Published in Glia on October 01, 2008
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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease. Mol Neurodegener (2014) 0.85
Microglia as a critical player in both developmental and late-life CNS pathologies. Acta Neuropathol (2014) 0.84
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Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus. PLoS One (2014) 0.80
TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia. PLoS One (2015) 0.80
Differential modulation of TREM2 protein during postnatal brain development in mice. PLoS One (2013) 0.79
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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease. Alzheimers Res Ther (2016) 0.78
The evolving biology of microglia in Alzheimer's disease. Neurotherapeutics (2015) 0.77
TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus. Clin Epigenetics (2016) 0.76
Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2). J Neuroinflammation (2016) 0.76
The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease. Neurochem Res (2015) 0.75
Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease. Biomed Res Int (2017) 0.75
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Front Aging Neurosci (2017) 0.75
TREM2-ligand interactions in health and disease. J Mol Biol (2017) 0.75
The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability. Front Neurosci (2017) 0.75
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms. Front Mol Neurosci (2017) 0.75
CSF sTREM2: marking the tipping point between preclinical AD and dementia? EMBO Mol Med (2016) 0.75
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies. Front Aging Neurosci (2017) 0.75
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Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Retracted Generation of pluripotent stem cells from adult human testis. Nature (2008) 5.49
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J (2002) 3.81
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet (2010) 3.73
Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci (2004) 3.17
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Neuron (2006) 3.17
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci (2006) 3.05
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Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (2004) 3.01
Distinct gene set in two different lineages of ammonia-oxidizing archaea supports the phylum Thaumarchaeota. Trends Microbiol (2010) 2.84
TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain (2006) 2.80
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72
Sickle hemoglobin confers tolerance to Plasmodium infection. Cell (2011) 2.67
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J (2009) 2.37
The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics (2010) 2.37
Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. Cancer Res (2006) 2.36
Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci (2011) 2.31
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol (2009) 2.09
No effect of the transforming growth factor β1 promoter polymorphism C-509T on TGFB1 gene expression, protein secretion, or cellular radiosensitivity. Int J Radiat Oncol Biol Phys (2012) 2.06
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J (2005) 2.04
Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron (2005) 2.01
The perfect crime? CCSVI not leaving a trace in MS. J Neurol Neurosurg Psychiatry (2011) 1.96
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis (2006) 1.96
Corneal intrastromal tissue modeling with the femtosecond laser. Graefes Arch Clin Exp Ophthalmol (2011) 1.95
Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. J Neurosci (2005) 1.94
Migration of monocytes after intracerebral injection at entorhinal cortex lesion site. J Leukoc Biol (2012) 1.93
Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J (2009) 1.82
Parkinson patient fibroblasts show increased alpha-synuclein expression. Exp Neurol (2008) 1.79
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol (2006) 1.76
Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases. Brain (2010) 1.75
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem (2004) 1.75
Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection. J Immunol (2009) 1.74
Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J Mol Med (Berl) (2006) 1.73
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain (2009) 1.66
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron (2009) 1.64
Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantation. Ann Thorac Surg (2006) 1.63
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci (2013) 1.62
Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits. Hum Mutat (2010) 1.59
CNS pericytes: concepts, misconceptions, and a way out. Glia (2010) 1.59
CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci (2004) 1.57
Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol (2009) 1.57
AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A (2009) 1.53
Perivascular spaces and the two steps to neuroinflammation. J Neuropathol Exp Neurol (2008) 1.52
Reversible cardiac sympathectomy by high thoracic epidural anesthesia improves regional left ventricular function in patients undergoing coronary artery bypass grafting: a randomized trial. Arch Surg (2003) 1.50
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet (2013) 1.48
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development (2005) 1.44
Assay-based response evaluation in head and neck oncology: requirements for better decision making. Eur Arch Otorhinolaryngol (2010) 1.44
The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations. Environ Microbiol (2012) 1.42
Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J (2006) 1.41
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7. Prog Neurobiol (2013) 1.40
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci (2003) 1.37
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci (2007) 1.34
Perivascular spaces--MRI marker of inflammatory activity in the brain? Brain (2008) 1.33
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32
Molecular karyotyping of patients with unexplained mental retardation by SNP arrays: a multicenter study. Hum Mutat (2009) 1.30
IDO expression in the brain: a double-edged sword. J Mol Med (Berl) (2007) 1.30
T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa. J Leukoc Biol (2006) 1.30
Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease. Neuroimage (2010) 1.26
On the structure of thiolate-protected Au25. J Am Chem Soc (2008) 1.22
CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol (2010) 1.21
Cone dystrophy with supernormal rod response is strictly associated with mutations in KCNV2. Invest Ophthalmol Vis Sci (2008) 1.20
Transcriptional changes in multiple system atrophy and Parkinson's disease putamen. Exp Neurol (2006) 1.20
Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response. Invest Ophthalmol Vis Sci (2007) 1.20
Blood-brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions. PLoS One (2013) 1.20
A rapid microarray based whole genome analysis for detection of uniparental disomy. Hum Mutat (2005) 1.19
Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci (2009) 1.17
Comparison of modified Thiel embalming and ethanol-glycerin fixation in an anatomy environment: Potentials and limitations of two complementary techniques. Anat Sci Educ (2014) 1.16
Array-based resequencing assay for mutations causing hypertrophic cardiomyopathy. Clin Chem (2008) 1.15
Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci (2012) 1.15
The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus. J Neurosci (2004) 1.15
Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med (Berl) (2008) 1.14
The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis. Mol Genet Metab (2005) 1.14
A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One (2010) 1.13
Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb Cortex (2010) 1.13
Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia (2010) 1.13
Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology (2010) 1.13
Microglial pathology. Acta Neuropathol Commun (2014) 1.13
Repetitive magnetic stimulation induces functional and structural plasticity of excitatory postsynapses in mouse organotypic hippocampal slice cultures. J Neurosci (2012) 1.12
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci (2006) 1.11
Divide and protect: capping gold nanoclusters with molecular gold-thiolate rings. J Phys Chem B (2006) 1.10
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci (2002) 1.09
The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia (2008) 1.08
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One (2010) 1.08
Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. Ann Neurol (2007) 1.08
Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun (2007) 1.07
Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Hum Mol Genet (2008) 1.07
3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse. Hippocampus (2008) 1.06
New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease). Curr Opin Neurol (2008) 1.06
Large deletions of the KCNV2 gene are common in patients with cone dystrophy with supernormal rod response. Hum Mutat (2011) 1.06
Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol (2003) 1.06
A role for the spine apparatus in LTP and spatial learning. Behav Brain Res (2008) 1.06
High-throughput resequencing in the diagnosis of BRCA1/2 mutations using oligonucleotide resequencing microarrays. Breast Cancer Res Treat (2009) 1.05