Published in Br J Pharmacol on April 01, 1991
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia. Br J Pharmacol (1992) 0.81
Attenuation of contractions to acetylcholine in canine bronchi by an endogenous nitric oxide-like substance. Br J Pharmacol (1993) 0.79
Correlation between airway epithelium-induced relaxation of rat aorta in the co-axial bioassay and cyclic nucleotide levels. Br J Pharmacol (1992) 0.76
Some quantitative uses of drug antagonists. Br J Pharmacol Chemother (1959) 41.90
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther (1985) 9.91
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol (1990) 7.27
Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol (1989) 6.87
The nature of endothelium-derived vascular relaxant factor. Nature (1984) 5.53
Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 4.59
Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis (1989) 3.86
Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis (1988) 3.45
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis (1989) 3.06
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs. J Pharmacol Exp Ther (1975) 2.36
The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Br J Pharmacol (1986) 1.82
Binding of catecholamines to connective tissue and the effect upon the responses of blood vessels to noradrenaline and to nerve stimulation. J Physiol (1973) 1.63
Is asthma an epithelial disease? Am Rev Respir Dis (1984) 1.62
Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A (1985) 1.59
Endothelium-derived relaxing factor and the effects of acetylcholine and histamine on resistance blood vessels. Br J Pharmacol (1988) 1.59
Effects of peptidases on non-adrenergic, non-cholinergic inhibitory responses of tracheal smooth muscle: a comparison with effects on VIP- and PHI-induced relaxation. Br J Pharmacol (1989) 1.45
Selective generation of leukotriene B4 by tracheal epithelial cells from dogs. Biochem Biophys Res Commun (1983) 1.26
Epithelium-derived relaxing factor(s) and bronchial reactivity. Am Rev Respir Dis (1988) 1.21
Influence of epithelium on guinea pig airway responses to tachykinins: role of endopeptidase and cyclooxygenase. J Pharmacol Exp Ther (1989) 1.20
Tracheal epithelium releases a vascular smooth muscle relaxant factor: demonstration by bioassay. Eur J Pharmacol (1986) 1.19
Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea. Eur J Pharmacol (1987) 1.16
Co-axial bioassay of a smooth muscle relaxant factor released from guinea-pig tracheal epithelium. Br J Pharmacol (1989) 1.13
Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. J Pharmacol Exp Ther (1986) 1.10
Differential effects of epithelium removal on the responsiveness of guinea-pig tracheal smooth muscle to bronchoconstrictors. Br J Pharmacol (1987) 1.08
Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium. Involvement of an inhibitory metabolite of arachidonic acid. Am Rev Respir Dis (1987) 1.07
Airway epithelium-derived inhibitory factor. Trends Pharmacol Sci (1990) 1.05
Relaxation of cat tracheobronchial and pulmonary arterial smooth muscle by vasoactive intestinal peptide: lack of influence by peptidase inhibitors. Br J Pharmacol (1984) 1.05
Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion. J Biol Chem (1986) 1.03
Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am Rev Respir Dis (1989) 1.03
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi. J Pharmacol Exp Ther (1989) 1.01
Bronchial mucosal permeability and its relationship to airways hyperreactivity. J Allergy Clin Immunol (1981) 0.99
Morphological integrity of the bronchial epithelium in mild asthma. Thorax (1990) 0.98
Influence of epithelium on the responsiveness of guinea-pig isolated trachea to adenosine. Br J Pharmacol (1988) 0.96
The rat anococcygeus muscle is a convenient bioassay organ for the airway epithelium-derived relaxant factor. Eur J Pharmacol (1988) 0.95
Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium. J Pharmacol Exp Ther (1987) 0.95
Effect of hydrogen peroxide on guinea-pig tracheal smooth muscle in vitro: role of cyclo-oxygenase and airway epithelium. Br J Pharmacol (1989) 0.94
Pharmacological evaluation of a guinea-pig tracheal epithelium-derived inhibitory factor (EpDIF). Br J Pharmacol (1990) 0.94
The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle. Am Rev Respir Dis (1988) 0.91
Epithelium removal alters responsiveness of guinea pig trachea to substance P. J Appl Physiol (1985) (1989) 0.90
Effect of removal of epithelium on antigen-induced smooth muscle contraction and mediator release from guinea pig isolated trachea. J Pharmacol Exp Ther (1988) 0.89
Effect of human eosinophil major basic protein on ion transport in dog tracheal epithelium. Am Rev Respir Dis (1988) 0.87
Studies on the effects of viprostol in isolated small blood vessels and thoracic aorta of the rat. Br J Pharmacol (1988) 0.84
Epithelium-dependent relaxation of guinea-pig tracheal smooth muscle by carbachol. Arch Int Pharmacodyn Ther (1989) 0.79
Effects of L-serine borate on antagonism of leukotriene C4-induced contractions of guinea-pig trachea. Br J Pharmacol (1987) 0.78
Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J (2008) 5.38
Inflammatory mediators of asthma: an update. Pharmacol Rev (1998) 2.54
Inflammatory mediators and asthma. Pharmacol Rev (1988) 2.17
Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Am J Clin Nutr (1988) 1.96
Papillary thyroid carcinoma: the impact of therapy in 576 patients. Medicine (Baltimore) (1977) 1.92
Risk of pulmonary complications after elective abdominal surgery. Chest (1996) 1.84
Appendicitis: why so complicated? Analysis of 5755 consecutive appendectomies. Am Surg (2000) 1.64
Therapeutic uses of heparin beyond its traditional role as an anticoagulant. Trends Pharmacol Sci (1995) 1.58
Effects of preoperative chemotherapy on the morphology of resectable breast carcinoma. Mod Pathol (1996) 1.57
Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin. Br J Pharmacol (1983) 1.53
The platelet in asthma. Lancet (1984) 1.50
Is exploratory celiotomy necessary for all patients with truncal stab wounds? Arch Surg (1990) 1.47
Platelet-activating factor: a possible mediator of the dual response to allergen? Clin Allergy (1984) 1.45
Prospective clinical trial of a human tumor cloning system. Cancer Res (1983) 1.44
The incidence and risk of early postoperative small bowel obstruction. A cohort study. Am J Surg (1987) 1.44
A survey of the content of BSc courses in pharmacology in UK universities--is it time for a core curriculum? Trends Pharmacol Sci (1998) 1.43
Anatomy of a defective barrier: sequential glove leak detection in a surgical and dental environment. Crit Care Med (1992) 1.42
Guidelines for clinical care: anti-infective agents for intra-abdominal infection. A Surgical Infection Society policy statement. Arch Surg (1992) 1.34
Incidence and hospital stay for cardiac and pulmonary complications after abdominal surgery. J Gen Intern Med (1995) 1.34
Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv Pharmacol (1999) 1.34
An in vivo model for studying platelet aggregation and disaggregation. Thromb Haemost (1982) 1.33
The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br J Pharmacol (1991) 1.28
A randomized clinical trial of total parenteral nutrition in malnourished surgical patients: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr (1988) 1.26
Platelet-activating factor as a mediator of allergic disease. J Allergy Clin Immunol (1988) 1.21
Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet (1987) 1.21
Endothelium-derived relaxing factor inhibits platelet aggregation in human whole blood in vitro and in the rat in vivo. Eur J Pharmacol (1988) 1.21
PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. Microcirc Endothelium Lymphatics (1984) 1.19
Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin. Br J Dermatol (1984) 1.17
Acute cholecystitis in the diabetic. A case-control study of outcome. Arch Surg (1988) 1.15
Adenosine receptors and asthma. Br J Pharmacol (2008) 1.14
Role of sex hormones in allergic inflammation in mice. Clin Exp Allergy (2007) 1.14
Complicated presentations of groin hernias. Am J Surg (1991) 1.13
Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. Br J Dermatol (1985) 1.13
The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. Eur J Pharmacol (1988) 1.11
Nutritional status: importance in predicting wound-healing after amputation. J Bone Joint Surg Am (1984) 1.08
Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience (2006) 1.07
Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma. Am J Respir Crit Care Med (1996) 1.07
The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. Br J Pharmacol (2001) 1.05
Antitussive drugs--past, present, and future. Pharmacol Rev (2014) 1.05
Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit. Br J Pharmacol (1991) 1.04
The effect of platelet activating factor on pulmonary beta-adrenoceptors. Br J Pharmacol (1987) 1.03
The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits. Am Rev Respir Dis (1990) 1.03
Theophylline--an immunomodulatory role in asthma? Am Rev Respir Dis (1993) 1.03
Complications of needle catheter jejunostomy in 2,022 consecutive applications. Am J Surg (1995) 1.02
Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway. Br J Pharmacol (1998) 1.02
Operative management of diverticular emergencies: strategies and outcomes. Arch Surg (2000) 1.01
Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis. Br J Pharmacol (1995) 1.00
In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A (1994) 0.99
Cirrhosis and alcoholism as pathogenetic factors in pigment gallstone formation. Ann Surg (1985) 0.99
Inhibition of bradykinin-induced bronchoconstriction in the guinea-pig by a synthetic B2 receptor antagonist. Br J Pharmacol (1989) 0.99
The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects. Eur Respir J (1997) 0.98
Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. Br J Pharmacol (1985) 0.98
Early postoperative jejunal feeding of elemental diet in gastrointestinal surgery. Am Surg (1981) 0.98
PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle. Br J Pharmacol (1990) 0.97
Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. Am Rev Respir Dis (1988) 0.97
Increased platelet aggregation in vivo in the Zucker Diabetic Fatty rat: differences from the streptozotocin diabetic rat. Br J Pharmacol (2006) 0.96
The effect of inhaled heparin and related glycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs. Pulm Pharmacol (1997) 0.95
The involvement of platelets in non-thrombotic processes. Trends Pharmacol Sci (1988) 0.95
Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. Br J Pharmacol (1990) 0.94
RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol (2003) 0.94
The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration. J Lipid Mediat (1993) 0.94
Cromoglycate (DSCG) inhibits responses to platelet-activating factor (PAF-acether) in man: an alternative mode of action for DSCG in asthma? Eur J Pharmacol (1982) 0.94
Continuous monitoring of plasma protein extravasation and cell accumulation in vivo. Br J Dermatol (1983) 0.93
Effect of heparin and a low-molecular weight heparinoid on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol (1993) 0.93
Radioisotopic model for investigating thromboembolism in the rabbit. J Pharmacol Methods (1990) 0.93
Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma. Eur Respir J (1995) 0.92
Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. Br J Pharmacol (1987) 0.92
Pulmonary immune cells in health and disease: platelets. Eur Respir J (1994) 0.91
Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs. Br J Pharmacol (1992) 0.91
The role of phosphodiesterase enzymes in allergy and asthma. Adv Pharmacol (1998) 0.91
Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects. Eur Respir J (2007) 0.91
Complications of surgical endoscopy. A decade of experience from a surgical residency training program. Surg Endosc (1997) 0.90
Closure of the pelvic and perineal wounds after removal of the rectum and anus. Dis Colon Rectum (1980) 0.90
The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro. Br J Pharmacol (2000) 0.90
Pharmacological modulation of the respiratory and haematological changes accompanying active anaphylaxis in the guinea-pig. Eur J Pharmacol (1986) 0.90
Continual catheter administration of an elemental diet in infants and children. Surgery (1977) 0.90
Platelet accumulation induced by bacterial endotoxin in rats. Thromb Res (1996) 0.90
Platelets and bronchospasm. Int Arch Allergy Appl Immunol (1984) 0.89
The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. Am Rev Respir Dis (1988) 0.89
Cutaneous and pulmonary histopathological responses to platelet activating factor (Paf-acether) in the guinea-pig. J Pathol (1984) 0.89
A novel animal model for investigating persistent airway hyperresponsiveness. J Pharmacol Toxicol Methods (1993) 0.89
Heparin inhibits allergen-induced eosinophil infiltration into guinea-pig lung via a mechanism unrelated to its anticoagulant activity. Pulm Pharmacol Ther (2001) 0.88
Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen-induced airway responses in neonatally immunised rabbits. Br J Pharmacol (1996) 0.88
Modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, BN 52021. J Allergy Clin Immunol (1989) 0.88
The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits. Pulm Pharmacol Ther (2003) 0.88
Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs. Br J Pharmacol (1995) 0.88
Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma. J Allergy Clin Immunol (1993) 0.87
Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin. Eur J Pharmacol (2000) 0.87
Continual catheter administration of an elemental diet. Surg Gynecol Obstet (1976) 0.86
Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus. Br J Pharmacol (1995) 0.86
A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways. Life Sci (1998) 0.86
Experience with central high flow arteriovenous fistulas in patients requiring chronic parenteral chemotherapy or hemodialysis. Am J Surg (1978) 0.86
Capsaicin pre-treatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits. Eur J Pharmacol (1995) 0.86
Candidal abscess of the spleen in patients with acute leukemia. Surg Gynecol Obstet (1980) 0.86
Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle. Br J Pharmacol (2008) 0.85
Operations for peptic ulcer disease: paradigm lost. J Gastrointest Surg (2002) 0.85
Inhibition of serum-induced proliferation of bovine tracheal smooth muscle cells in culture by heparin and related glycosaminoglycans. Br J Pharmacol (1995) 0.85
Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol (1992) 0.85
The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice. Clin Exp Allergy (2000) 0.84
Platelets in asthma. Lancet (1985) 0.84