Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMC 2430964)

Published in BMC Microbiol on May 28, 2008

Authors

Jon S Blevins1, Kayla E Hagman, Michael V Norgard

Author Affiliations

1: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. jon.blevins@utsouthwestern.edu

Articles citing this

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol (2012) 3.52

Lipoproteins of bacterial pathogens. Infect Immun (2010) 1.73

Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi. Infect Immun (2008) 1.63

The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. PLoS Pathog (2015) 1.54

BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol (2009) 1.42

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Mol Microbiol (2009) 1.37

Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun (2008) 1.36

BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog (2011) 1.22

Borrelia burgdorferi RevA antigen binds host fibronectin. Infect Immun (2009) 1.21

BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle. J Infect Dis (2009) 1.18

The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol (2012) 1.16

A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proc Natl Acad Sci U S A (2009) 1.11

Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks. PLoS Pathog (2011) 1.08

Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity. Mol Microbiol (2011) 1.08

CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi. Infect Immun (2010) 1.07

Characterization of a conditional bosR mutant in Borrelia burgdorferi. Infect Immun (2009) 1.06

Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol (2009) 1.06

Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells. Infect Immun (2011) 1.06

Illuminating the roles of the Borrelia burgdorferi adhesins. Trends Microbiol (2013) 1.03

Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2010) 1.03

Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1. Infect Immun (2010) 1.00

Common and unique contributions of decorin-binding proteins A and B to the overall virulence of Borrelia burgdorferi. PLoS One (2008) 0.99

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol (2012) 0.97

Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian host. Infect Immun (2012) 0.95

Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi. Infect Immun (2010) 0.93

That's my story, and I'm sticking to it--an update on B. burgdorferi adhesins. Front Cell Infect Microbiol (2014) 0.91

Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi. Infect Immun (2009) 0.90

The early dissemination defect attributed to disruption of decorin-binding proteins is abolished in chronic murine Lyme borreliosis. Infect Immun (2013) 0.89

Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi. J Bacteriol (2012) 0.87

Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete. PLoS Pathog (2014) 0.87

Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun (2014) 0.86

BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle. Infect Immun (2010) 0.86

Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS. PLoS One (2014) 0.86

Analysis of Borrelia burgdorferi Surface Proteins as Determinants in Establishing Host Cell Interactions. Front Microbiol (2011) 0.86

RpoS regulates essential virulence factors remaining to be identified in Borrelia burgdorferi. PLoS One (2012) 0.85

Solution structure of decorin-binding protein A from Borrelia burgdorferi. Biochemistry (2012) 0.84

Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi. J Bacteriol (2010) 0.83

The novel heparin-binding motif in decorin-binding protein A from strain B31 of Borrelia burgdorferi explains the higher binding affinity. Biochemistry (2013) 0.82

CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. Infect Immun (2014) 0.81

Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi. PLoS One (2014) 0.81

The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis. Mol Microbiol (2015) 0.80

Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion. Front Immunol (2017) 0.80

Detection of established virulence genes and plasmids to differentiate Borrelia burgdorferi strains. Infect Immun (2012) 0.79

Decorin binding proteins of Borrelia burgdorferi promote arthritis development and joint specific post-treatment DNA persistence in mice. PLoS One (2015) 0.78

Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cell Microbiol (2015) 0.77

BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection. Infect Immun (2014) 0.77

Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infect Immun (2009) 0.77

Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferi. Infect Immun (2016) 0.77

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi. Microbiology (2014) 0.77

Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cell Microbiol (2015) 0.76

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A. Biochemistry (2015) 0.75

Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion. Front Immunol (2016) 0.75

Lyme disease: aetiopathogenesis, factors for disease development and control. Inflammopharmacology (2012) 0.75

Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence of Ft SchuS4 to Immunized Animals. Front Microbiol (2017) 0.75

Articles cited by this

Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev (1997) 10.52

Lyme borreliosis in selected strains and ages of laboratory mice. J Infect Dis (1990) 5.95

The emergence of Lyme disease. J Clin Invest (2004) 5.24

Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am J Pathol (1991) 4.59

Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proc Natl Acad Sci U S A (2001) 3.28

A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17

Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02

Adherence of Borrelia burgdorferi to the proteoglycan decorin. Infect Immun (1995) 2.96

Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi. Mol Microbiol (2001) 2.95

Efficient targeted mutagenesis in Borrelia burgdorferi. J Bacteriol (2000) 2.89

Decorin-binding adhesins from Borrelia burgdorferi. Mol Microbiol (1998) 2.85

The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82

Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues. Infect Immun (1994) 2.81

Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol Microbiol (1998) 2.68

Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets. Proc Natl Acad Sci U S A (1993) 2.36

Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect Immun (1998) 2.29

Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete. Mol Microbiol (2002) 2.28

Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23

aadA confers streptomycin resistance in Borrelia burgdorferi. J Bacteriol (2003) 2.22

Standardization of medium for culturing Lyme disease spirochetes. J Clin Microbiol (1993) 2.19

BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect Immun (2004) 2.08

Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00

Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice. J Immunol (1995) 1.96

RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94

Borrelia burgdorferi bind to epithelial cell proteoglycans. J Clin Invest (1994) 1.86

Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library. Mol Microbiol (1999) 1.82

Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol (2000) 1.81

Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface. Infect Immun (2002) 1.76

Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi. Infect Immun (2008) 1.67

bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A (2005) 1.66

DNA analysis of Borrelia burgdorferi NCH-1, the first northcentral U.S. human Lyme disease isolate. J Clin Microbiol (1992) 1.61

Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infect Immun (2006) 1.55

Analysis and comparison of plasmid profiles of Borrelia burgdorferi sensu lato strains. J Clin Microbiol (1995) 1.54

Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52

Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3. Proc Natl Acad Sci U S A (2003) 1.50

Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci U S A (2003) 1.50

Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect Immun (1995) 1.49

Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins. Infect Immun (2006) 1.48

Resistance to Lyme disease in decorin-deficient mice. J Clin Invest (2001) 1.46

Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Mol Microbiol (2005) 1.41

Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1995) 1.40

Expression of a luxS gene is not required for Borrelia burgdorferi infection of mice via needle inoculation. Infect Immun (2003) 1.32

Adherence of Borrelia burgdorferi. Identification of critical lysine residues in DbpA required for decorin binding. J Biol Chem (1999) 1.28

Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice. Infect Immun (1997) 1.27

Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors. J Clin Microbiol (2001) 1.26

Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes. Cell Microbiol (2007) 1.23

Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1. Infect Immun (2004) 1.22

Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato. Infect Immun (1998) 1.21

Fibronectin-binding activity in Borrelia burgdorferi1. Biochim Biophys Acta (1998) 1.17

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect Immun (2006) 1.13

Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices. Infect Immun (2004) 1.10

The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice. Infect Immun (2006) 1.05

Significant improvement of the recombinant Borrelia-specific immunoglobulin G immunoblot test by addition of VlsE and a DbpA homologue derived from Borrelia garinii for diagnosis of early neuroborreliosis. J Clin Microbiol (2003) 1.02

Decorin-binding sites in the adhesin DbpA from Borrelia burgdorferi: a synthetic peptide approach. J Biol Chem (2003) 1.02

Adhesion mechanisms of the Lyme disease spirochete, Borrelia burgdorferi. Curr Drug Targets Infect Disord (2001) 0.87

Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. Curr Opin Rheumatol (2002) 0.86

Articles by these authors

DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci U S A (2002) 3.82

OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38

Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02

The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82

The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2003) 2.31

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med (2003) 2.08

bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A (2005) 1.66

Characterization of Francisella tularensis outer membrane proteins. J Bacteriol (2006) 1.59

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology (2008) 1.46

Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol (2005) 1.44

BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol (2009) 1.42

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Anal Biochem (2010) 1.36

Central nervous system infection in congenital syphilis. N Engl J Med (2002) 1.35

Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). J Bacteriol (2006) 1.34

Expression of a luxS gene is not required for Borrelia burgdorferi infection of mice via needle inoculation. Infect Immun (2003) 1.32

Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis. Infect Immun (2008) 1.31

The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression. Reprod Sci (2009) 1.28

BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog (2011) 1.22

Regulation of expression of the paralogous Mlp family in Borrelia burgdorferi. Infect Immun (2003) 1.21

Characterization of fig operon mutants of Francisella novicida U112. FEMS Microbiol Lett (2008) 1.21

The crystal structure of Zn(II)-free Treponema pallidum TroA, a periplasmic metal-binding protein, reveals a closed conformation. J Bacteriol (2002) 1.21

Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi. Appl Environ Microbiol (2007) 1.16

A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proc Natl Acad Sci U S A (2009) 1.11

Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin. J Biol Chem (2006) 1.10

The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. J Biol Chem (2006) 1.09

Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks. PLoS Pathog (2011) 1.08

Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol (2009) 1.06

Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. J Infect Dis (2007) 1.06

Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein. J Biol Chem (2002) 0.98

The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease. Infect Immun (2004) 0.97

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol (2012) 0.97

IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensis. Infect Immun (2013) 0.96

Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol (2007) 0.95

Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter. J Mol Biol (2012) 0.94

Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi. Mol Microbiol (2008) 0.93

Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi. Infect Immun (2008) 0.93

Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes. MBio (2013) 0.92

Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein. J Biol Chem (2004) 0.90

Skim milk enhances the preservation of thawed -80 degrees C bacterial stocks. J Microbiol Methods (2008) 0.87

Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT). J Mol Biol (2012) 0.87

Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol (2010) 0.86

The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis. J Biol Chem (2013) 0.84

The Tp38 (TpMglB-2) lipoprotein binds glucose in a manner consistent with receptor function in Treponema pallidum. J Bacteriol (2004) 0.84

Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis. J Bacteriol (2012) 0.83

Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi. J Bacteriol (2010) 0.83

Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter. Protein Sci (2013) 0.82

CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. Infect Immun (2014) 0.81

Method for the isolation of Francisella tularensis outer membranes. J Vis Exp (2010) 0.81

Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins. Microbes Infect (2007) 0.80

Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses. Protein Sci (2014) 0.78

Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.78

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi. Microbiology (2014) 0.77

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi. Microbiology (2015) 0.77