CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.

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Published in Blood on June 03, 2008

Authors

Brian Kavanagh1, Shaun O'Brien, David Lee, Yafei Hou, Vivian Weinberg, Brian Rini, James P Allison, Eric J Small, Lawrence Fong

Author Affiliations

1: Department of Microbiology and Immunology, Division of Hematology/Oncology, University of California, San Francisco, CA 94143, USA.

Associated clinical trials:

Ipilimumab and Sargramostim in Treating Patients With Metastatic Prostate Cancer | NCT00064129

Granulocyte Macrophage-Colony Stimulating Factor and Ipilimumab as Therapy in Melanoma (GIPI) | NCT01363206

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