Published in Biotechnol Bioeng on October 05, 1988
Scalable stirred-suspension bioreactor culture of human pluripotent stem cells. Tissue Eng Part A (2010) 1.44
Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci U S A (2004) 1.31
Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res (2001) 1.25
The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding. Cytotechnology (2011) 0.89
Characterization of product capture resin during microbial cultivations. J Ind Microbiol Biotechnol (2006) 0.78
A tracer liquid image velocimetry for multi-layer radial flow in bioreactors. Biomed Eng Online (2015) 0.75
Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions. Viruses (2016) 0.75
In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol (1993) 2.70
Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824. Biotechnology (N Y) (1992) 2.39
Thiolase from Clostridium acetobutylicum ATCC 824 and Its Role in the Synthesis of Acids and Solvents. Appl Environ Microbiol (1988) 2.31
The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain. J Bacteriol (1997) 2.15
Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models. Biophys J (2001) 2.09
Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824. J Bacteriol (1994) 1.87
Modeling pO(2) distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophys J (2001) 1.79
Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824. Microbiology (1996) 1.78
Molecular characterization of two Clostridium acetobutylicum ATCC 824 butanol dehydrogenase isozyme genes. J Bacteriol (1992) 1.77
Coenzyme A transferase from Clostridium acetobutylicum ATCC 824 and its role in the uptake of acids. Appl Environ Microbiol (1989) 1.73
Development and characterization of a gene expression reporter system for Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol (1999) 1.58
Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli. Appl Environ Microbiol (1990) 1.52
Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum. Appl Environ Microbiol (1999) 1.50
Cloning and expression of Clostridium acetobutylicum phosphotransbutyrylase and butyrate kinase genes in Escherichia coli. J Bacteriol (1988) 1.46
Phosphotransbutyrylase from Clostridium acetobutylicum ATCC 824 and its role in acidogenesis. Appl Environ Microbiol (1989) 1.45
Characterization of recombinant strains of the Clostridium acetobutylicum butyrate kinase inactivation mutant: need for new phenomenological models for solventogenesis and butanol inhibition? Biotechnol Bioeng (2000) 1.44
Sequence and arrangement of two genes of the butyrate-synthesis pathway of Clostridium acetobutylicum ATCC 824. Gene (1993) 1.43
Purification and characterization of the NADH-dependent butanol dehydrogenase from Clostridium acetobutylicum (ATCC 824). Arch Biochem Biophys (1989) 1.39
Regulation of the sol locus genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 by a putative transcriptional repressor. J Bacteriol (1999) 1.25
The effect of pH on nitrogen supply, cell lysis, and solvent production in fermentations of Clostridium acetobutylicum. Biotechnol Bioeng (1985) 1.16
Solventogenesis in Clostridium acetobutylicum fermentations related to carboxylic acid and proton concentrations. Biotechnol Bioeng (1988) 1.15
Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic acetone operon. Biotechnol Bioeng (1993) 1.14
Stoichiometric modeling of Clostridium acetobutylicum fermentations with non-linear constraints. J Biotechnol (1999) 1.13
Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. Exp Hematol (1992) 1.12
Characterization of hematopoietic cell expansion, oxygen uptake, and glycolysis in a controlled, stirred-tank bioreactor system. Biotechnol Prog (1998) 1.10
Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes. Br J Haematol (2000) 1.09
Metabolic flux analysis elucidates the importance of the acid-formation pathways in regulating solvent production by Clostridium acetobutylicum. Metab Eng (1999) 1.08
Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production. J Bacteriol (1994) 1.08
Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. J Ind Microbiol Biotechnol (2001) 1.06
Expression of Clostridium acetobutylicum ATCC 824 genes in Escherichia coli for acetone production and acetate detoxification. Appl Environ Microbiol (1998) 1.05
Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells. Biotechnology (N Y) (1993) 1.01
Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. Exp Hematol (1998) 1.00
Cloning of an NADH-dependent butanol dehydrogenase gene from Clostridium acetobutylicum. Ann N Y Acad Sci (1991) 0.97
Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2. Cytotherapy (2000) 0.97
Vector construction, transformation, and gene amplification in Clostridium acetobutylicum ATCC 824. Ann N Y Acad Sci (1992) 0.97
Higher pH promotes megakaryocytic maturation and apoptosis. Stem Cells (2002) 0.97
Culture materials affect ex vivo expansion of hematopoietic progenitor cells. J Biomed Mater Res (1997) 0.96
Hematopoietic cell culture therapies (Part I): Cell culture considerations. Trends Biotechnol (1996) 0.95
Physiologically significant effects of pH and oxygen tension on granulopoiesis. Exp Hematol (2000) 0.95
Genetic and metabolic engineering of Clostridium acetobutylicum ATCC 824. Ann N Y Acad Sci (1994) 0.94
Determination of plasmid copy number and stability in Clostridium acetobutylicum ATCC 824. FEMS Microbiol Lett (1993) 0.92
Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications. Biotechnol Bioeng (1998) 0.92
Low oxygen tension and autologous plasma enhance T-cell proliferation and CD49d expression density in serum-free media. Cytotherapy (2001) 0.92
Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner. Biotechnol Bioeng (1994) 0.91
Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment. Biotechnol Bioeng (1990) 0.91
pH is a potent modulator of erythroid differentiation. Br J Haematol (1998) 0.91
The lactate issue revisited: novel feeding protocols to examine inhibition of cell proliferation and glucose metabolism in hematopoietic cell cultures. Biotechnol Prog (2000) 0.90
Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes. Exp Hematol (2001) 0.90
Culture of human T cells in stirred bioreactors for cellular immunotherapy applications: shear, proliferation, and the IL-2 receptor. Biotechnol Bioeng (2000) 0.89
Effects of propionate and acetate additions on solvent production in batch cultures of Clostridium acetobutylicum. Appl Environ Microbiol (1990) 0.88
Studies of recombinant Clostridium acetobutylicum with increased dosages of butyrate formation genes. Ann N Y Acad Sci (1994) 0.88
Evaluation of cytokines for expansion of the megakaryocyte and granulocyte lineages. Stem Cells (1997) 0.87
Cloning, structure, and expression of acid and solvent pathway genes of Clostridium acetobutylicum. Biotechnology (1993) 0.86
Effects of synergistic cytokine combinations, low oxygen, and irradiated stroma on the expansion of human cord blood progenitors. Blood (1992) 0.86
Protection mechanisms of freely suspended animal cells (CRL 8018) from fluid-mechanical injury. Viscometric and bioreactor studies using serum, pluronic F68 and polyethylene glycol. Biotechnol Bioeng (1991) 0.85
Methods for cloning key primary metabolic enzymes and ancillary proteins associated with the acetone-butanol fermentation of Clostridium acetobutylicum. Ann N Y Acad Sci (1990) 0.84
Hematopoietic cell culture therapies (Part II): Clinical aspects and applications. Trends Biotechnol (1996) 0.84
Sparging and agitation-induced injury of cultured animals cells: Do cell-to-bubble interactions in the bulk liquid injure cells? Biotechnol Bioeng (1996) 0.84
Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells. Blood (1995) 0.83
Interfacial properties of cell culture media with cell-protecting additives. Biotechnol Bioeng (1995) 0.83
Development of novel perfusion chamber to retain nonadherent cells and its use for comparison of human "mobilized" peripheral blood mononuclear cell cultures with and without irradiated bone marrow stroma. Biotechnol Bioeng (1996) 0.83
Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6, and stem cell factor. Biotechnology (N Y) (1993) 0.83
Beneficial effects of reduced oxygen tension and perfusion in long-term hematopoietic cultures. Ann N Y Acad Sci (1992) 0.82
Equations and calculations for fermentations of butyric acid bacteria. Reprinted from Biotechnology and Bioengineering, Vol. XXVI, Pp 174-187 (1984). Biotechnol Bioeng (2000) 0.82
Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis. Br J Haematol (1997) 0.81
Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling. J Thromb Haemost (2014) 0.81
Shear sensitivity of hybridoma cells in batch, fed-batch, and continuous cultures. Biotechnol Prog (1990) 0.81
Extracellular pH affects the proliferation of cultured human T cells and their expression of the interleukin-2 receptor. J Immunother (2001) 0.81
Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications. Biotechnol Prog (1998) 0.81
Analysis of cell-to-bubble attachment in sparged bioreactors in the presence of cell-protecting additives. Biotechnol Bioeng (1995) 0.80
Polyvinyl alcohol and polyethylene glycol as protectants against fluid-mechanical injury of freely-suspended animal cells (CRL 8018). J Biotechnol (1991) 0.80
The protective effect of serum against hydrodynamic damage of hybridoma cells in agitated and surface-aerated bioreactors. J Biotechnol (1990) 0.80
Agitation induced cell injury in microcarrier cultures. Protective effect of viscosity is agitation intensity dependent: Experiments and modeling. Biotechnol Bioeng (1992) 0.80
Express together and conquer. Nat Biotechnol (1998) 0.80
Serum increases the CD13 receptor expression, reduces the transduction of fluid-mechanical forces, and alters the metabolism of HL60 cells cultured in agitated bioreactors. Biotechnol Bioeng (1998) 0.80
Ex vivo expansion of hematopoietic stem and progenitor cells for transplantation. Cancer Treat Res (1997) 0.79
Preface: Tissue engineering and cell therapies: II. Biotechnol Bioeng (1994) 0.79
Real-time method for determining the colony-forming cell content of human hematopoietic cell cultures. Biotechnol Bioeng (1997) 0.79
Cell aggregation in a Chinese hamster ovary cell microcarrier culture affects the expression rate and N-linked glycosylation of recombinant mouse placental lactogen-1. Ann N Y Acad Sci (1994) 0.79
Serum-free media for cultures of primitive and mature hematopoietic cells. Biotechnol Bioeng (1994) 0.79
Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in stirred tank bioreactors. Biotechnol Bioeng (1998) 0.79
Ex vivo expansion of primitive hematopoietic cells for cellular therapies: An overview. Cytotechnology (1995) 0.78
Population balance model of in vivo neutrophil formation following bone marrow rescue therapy. Cytotechnology (1998) 0.78
Decreasing extracellular pH increases CD13 receptor surface content and alters the metabolism of HL60 cells cultured in stirred tank bioreactors. Biotechnol Prog (1999) 0.78
Dynamic model of ex vivo granulocytic kinetics to examine the effects of oxygen tension, pH, and interleukin-3. Exp Hematol (2000) 0.78
Gas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol-acetone fermentation). Biotechnol Bioeng (1985) 0.78
Growth dynamics of a methylotroph (Methylomonas L3) in continuous cultures. II. Growth inhibition and comparison against an unstructured model. Biotechnol Bioeng (1987) 0.77
Growth dynamics of a methylotroph (Methylomonas L3) in continuous cultures. I. Fast transients induced by methanol pulses and methanol accumulation. Biotechnol Bioeng (1987) 0.77
Cell adhesion in animal cell culture: physiological and fluid-mechanical implications. Bioprocess Technol (1995) 0.77
Formation of bridges and large cellular clumps in CHO-cell microcarrier cultures: effects of agitation, dimethyl sulfoxide and calf serum. Cytotechnology (1992) 0.76
Fluid-mechanical forces in agitated bioreactors reduce the CD13 and CD33 surface protein content of HL60 cells. Biotechnol Bioeng (1993) 0.76
Damaging agitation intensities increase DNA synthesis rate and alter cell-cycle phase distributions of CHO cells. Biotechnol Bioeng (1992) 0.76
Modeling of contact-inhibited animal cell growth on flat surfaces and spheres. Biotechnol Bioeng (1989) 0.76
Ex-vivo expansion of CFU-GM and BFU-E in unselected PBMC cultures with Flt3L is enhanced by autologous plasma. Cytotherapy (1999) 0.76
Clinical-scale production of granulocyte progenitor and post-progenitor cells using daniplestim, leridistim, Progenipoietin, Promegapoietin and autologous plasma. Cytotherapy (2000) 0.75
Initiation, maintenance, and quantification of human hematopoietic cell cultures. Methods Mol Med (1999) 0.75
Direct measurement of carbon substrate oxidation and incorporation patterns in RuMP-type methylotrophs: Chemostatic cultures of Methylomonas L3. Biotechnol Bioeng (1985) 0.75
Comparison of whole serum-deprived media for ex vivo expansion of hematopoietic progenitor cells from cord blood and mobilized peripheral blood mononuclear cells. J Hematother (1996) 0.75
Ex vivo culture systems for hematopoietic cells. Curr Opin Biotechnol (1996) 0.75
Cell density-dependent proliferation in frequently-fed peripheral blood mononuclear cell cultures. Cytotherapy (2000) 0.75