A cell-based approach to the minimization of immunosuppression in renal transplantation.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 18573141)

Published in Transpl Int on July 10, 2008

Authors

James A Hutchinson1, Beate G Brem-Exner, Paloma Riquelme, Dave Roelen, Maren Schulze, Katrin Ivens, Bernd Grabensee, Oliver Witzke, Thomas Philipp, Lutz Renders, Andreas Humpe, Anna Sotnikova, Martina Matthäi, Asmus Heumann, Felix Gövert, Thilo Schulte, Dieter Kabelitz, Frans H J Claas, Edward K Geissler, Ulrich Kunzendorf, Fred Fändrich

Author Affiliations

1: Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig-Holstein, Kiel, Germany. james.hutchinson@uksh-kiel.de

Articles citing this

Regulatory immune cells in transplantation. Nat Rev Immunol (2012) 1.82

IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Mol Ther (2012) 1.14

Clinical operational tolerance after renal transplantation: current status and future challenges. Ann Surg (2010) 1.08

Pathogenic and protective role of macrophages in kidney disease. Am J Physiol Renal Physiol (2013) 0.97

Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs. Transplant Res (2012) 0.92

Translating tolerogenic therapies to the clinic - where do we stand? Front Immunol (2012) 0.91

Tolerogenic therapies in transplantation. Front Immunol (2012) 0.88

Tolerance in clinical transplantation: progress, challenge or just a dream? Langenbecks Arch Surg (2011) 0.88

In question: the scientific value of preclinical safety pharmacology and toxicology studies with cell-based therapies. Mol Ther Methods Clin Dev (2014) 0.84

Regulatory myeloid cells in transplantation. Transplantation (2014) 0.83

Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits. Plast Reconstr Surg (2011) 0.83

The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and CD4(+)25(+)Foxp3+ regulatory T cells on skin allograft rejection. PLoS One (2013) 0.82

Translating transplantation tolerance in the clinic: where are we, where do we go? Clin Exp Immunol (2009) 0.78

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation. Front Immunol (2016) 0.77

Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms. Front Immunol (2016) 0.76

Tolerance--is it worth it? Cold Spring Harb Perspect Med (2014) 0.75

Transplantology: Challenges for Today. Arch Immunol Ther Exp (Warsz) (2017) 0.75

The long and winding road towards induction of allograft tolerance in the clinic. Transpl Int (2008) 0.75

Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation. Front Immunol (2017) 0.75

The exciting "bench to bedside" journey of cell therapies for acute kidney injury and renal transplantation. J Nephrol (2017) 0.75

Articles by these authors

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med (2002) 7.06

Everolimus in patients with autosomal dominant polycystic kidney disease. N Engl J Med (2010) 5.50

Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med (2015) 4.78

Early detection of acute renal failure by serum cystatin C. Kidney Int (2004) 4.62

Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells (2004) 3.98

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity (2004) 3.26

Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology (2002) 3.16

Augmentation index is associated with cardiovascular risk. J Hypertens (2002) 3.13

Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood (2010) 2.87

Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med (2009) 2.80

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet (2007) 2.75

Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res (2007) 2.71

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet (2010) 2.66

Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood (2003) 2.57

Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation (2013) 2.55

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int (2012) 2.55

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39

Posterior retroperitoneoscopic adrenalectomy--results of 560 procedures in 520 patients. Surgery (2006) 2.35

Regional citrate versus systemic heparin for anticoagulation in critically ill patients on continuous venovenous haemofiltration: a prospective randomized multicentre trial. Nephrol Dial Transplant (2010) 2.35

Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study. BMJ (2012) 2.32

Allo-HLA reactivity of virus-specific memory T cells is common. Blood (2010) 2.28

Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res (2007) 2.21

Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol (2008) 2.20

Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nat Med (2002) 2.20

Can arterial stiffness parameters be measured in the sitting position? Hypertens Res (2010) 2.11

Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin Chem (2004) 2.10

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10

Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function. J Immunol (2002) 1.98

Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice. Gut (2011) 1.84

Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study. J Am Coll Cardiol (2010) 1.82

Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Nephrol (2009) 1.82

Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation (2009) 1.82

Association of ambulatory arterial stiffness index and brachial pulse pressure is restricted to dippers. J Hypertens (2008) 1.77

Acute myocardial infarction in thrombotic microangiopathies--clinical characteristics, risk factors and outcome. Nephrol Dial Transplant (2006) 1.76

Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci U S A (2010) 1.72

Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol (2010) 1.71

Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure. Kidney Int (2010) 1.70

Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J Immunol (2007) 1.69

Pro- and anti-cancer effects of immunosuppressive agents used in organ transplantation. Transplantation (2004) 1.68

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med (2013) 1.68

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS One (2008) 1.67

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet (2010) 1.67

HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion. Blood (2013) 1.65

Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation (2006) 1.64

Efficacy and safety of a 7.5% icodextrin peritoneal dialysis solution in patients treated with automated peritoneal dialysis. Am J Kidney Dis (2002) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Can peripheral blood γδ T cells predict osteonecrosis of the jaw? An immunological perspective on the adverse drug effects of aminobisphosphonate therapy. J Bone Miner Res (2013) 1.59

Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial. Transplantation (2016) 1.59

The impact of living-related kidney transplantation on the donor's life. Transplantation (2006) 1.56

Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males. Cardiovasc Drugs Ther (2005) 1.55

Activation of V gamma 9V delta 2 T cells by NKG2D. J Immunol (2005) 1.54

IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology (2008) 1.51

Efficacy and safety of tacrolimus compared with cyclosporin A microemulsion in renal transplantation: 2 year follow-up results. Nephrol Dial Transplant (2005) 1.50

Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age. J Hypertens (2007) 1.49

Delayed seroconversion and rapid onset of lymphoproliferative disease after transmission of human T-cell lymphotropic virus type 1 from a multiorgan donor. Clin Infect Dis (2013) 1.48

Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One (2011) 1.47

Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility. Transplantation (2007) 1.44

No association between renin-angiotensin system gene polymorphisms and early and long-term allograft dysfunction in kidney transplant recipients. Nephrol Dial Transplant (2004) 1.43

High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice. J Gastroenterol Hepatol (2010) 1.42

Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice. Transplantation (2004) 1.40

Images in clinical medicine. Radiographic appearance of lanthanum. N Engl J Med (2006) 1.39

Biocompatibility of a bicarbonate/lactate-buffered PD fluid tested with a double-chamber cell culture system. Perit Dial Int (2005) 1.39

Selective decontamination of the digestive tract: impact on cytokine release and mucosal damage after hemorrhagic shock. Crit Care Med (2002) 1.39

gammadelta T cells link innate and adaptive immune responses. Chem Immunol Allergy (2005) 1.38

Synergism between lectins and vesicles of Viscum album L.- detection by biochemical and immunological methods. J Herb Pharmacother (2002) 1.38

Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes. J Immunol (2006) 1.38

Present status and perspectives of cell-based therapies for liver diseases. J Hepatol (2006) 1.33

Innate immune functions of human gammadelta T cells. Immunobiology (2007) 1.32

Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med (2012) 1.31

Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. Clin Cancer Res (2007) 1.30

Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer (2007) 1.30

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer (2011) 1.30

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther (2007) 1.29

Is presence of ANCA in crescentic IgA nephropathy a coincidence or novel clinical entity? A case series. Am J Kidney Dis (2009) 1.28

Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study. Transplant Res (2013) 1.27

Evaluation of the Eurotransplant Senior Program. The results of the first year. Am J Transplant (2002) 1.26

Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther (2011) 1.26

Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology (2005) 1.26

Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. Cancer Res (2008) 1.26

Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol (2011) 1.25

Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. Int J Cancer (2009) 1.25

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. J Clin Invest (2011) 1.25

Amyloidosis and bleeding: pathophysiology, diagnosis, and therapy. Am J Kidney Dis (2006) 1.24

Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. J Clin Invest (2006) 1.20

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci (2013) 1.20

New pathophysiological insights and treatment of ANCA-associated vasculitis. Kidney Int (2010) 1.19

GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice. Clin Exp Metastasis (2003) 1.19

Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF. Blood (2005) 1.17

Programmed necrosis in acute kidney injury. Nephrol Dial Transplant (2012) 1.17

Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl Int (2008) 1.17