Published in Trends Neurosci on July 01, 2008
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89
Genome-wide association studies in ADHD. Hum Genet (2009) 2.58
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm (Vienna) (2008) 2.43
Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies. J Clin Invest (2009) 1.87
Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol (2011) 1.77
Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron (2010) 1.55
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc Natl Acad Sci U S A (2009) 1.49
Routes, destinations and delays: recent advances in AMPA receptor trafficking. Trends Neurosci (2011) 1.44
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry (2010) 1.28
Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci U S A (2009) 1.26
Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition. Mol Psychiatry (2011) 1.09
The dynamic cytoskeleton: backbone of dendritic spine plasticity. Curr Opin Neurobiol (2010) 1.07
Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. Schizophr Bull (2010) 1.07
Kalirin: a novel genetic risk factor for ischemic stroke. Hum Genet (2010) 1.07
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders. J Neurochem (2013) 1.05
A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis. PLoS One (2013) 1.01
Kalirin loss results in cortical morphological alterations. Mol Cell Neurosci (2009) 1.01
Abnormal kalirin signaling in neuropsychiatric disorders. Brain Res Bull (2013) 1.01
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry (2012) 1.00
The RhoGEF trio functions in sculpting class specific dendrite morphogenesis in Drosophila sensory neurons. PLoS One (2012) 0.99
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron (2015) 0.98
Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. J Neurosci (2013) 0.97
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines. Cytoskeleton (Hoboken) (2012) 0.93
Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. BMC Neurosci (2011) 0.93
Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Mol Cells (2014) 0.91
Neuronal Rho GEFs in synaptic physiology and behavior. Neuroscientist (2013) 0.91
Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell (2014) 0.91
Hippocampal phenotypes in kalirin-deficient mice. Mol Cell Neurosci (2010) 0.89
High-throughput single-cell manipulation in brain tissue. PLoS One (2012) 0.89
Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model. Neuropharmacology (2011) 0.89
COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch. PLoS One (2009) 0.89
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. J Biol Chem (2013) 0.89
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders. Curr Mol Med (2015) 0.89
Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization. J Neurosci (2013) 0.88
Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome. PLoS One (2009) 0.87
Neuregulin1 signaling promotes dendritic spine growth through kalirin. J Neurochem (2013) 0.85
A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness. Nat Commun (2014) 0.85
Multi-edge gene set networks reveal novel insights into global relationships between biological themes. PLoS One (2012) 0.85
Differential modulation of drug-induced structural and functional plasticity of dendritic spines. Mol Pharmacol (2012) 0.85
Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling. J Cell Sci (2009) 0.84
Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons. J Neurochem (2013) 0.82
Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens. Neuropharmacology (2014) 0.82
Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS One (2011) 0.82
Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior. Addict Biol (2012) 0.81
Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology. Commun Integr Biol (2011) 0.81
Long-term perturbation of spine plasticity results in distinct impairments of cognitive function. J Neurochem (2012) 0.80
Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts. J Biol Chem (2014) 0.79
Kalirin signaling: implications for synaptic pathology. Mol Neurobiol (2011) 0.79
The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis. Mol Cell Neurosci (2016) 0.76
The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation. PLoS One (2012) 0.76
Spatially restricted actin-regulatory signaling contributes to synapse morphology. J Neurochem (2012) 0.76
Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. Mol Biol Cell (2015) 0.75
Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients. BMC Med Genet (2012) 0.75
The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease. Mol Med (2017) 0.75
A Novel Bio-Psychosocial-Behavioral Treatment Model in Schizophrenia. Int J Mol Sci (2017) 0.75
Stimuli associated with the presence or absence of amphetamine regulate cytoskeletal signaling and behavior. Eur Neuropsychopharmacol (2016) 0.75
The phospholipid-binding protein SESTD1 negatively regulates dendritic spine density by interfering with Rac1-Trio8 signaling pathway. Sci Rep (2015) 0.75
An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio. Nat Commun (2017) 0.75
Structural basis of long-term potentiation in single dendritic spines. Nature (2004) 11.50
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry (2005) 9.23
Long-term dendritic spine stability in the adult cortex. Nature (2002) 7.47
The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu Rev Cell Dev Biol (2007) 6.91
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology (2004) 6.08
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat Neurosci (2006) 4.98
Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron (2004) 4.88
Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology (2007) 4.38
Molecular mechanisms of dendritic spine morphogenesis. Curr Opin Neurobiol (2005) 4.31
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues. Trends Neurosci (2006) 4.22
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. Nat Rev Neurosci (2008) 3.83
Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci (2007) 3.75
Neurobiology of schizophrenia. Neuron (2006) 3.69
Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol (2007) 3.63
Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci (2007) 3.47
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat Rev Neurosci (2005) 3.46
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron (2003) 3.40
Structural plasticity and memory. Nat Rev Neurosci (2004) 3.28
Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat Rev Neurosci (2004) 3.22
Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature (2003) 3.01
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci (2005) 2.96
Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Neuron (2007) 2.93
Dendritic spines and long-term plasticity. Nat Rev Neurosci (2005) 2.83
Spine architecture and synaptic plasticity. Trends Neurosci (2005) 2.79
Molecular mechanisms of dendritic spine development and remodeling. Prog Neurobiol (2005) 2.54
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron (2001) 2.52
Neuroplasticity of neocortical circuits in schizophrenia. Neuropsychopharmacology (2007) 2.51
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci (2005) 2.48
Integration of biochemical signalling in spines. Nat Rev Neurosci (2005) 2.31
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci (2004) 2.26
Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19
Calcium/calmodulin-dependent protein kinase II and synaptic plasticity. Curr Opin Neurobiol (2004) 2.14
Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Am J Psychiatry (2004) 2.11
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci (2006) 2.09
Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol (2008) 2.03
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol (2005) 2.02
Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol Psychiatry (2006) 1.99
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron (2008) 1.94
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A (2007) 1.91
The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A (2007) 1.88
TARPs and the AMPA receptor trafficking paradox. Neuron (2007) 1.83
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol (2004) 1.71
Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia. Mol Psychiatry (2006) 1.62
Kalirin, a multifunctional Rho guanine nucleotide exchange factor, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines. J Neurosci (2003) 1.60
The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron (2005) 1.57
The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. J Neurosci (2004) 1.54
An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction. J Biol Chem (2000) 1.50
Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron (2005) 1.50
Synaptic contact dynamics controlled by cadherin and catenins. Trends Cell Biol (2005) 1.47
Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun (2003) 1.47
Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry. J Neurosci (1991) 1.45
Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease. Biol Psychiatry (2004) 1.45
Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7. J Neurosci (2008) 1.44
Rac1 induces the clustering of AMPA receptors during spinogenesis. J Neurosci (2005) 1.43
Refining the roles of GABAergic signaling during neural circuit formation. Trends Neurosci (2007) 1.40
Growth of dendritic spines: a continuing story. Curr Opin Neurobiol (2005) 1.39
Transmitting on actin: synaptic control of dendritic architecture. J Cell Sci (2007) 1.37
The X11 proteins, Abeta production and Alzheimer's disease. Trends Neurosci (2006) 1.35
The neuropathology of autism: a review. J Neuropathol Exp Neurol (2005) 1.34
Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons. J Neurosci (2008) 1.33
Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site. J Biol Chem (2000) 1.31
Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice. Eur J Neurosci (2004) 1.27
Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience (2006) 1.21
Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist (2005) 1.21
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum Mol Genet (1997) 1.21
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol (2007) 1.19
The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J Neurosci (2005) 1.16
Kalirin is under-expressed in Alzheimer's disease hippocampus. J Alzheimers Dis (2007) 1.14
Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons. Ann N Y Acad Sci (2003) 1.14
ARF6 and EFA6A regulate the development and maintenance of dendritic spines. J Neurosci (2006) 1.13
Rho proteins, mental retardation and the neurobiological basis of intelligence. Prog Brain Res (2005) 1.11
Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat. J Comp Neurol (2001) 1.04
Reduction of AMPA-selective glutamate receptor subunits in the entorhinal cortex of patients with Alzheimer's disease pathology: a biochemical study. Brain Res (1995) 0.98
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. J Alzheimers Dis (2007) 0.95
Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons. Mol Cell Neurosci (2006) 0.83
Pumping up the synapse. Neuron (2007) 0.78
Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci (2011) 4.80
Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras. Blood (2008) 1.73
An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol (2012) 1.67
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci (2009) 1.58
Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity. Proc Natl Acad Sci U S A (2008) 1.47
Convergent CaMK and RacGEF signals control dendritic structure and function. Trends Cell Biol (2008) 1.38
Social, communication, and cortical structural impairments in Epac2-deficient mice. J Neurosci (2012) 1.02
Regulation of the actin cytoskeleton in dendritic spines. Adv Exp Med Biol (2012) 0.98
Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics. J Proteome Res (2012) 0.93
Afadin is required for maintenance of dendritic structure and excitatory tone. J Biol Chem (2012) 0.91
Epac2-mediated dendritic spine remodeling: implications for disease. Mol Cell Neurosci (2010) 0.90
Neuregulin1 signaling promotes dendritic spine growth through kalirin. J Neurochem (2013) 0.85
Potential prognostic biomarkers of pancreatic cancer. Pancreas (2014) 0.83
Donor major histocompatibility complex class I expression determines the outcome of prenatal transplantation. J Pediatr Surg (2008) 0.79
Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications. J Biol Chem (2014) 0.78
Quantitative analysis of Hedgehog gradient formation using an inducible expression system. BMC Dev Biol (2007) 0.78
A comparison of mental health outcomes in persons entering U.S. military service before and after September 11, 2001. J Trauma Stress (2012) 0.76
Individual augmentee deployment and newly reported mental health morbidity. J Occup Environ Med (2012) 0.75
Clinical analytics equal better systemwide outcomes. Nurs Manage (2007) 0.75
Safe management of mass fatalities following chemical, biological, and radiological incidents. Prehosp Disaster Med (2009) 0.75