PubRank

Laura J Niedernhofer

Author PubWeight™ 59.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ERCC1 and non-small-cell lung cancer. N Engl J Med 2007 2.22
2 Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol 2007 2.21
3 First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am J Hum Genet 2007 2.14
4 Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res 2009 2.03
5 NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest 2012 1.91
6 ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol 2008 1.88
7 Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 2008 1.76
8 XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol 2009 1.50
9 Mouse models of Fanconi anemia. Mutat Res 2009 1.49
10 Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease. DNA Repair (Amst) 2011 1.49
11 Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res 2006 1.43
12 Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J 2005 1.42
13 Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012 1.37
14 DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res 2013 1.31
15 The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 2012 1.30
16 A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology 2012 1.29
17 NF-κB in Aging and Disease. Aging Dis 2011 1.28
18 Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. PLoS Genet 2010 1.25
19 Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol 2003 1.20
20 The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. J Biol Chem 2009 1.18
21 Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis 2011 1.17
22 A quantitative assay for assessing the effects of DNA lesions on transcription. Nat Chem Biol 2012 1.16
23 Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J Am Chem Soc 2014 1.14
24 Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res 2013 1.13
25 Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep 2012 1.12
26 Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system. Spine J 2011 1.10
27 Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res 2010 1.08
28 Hyper telomere recombination accelerates replicative senescence and may promote premature aging. Proc Natl Acad Sci U S A 2010 1.05
29 Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med 2004 0.98
30 An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J Orthop Res 2013 0.95
31 NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther 2011 0.95
32 Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev 2011 0.94
33 ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine (Phila Pa 1976) 2012 0.94
34 XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. Clin Cancer Res 2011 0.93
35 DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell Metab 2013 0.92
36 Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion. Nucleic Acids Res 2012 0.91
37 Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. J Biol Chem 2012 0.89
38 Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces. Methods Mol Biol 2013 0.88
39 Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum. Gynecol Oncol 2012 0.86
40 ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer. Pharmgenomics Pers Med 2011 0.85
41 Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress. Aging (Albany NY) 2013 0.84
42 Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. Stem Cells 2013 0.84
43 Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: a Gynecologic Oncology Group study. Gynecol Oncol 2012 0.83
44 Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus 2011 0.82
45 Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model. Prostate 2011 0.80
46 Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer 2014 0.79
47 NF-κB activation with aging: characterization and therapeutic inhibition. Methods Mol Biol 2015 0.79
48 Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mech Ageing Dev 2012 0.78
49 Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell 2013 0.78
50 Fanconi anemia: a paradigm of discovering molecular pathways from patients. Mutat Res 2009 0.77
51 Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice. Neurobiol Dis 2011 0.76
52 Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine (Phila Pa 1976) 2017 0.75