|
Chemistry
|
2009
|
0.78
|
|
10
|
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptor antagonists.
|
Chem Pharm Bull (Tokyo)
|
2008
|
0.78
|
|
11
|
Insights into docking and scoring neuronal alpha4beta2 nicotinic receptor agonists using molecular dynamics simulations and QM/MM calculations.
|
J Comput Chem
|
2009
|
0.77
|
|
12
|
Tuning the activity of Zn(II) complexes in DNA cleavage: clues for design of new efficient metallo-hydrolases.
|
Inorg Chem
|
2008
|
0.77
|
|
13
|
Selective binding and fluorescence sensing of diphosphate in H2O via Zn(2+)-induced allosteric regulation of the receptor structure.
|
Chem Commun (Camb)
|
2011
|
0.77
|
|
14
|
A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
|
J Med Chem
|
2005
|
0.77
|
|
15
|
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands.
|
Bioorg Med Chem
|
2008
|
0.76
|
|
16
|
Modeling and biological investigations of an unusual behavior of novel synthesized acridine-based polyamine ligands in the binding of double helix and G-quadruplex DNA.
|
ChemMedChem
|
2010
|
0.76
|
|
17
|
Field interaction and geometrical overlap: a new simplex and experimental design based computational procedure for superposing small ligand molecules.
|
J Med Chem
|
2003
|
0.76
|
|
18
|
Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.
|
J Med Chem
|
2003
|
0.75
|
|
19
|
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).
|
J Med Chem
|
2017
|
0.75
|
|
20
|
DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit.
|
Chemistry
|
2008
|
0.75
|
|
21
|
Metal ion binding by a G-2 poly(ethylene imine) dendrimer. Ion-directed self-assembling of hierarchical mono- and two-dimensional nanostructured materials.
|
Inorg Chem
|
2013
|
0.75
|
|
22
|
Anion and ion-pair binding by a G-2 poly(ethylene imine) dendrimer.
|
Dalton Trans
|
2013
|
0.75
|
|
23
|
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.
|
Bioorg Med Chem
|
2010
|
0.75
|
|
24
|
Binding of H+ and Zn(II) ions with a new fluorescent macrocyclic phenanthrolinophane.
|
Dalton Trans
|
2010
|
0.75
|
|
25
|
A highly pH-sensitive Zn(II) chemosensor.
|
Dalton Trans
|
2010
|
0.75
|