PubRank

Thumbi Ndung'u

Author PubWeight™ 101.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Adaptation of HIV-1 to human leukocyte antigen class I. Nature 2009 4.24
2 Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS 2011 3.95
3 Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol 2008 2.72
4 Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients. J Exp Med 2009 2.39
5 HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load. J Virol 2008 2.14
6 Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design. Immunity 2013 2.00
7 Additive contribution of HLA class I alleles in the immune control of HIV-1 infection. J Virol 2010 1.97
8 Managing the demand for global health education. PLoS Med 2011 1.96
9 Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis 2005 1.82
10 Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. J Virol 2010 1.81
11 Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. PLoS Med 2013 1.66
12 Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana. AIDS 2006 1.66
13 Widespread impact of HLA restriction on immune control and escape pathways of HIV-1. J Virol 2012 1.62
14 Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome. AIDS 2013 1.46
15 Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C. J Virol 2011 1.45
16 HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control. J Virol 2011 1.31
17 HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. J Virol 2009 1.30
18 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription. J Exp Med 2010 1.27
19 Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations. PLoS One 2011 1.24
20 Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis. J Infect Dis 2009 1.21
21 Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection. J Virol 2009 1.20
22 Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity. J Virol 2012 1.20
23 HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703. J Immunol 2011 1.18
24 Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and cryptococcosis-associated immune reconstitution inflammatory syndrome. J Infect Dis 2013 1.18
25 Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics. PLoS One 2010 1.12
26 HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides. Immunogenetics 2010 1.11
27 Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. Clin Infect Dis 2011 1.09
28 Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting. Cerebrospinal Fluid Res 2009 1.08
29 APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load. AIDS 2010 1.08
30 Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population. Am J Respir Crit Care Med 2010 1.08
31 Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine. J Infect Dis 2013 1.06
32 Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells. J Immunol 2011 1.04
33 Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection. Virology 2006 1.04
34 Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa. Clin Infect Dis 2009 1.02
35 Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol 2010 1.02
36 Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology 2013 1.01
37 Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults. AIDS Res Hum Retroviruses 2010 1.01
38 HIV control through a single nucleotide on the HLA-B locus. J Virol 2012 1.00
39 Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection. J Infect Dis 2009 1.00
40 Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate. J Virol 2010 1.00
41 The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms. J Virol 2010 1.00
42 Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. PLoS One 2013 0.98
43 Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. J Infect Dis 2011 0.98
44 Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection. AIDS 2014 0.98
45 Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. AIDS 2011 0.97
46 Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial. J Acquir Immune Defic Syndr 2012 0.97
47 Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trial. AIDS 2012 0.96
48 Changes in Natural Killer cell activation and function during primary HIV-1 Infection. PLoS One 2013 0.96
49 Impact of blood processing variations on natural killer cell frequency, activation, chemokine receptor expression and function. J Immunol Methods 2011 0.96
50 Neutrophil counts in persons of African origin. Curr Opin Hematol 2014 0.94
51 Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands. AIDS 2010 0.93
52 Co-operative additive effects between HLA alleles in control of HIV-1. PLoS One 2012 0.93
53 Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. Virology 2006 0.92
54 Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection. J Infect Dis 2011 0.92
55 HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation. J Virol 2010 0.91
56 Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options. J Acquir Immune Defic Syndr 2011 0.91
57 Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-γ responses before antiretroviral therapy but not higher T-cell responses during therapy. J Infect Dis 2013 0.89
58 Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection. AIDS Res Hum Retroviruses 2011 0.89
59 Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope. J Virol 2012 0.89
60 Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality. Virology 2010 0.89
61 A molecular assay for sensitive detection of pathogen-specific T-cells. PLoS One 2011 0.88
62 Genetic characteristics, coreceptor usage potential and evolution of Nigerian HIV-1 subtype G and CRF02_AG isolates. PLoS One 2011 0.88
63 Rare HLA drive additional HIV evolution compared to more frequent alleles. AIDS Res Hum Retroviruses 2009 0.88
64 Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates. Virology 2009 0.87
65 Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa. AIDS Res Hum Retroviruses 2011 0.87
66 No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial. PLoS One 2013 0.86
67 Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. AIDS 2015 0.86
68 Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals. PLoS One 2012 0.85
69 Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population. Cell Host Microbe 2009 0.85
70 HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. J Virol 2013 0.85
71 Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. J Virol 2012 0.84
72 Drug resistance pattern of HIV type 1 isolates sampled in 2007 from therapy-naive pregnant women in North-Central Nigeria. AIDS Res Hum Retroviruses 2011 0.84
73 Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness. J Virol 2012 0.83
74 Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population. J Infect Dis 2011 0.83
75 HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression. Retrovirology 2010 0.83
76 Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT. AIDS Res Hum Retroviruses 2009 0.82
77 Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection. AIDS Res Hum Retroviruses 2010 0.82
78 Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection. Clin Infect Dis 2011 0.80
79 Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. J Virol 2011 0.80
80 HIV subtype influences HLA-B*07:02-associated HIV disease outcome. AIDS Res Hum Retroviruses 2013 0.80
81 TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. J Virol 2014 0.78
82 Comparative utility of cytokine levels and quantitative RD-1-specific T cell responses for rapid immunodiagnosis of tuberculous meningitis. J Clin Microbiol 2011 0.78
83 Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana. AIDS Behav 2012 0.77
84 Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection. AIDS 2014 0.77
85 HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective. AIDS 2013 0.76
86 Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes. AIDS 2016 0.75
87 Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. Virology 2012 0.75
88 Case records of the Massachusetts General Hospital. Case 18-2010. A 7-year-old boy with elevated HIV RNA levels despite antiretroviral medications. N Engl J Med 2010 0.75
89 Resistance fighter. Interview by Brendan Borrell. Sci Am 2012 0.75
90 Case records of the Massachusetts General Hospital. Case 15-2011. A 19-year-old South African woman with headache, fatigue, and vaginal discharge. N Engl J Med 2011 0.75