Published in Trends Mol Med on May 14, 2008
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
The genetics and epigenetics of autoimmune diseases. J Autoimmun (2009) 1.40
The multiple faces of autoimmune-mediated bone loss. Nat Rev Endocrinol (2010) 1.22
Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther (2012) 1.19
The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. J Cell Biol (2010) 1.13
Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells. Am J Hum Genet (2010) 1.07
Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery. Mol Biol Evol (2012) 0.92
Structural architecture of SNP effects on complex traits. Am J Hum Genet (2014) 0.85
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies. J Diabetes Res (2015) 0.78
Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype. Eur J Epidemiol (2015) 0.77
Transcriptome analysis of epigenetically modulated genome indicates signature genes in manifestation of type 1 diabetes and its prevention in NOD mice. PLoS One (2013) 0.76
The incidence of type 1 diabetes mellitus among 15-34 years aged Lithuanian population: 18-year incidence study based on prospective databases. BMC Public Health (2011) 0.76
Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin. Clin Exp Immunol (2014) 0.75
Induced pluripotent stem cell modeling of complex genetic diseases. Drug Discov Today Dis Models (2012) 0.75
Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression. Mol Immunol (2013) 0.75
Recent advances in childhood diabetes mellitus. Ann Ib Postgrad Med (2008) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes (2008) 2.90
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease. Hum Genet (2013) 2.44
Rfx6 directs islet formation and insulin production in mice and humans. Nature (2010) 2.15
Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Neuro Oncol (2009) 2.04
Exome sequencing: dual role as a discovery and diagnostic tool. Ann Neurol (2012) 1.89
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes (2002) 1.83
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81
Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing. Hum Mutat (2010) 1.76
A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J Biol Chem (2002) 1.61
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet (2011) 1.60
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes (2008) 1.56
Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes. Diabetes (2007) 1.52
Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes (2007) 1.38
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Hum Genet (2009) 1.20
Mechanisms of genetic susceptibility to type I diabetes: beyond HLA. Mol Genet Metab (2004) 1.16
Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines. Epigenetics (2010) 1.12
Safety profile of frequent short courses of oral glucocorticoids in acute pediatric asthma: impact on bone metabolism, bone density, and adrenal function. Pediatrics (2003) 1.12
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A (2006) 1.04
Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block. J Clin Endocrinol Metab (2004) 1.04
Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency. J Pediatr (2003) 1.03
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet (2005) 1.01
Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones. Diabetes (2006) 0.97
In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. Hum Mol Genet (2010) 0.97
Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes. Diabetes (2007) 0.95
Somatic point mutations occurring early in development: a monozygotic twin study. J Med Genet (2013) 0.95
Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes (2008) 0.94
Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms. BMC Genomics (2006) 0.93
The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect. J Clin Endocrinol Metab (2004) 0.90
Study of transcriptional effects in Cis at the IFIH1 locus. PLoS One (2010) 0.90
A cis-acting regulatory variant in the IL2RA locus. J Immunol (2009) 0.89
The TCF7L2 locus and type 1 diabetes. BMC Med Genet (2007) 0.89
Proinsulin expression by Hassall's corpuscles in the mouse thymus. Diabetes (2004) 0.88
Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals. Diabetes (2005) 0.87
Early onset diabetes mellitus. Tip or iceberg? Pediatr Diabetes (2004) 0.87
Monogenic and other unusual causes of diabetes mellitus. Pediatr Clin North Am (2005) 0.87
Immunogenetics of type 1 diabetes. Horm Res (2005) 0.86
Compensatory beliefs about glucose testing are associated with low adherence to treatment and poor metabolic control in adolescents with type 1 diabetes. Health Educ Res (2009) 0.85
Familial clustering strongly suggests that the phenotypic variation of the 8344 A>G lys mitochondrial tRNA mutation is encoded in cis. Ann Hum Genet (2012) 0.85
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem (2012) 0.82
Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR). J Autoimmun (2006) 0.82
Genome-wide search for exonic variants affecting translational efficiency. Nat Commun (2013) 0.82
Evaluation of conventional blood glucose monitoring as an indicator of integrated glucose values using a continuous subcutaneous sensor. Diabetes Care (2002) 0.81
Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. Autoimmunity (2013) 0.79
Exome diagnostics: already a reality? J Med Genet (2011) 0.79
Statistical significance in genetic association studies. Clin Invest Med (2010) 0.78
Differential expression pattern of ZAC in developing mouse and human pancreas. J Mol Histol (2011) 0.78
The effect of type 2 diabetes risk loci on insulin requirements in type 1 diabetes. Horm Res Paediatr (2012) 0.77
No association of type 1 diabetes with a functional polymorphism of the LRAP gene. Mol Immunol (2006) 0.77
Insulin auto-immunity: implications for the prevention of Type 1 diabetes mellitus. Expert Rev Clin Immunol (2009) 0.77
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency. Horm Res Paediatr (2016) 0.77
RFX6 is needed for the development and maintenance of the β-cell phenotype. Islets (2011) 0.76
Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells. Diabetes Metab Res Rev (2012) 0.76
The IRF5 polymorphism in type 1 diabetes. J Med Genet (2007) 0.76
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus. Autoimmunity (2013) 0.76
Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression. Mol Immunol (2013) 0.75
Expression profile of a clonal insulin-expressing epithelial cell in the thymus. Mol Immunol (2013) 0.75
Screening for novel lead compounds increasing insulin expression in medullary thymic epithelial cells. Eur J Pharmacol (2012) 0.75
[What is new in the genetics of type 2 diabetes]. Med Sci (Paris) (2008) 0.75
Self-antigen expression in thymic epithelial cells in Ifn-γ or Tnf-α deficiency. Cytokine (2013) 0.75
Special issue on structural genomic alterations: ready for prime time. J Med Genet (2011) 0.75