Published in J Org Chem on May 10, 2008
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Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science (2009) 10.21
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res (2010) 6.65
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Res (2011) 4.75
Relationship of lipid rafts to transient confinement zones detected by single particle tracking. Biophys J (2002) 3.70
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature (2002) 3.67
High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol (2012) 3.61
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology (2007) 3.29
R gene expression induced by a type-III effector triggers disease resistance in rice. Nature (2005) 3.25
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res (2003) 3.09
Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res (2013) 2.99
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res (2009) 2.74
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (2002) 2.45
Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate. Am J Obstet Gynecol (2013) 2.36
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Disruption of tumor neovasculature by microbubble enhanced ultrasound: a potential new physical therapy of anti-angiogenesis. Ultrasound Med Biol (2011) 2.18
Rice xa13 recessive resistance to bacterial blight is defeated by induction of the disease susceptibility gene Os-11N3. Plant Cell (2010) 2.15
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol (2004) 2.10
Drug delivery and transport to solid tumors. Pharm Res (2003) 2.05
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. Mod Pathol (2011) 2.02
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer (2011) 2.01
Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J Biol Chem (2006) 1.99
MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation (2007) 1.83
Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest (2007) 1.79
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet (2012) 1.77
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope. Proc Natl Acad Sci U S A (2005) 1.74
Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. Biochem Biophys Res Commun (2005) 1.74
Two type III effector genes of Xanthomonas oryzae pv. oryzae control the induction of the host genes OsTFIIAgamma1 and OsTFX1 during bacterial blight of rice. Proc Natl Acad Sci U S A (2007) 1.71
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J (2005) 1.67
Lignin metabolism has a central role in the resistance of cotton to the wilt fungus Verticillium dahliae as revealed by RNA-Seq-dependent transcriptional analysis and histochemistry. J Exp Bot (2011) 1.67
Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway. Hepatology (2010) 1.66
Changes in spleen size in patients with acute ischemic stroke: a pilot observational study. Int J Stroke (2012) 1.66
BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med (2012) 1.61
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters. Proc Natl Acad Sci U S A (2013) 1.60
Using the epigenetic field defect to detect prostate cancer in biopsy negative patients. J Urol (2012) 1.60
Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis (2009) 1.59
A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica). Nat Genet (2013) 1.58
5-(Methoxy-carbon-yl)thio-phene-2-carboxylic acid. Acta Crystallogr Sect E Struct Rep Online (2009) 1.57
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer. Cancer Chemother Pharmacol (2012) 1.57
Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls. Carcinogenesis (2012) 1.57
Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila) (2013) 1.56
CpG island hypermethylation frequently silences FILIP1L isoform 2 expression in prostate cancer. J Urol (2012) 1.56
Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences. Drug Metab Dispos (2011) 1.54
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A (2013) 1.54
Synthesizing a novel genetic sequential logic circuit: a push-on push-off switch. Mol Syst Biol (2010) 1.52
Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. Cancer Res (2006) 1.52
Novel fusion transcripts associate with progressive prostate cancer. Am J Pathol (2014) 1.51
Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J Clin Pharmacol (2007) 1.51
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem (2008) 1.50
microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells. J Ovarian Res (2014) 1.50
Auxin controls seed dormancy through stimulation of abscisic acid signaling by inducing ARF-mediated ABI3 activation in Arabidopsis. Proc Natl Acad Sci U S A (2013) 1.50
Nitrogen-doped graphene quantum dots with oxygen-rich functional groups. J Am Chem Soc (2011) 1.46
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1. Biochem J (2013) 1.45
Airborne particulate matter from livestock production systems: a review of an air pollution problem. Environ Pollut (2009) 1.44
Knowledge and personal use of menopausal hormone therapy among Chinese obstetrician-gynecologists: results of a survey. Menopause (2014) 1.44
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem (2010) 1.44
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem (2002) 1.43
Transvenous phrenic nerve stimulation in patients with Cheyne-Stokes respiration and congestive heart failure: a safety and proof-of-concept study. Chest (2012) 1.43
Cohort Profile: The China Jintan Child Cohort Study. Int J Epidemiol (2009) 1.43
Host and pathogen factors controlling the rice-Xanthomonas oryzae interaction. Plant Physiol (2009) 1.41
Localized reentry as a novel type of the proarrhythmic effects of linear ablation in the left atrium. Pacing Clin Electrophysiol (2011) 1.41
A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells. Biochem Biophys Res Commun (2006) 1.41
The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med (2012) 1.41
Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci (2006) 1.40
Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion. Cancer Res (2007) 1.39
Methods to measure the lateral diffusion of membrane lipids and proteins. Methods (2006) 1.39
Effect of plasma treatment on multi-walled carbon nanotubes for the detection of H2S and SO2. Sensors (Basel) (2012) 1.39
Long-term outcome following ablation of atrial tachycardias occurring after mitral valve replacement in patients with rheumatic heart disease. Pacing Clin Electrophysiol (2013) 1.39
Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano (2013) 1.39
Comparison of the sensitivity and specificity of 5 image sets of dual-energy computed tomography for detecting first-pass myocardial perfusion defects compared with positron emission tomography. Medicine (Baltimore) (2014) 1.38
Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. Cardiology (2015) 1.38
Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives. Bioorg Med Chem (2007) 1.35
An electrochemical avenue to green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics. Adv Mater (2010) 1.34
Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides. J Cell Biol (2006) 1.34
Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies. J Virol (2004) 1.32
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. EMBO J (2002) 1.28
Phacoemulsification induced transient swelling of corneal Descemet's Endothelium Complex imaged with ultra-high resolution optical coherence tomography. PLoS One (2013) 1.26
pNovo: de novo peptide sequencing and identification using HCD spectra. J Proteome Res (2010) 1.25
Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36 kindreds. Medicine (Baltimore) (2002) 1.25
IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. Brain Res (2010) 1.24
Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos (2004) 1.24
ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel. BMC Cancer (2008) 1.24
All-graphene core-sheath microfibers for all-solid-state, stretchable fibriform supercapacitors and wearable electronic textiles. Adv Mater (2013) 1.24
Different immunoaffinity fractionation strategies to characterize the human plasma proteome. J Proteome Res (2006) 1.23
Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer. PLoS One (2012) 1.22
Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions. J Lipid Res (2010) 1.21
Helicobacter pylori infection appears the prime risk factor for stomach cancer. Int J Cancer (2006) 1.20
Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells. Breast Cancer Res (2014) 1.19
Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking. J Invest Dermatol (2005) 1.18
Improved peptide identification for proteomic analysis based on comprehensive characterization of electron transfer dissociation spectra. J Proteome Res (2010) 1.18
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia. Proc Natl Acad Sci U S A (2013) 1.17
Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the Japanese population. PLoS One (2012) 1.17
Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. Arthritis Rheum (2011) 1.16