|
1
|
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
|
Proc Natl Acad Sci U S A
|
2007
|
9.82
|
|
2
|
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
|
Blood
|
2009
|
5.87
|
|
3
|
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.
|
Cell
|
2010
|
4.07
|
|
4
|
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine.
|
Proc Natl Acad Sci U S A
|
2010
|
3.86
|
|
5
|
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.
|
Cancer Cell
|
2005
|
3.44
|
|
6
|
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
|
J Clin Invest
|
2006
|
3.27
|
|
7
|
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
|
J Clin Invest
|
2007
|
2.91
|
|
8
|
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
|
J Clin Oncol
|
2007
|
2.64
|
|
9
|
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.
|
Nat Genet
|
2005
|
2.63
|
|
10
|
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons.
|
Proc Natl Acad Sci U S A
|
2006
|
2.61
|
|
11
|
Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.
|
Immunity
|
2006
|
2.56
|
|
12
|
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.
|
Blood
|
2004
|
2.37
|
|
13
|
Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain.
|
Pain
|
2004
|
2.10
|
|
14
|
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.
|
Cancer Cell
|
2012
|
2.01
|
|
15
|
CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets.
|
Blood
|
2009
|
1.94
|
|
16
|
The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.
|
Blood
|
2005
|
1.73
|
|
17
|
Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method.
|
Nucleic Acids Res
|
2007
|
1.62
|
|
18
|
Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.
|
J Neurosci
|
2002
|
1.62
|
|
19
|
Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
|
J Clin Oncol
|
2010
|
1.59
|
|
20
|
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine.
|
Ann Neurol
|
2007
|
1.56
|
|
21
|
Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes.
|
J Control Release
|
2006
|
1.45
|
|
22
|
Connexin mediates gap junction-independent resistance to cellular injury.
|
J Neurosci
|
2003
|
1.38
|
|
23
|
Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.
|
Mol Pharm
|
2009
|
1.37
|
|
24
|
RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia.
|
Blood
|
2012
|
1.33
|
|
25
|
Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity.
|
J Clin Oncol
|
2005
|
1.33
|
|
26
|
Curcumin is a potent DNA hypomethylation agent.
|
Bioorg Med Chem Lett
|
2008
|
1.31
|
|
27
|
Identification of reference genes for reverse transcription quantitative real-time PCR normalization in pepper (Capsicum annuum L.).
|
Biochem Biophys Res Commun
|
2011
|
1.31
|
|
28
|
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
|
J Clin Invest
|
2011
|
1.30
|
|
29
|
Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy.
|
Brain
|
2012
|
1.26
|
|
30
|
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
|
Glia
|
2005
|
1.22
|
|
31
|
Dose escalation of lenalidomide in relapsed or refractory acute leukemias.
|
J Clin Oncol
|
2010
|
1.20
|
|
32
|
Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.
|
Clin Cancer Res
|
2005
|
1.16
|
|
33
|
Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.
|
Brain
|
2006
|
1.15
|
|
34
|
Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy.
|
Exp Diabetes Res
|
2012
|
1.14
|
|
35
|
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.
|
Blood
|
2008
|
1.12
|
|
36
|
A LC-MS/MS method for the analysis of intracellular nucleoside triphosphate levels.
|
Pharm Res
|
2009
|
1.07
|
|
37
|
Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
|
PLoS One
|
2013
|
1.05
|
|
38
|
Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia.
|
Clin Cancer Res
|
2008
|
1.05
|
|
39
|
Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.
|
J Pharmacol Exp Ther
|
2005
|
1.04
|
|
40
|
Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing.
|
J Control Release
|
2009
|
1.02
|
|
41
|
TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia.
|
Blood
|
2009
|
1.01
|
|
42
|
Modulation of DNA methylation by a sesquiterpene lactone parthenolide.
|
J Pharmacol Exp Ther
|
2009
|
0.99
|
|
43
|
Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface.
|
J Neurosci
|
2004
|
0.99
|
|
44
|
Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines.
|
J Pharmacol Exp Ther
|
2005
|
0.99
|
|
45
|
Transcriptional control of human T-BET expression: the role of Sp1.
|
Eur J Immunol
|
2007
|
0.96
|
|
46
|
The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
|
Blood
|
2008
|
0.96
|
|
47
|
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
|
Clin Cancer Res
|
2008
|
0.95
|
|
48
|
Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells.
|
Mol Pharm
|
2007
|
0.95
|
|
49
|
Neuropathy-associated Nav1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons.
|
Ann Neurol
|
2012
|
0.94
|
|
50
|
Sodium channel activity modulates multiple functions in microglia.
|
Glia
|
2009
|
0.94
|
|
51
|
Histone H4 N-terminal acetylation in Kasumi-1 cells treated with depsipeptide determined by acetic acid-urea polyacrylamide gel electrophoresis, amino acid coded mass tagging, and mass spectrometry.
|
J Proteome Res
|
2007
|
0.94
|
|
52
|
Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2005
|
0.94
|
|
53
|
The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide.
|
Clin Cancer Res
|
2006
|
0.92
|
|
54
|
Analysis of TIR- and non-TIR-NBS-LRR disease resistance gene analogous in pepper: characterization, genetic variation, functional divergence and expression patterns.
|
BMC Genomics
|
2012
|
0.91
|
|
55
|
Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry.
|
Anal Biochem
|
2009
|
0.90
|
|
56
|
CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
|
J Immunol
|
2009
|
0.90
|
|
57
|
Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.
|
Blood
|
2013
|
0.90
|
|
58
|
Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelination.
|
J Neuropathol Exp Neurol
|
2010
|
0.89
|
|
59
|
Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
|
Proteomics
|
2010
|
0.89
|
|
60
|
Antitumor activity of G3139 lipid nanoparticles (LNPs).
|
Mol Pharm
|
2009
|
0.88
|
|
61
|
Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia.
|
Mol Pharm
|
2010
|
0.87
|
|
62
|
Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity.
|
Mol Pharm
|
2012
|
0.87
|
|
63
|
Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli.
|
Biochem Biophys Res Commun
|
2004
|
0.87
|
|
64
|
The pleiotropic SEPALLATA-like gene OsMADS34 reveals that the 'empty glumes' of rice (Oryza sativa) spikelets are in fact rudimentary lemmas.
|
New Phytol
|
2013
|
0.86
|
|
65
|
5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).
|
Biochem Biophys Res Commun
|
2006
|
0.86
|
|
66
|
Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid.
|
Int J Pharm
|
2010
|
0.85
|
|
67
|
Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma.
|
Melanoma Res
|
2005
|
0.85
|
|
68
|
Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model.
|
Pharm Res
|
2009
|
0.85
|
|
69
|
A novel ultrasensitive hybridization-based ELISA method for 2-methoxyphosphorothiolate microRNAs and its in vitro and in vivo application.
|
AAPS J
|
2010
|
0.83
|
|
70
|
Reactivation of RASSF1A in breast cancer cells by curcumin.
|
Nutr Cancer
|
2012
|
0.83
|
|
71
|
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.
|
J Biol Chem
|
2011
|
0.82
|
|
72
|
Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice.
|
Rheumatol Int
|
2010
|
0.81
|
|
73
|
Biochemical modulation of aracytidine (Ara-C) effects by GTI-2040, a ribonucleotide reductase inhibitor, in K562 human leukemia cells.
|
AAPS J
|
2010
|
0.80
|
|
74
|
A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases.
|
Int Urol Nephrol
|
2014
|
0.79
|
|
75
|
Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation.
|
Proteomics Clin Appl
|
2007
|
0.79
|
|
76
|
Ubiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells.
|
Biochemistry
|
2009
|
0.79
|
|
77
|
Efficient delivery of antisense oligodeoxyribonucleotide g3139 by human serum albumin-coated liposomes.
|
Mol Pharm
|
2009
|
0.78
|
|
78
|
Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia.
|
Glia
|
2014
|
0.78
|
|
79
|
A review of rodent models of peritoneal dialysis and its complications.
|
Int Urol Nephrol
|
2014
|
0.78
|
|
80
|
[Amifostin in protection of kidney from cisplatinum injury].
|
Zhonghua Zhong Liu Za Zhi
|
2002
|
0.77
|
|
81
|
Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesis.
|
Exp Neurol
|
2013
|
0.77
|
|
82
|
Ectopic expression of TrPI, a Taihangia rupestris (Rosaceae) PI ortholog, causes modifications of vegetative architecture in Arabidopsis.
|
J Plant Physiol
|
2010
|
0.77
|
|
83
|
Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis.
|
Neuroreport
|
2014
|
0.75
|
|
84
|
CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia.
|
Mol Pharm
|
2015
|
0.75
|
|
85
|
Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139.
|
Anticancer Res
|
2010
|
0.75
|
|
86
|
Estimating the brain pathological age of Alzheimer's disease patients from MR image data based on the separability distance criterion.
|
Phys Med Biol
|
2016
|
0.75
|
|
87
|
[Effect of serum leptin on nutritional status of patients with cancer].
|
Wei Sheng Yan Jiu
|
2002
|
0.75
|
|
88
|
Y2O3:Eu3+ core-in-multi-hollow microspheres: facile synthesis and luminescence properties.
|
J Nanosci Nanotechnol
|
2011
|
0.75
|
|
89
|
Fiber gyroscope with a double sensitivity employing a polarization splitter.
|
Opt Lett
|
2013
|
0.75
|