Molecular polymorphism of Abeta in Alzheimer's disease.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 2842206)

Published in Neurobiol Aging on July 10, 2008

Authors

Harry Levine1, Lary C Walker

Author Affiliations

1: Department of Molecular and Cellular Biochemistry, Chandler School of Medicine and the Center on Aging, University of Kentucky, Lexington, KY, USA. hlevine@email.uky.edu

Articles citing this

The amyloid state of proteins in human diseases. Cell (2012) 4.53

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature (2013) 3.55

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol (2011) 2.94

The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nat Med (2010) 1.86

Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging (2014) 1.49

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol (2009) 1.42

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice. EMBO Rep (2013) 1.20

PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease. Neurobiol Aging (2009) 1.15

Nonhuman primate models of Alzheimer-like cerebral proteopathy. Curr Pharm Des (2012) 1.06

TDP-43 skeins show properties of amyloid in a subset of ALS cases. Acta Neuropathol (2012) 0.99

Corruption and spread of pathogenic proteins in neurodegenerative diseases. J Biol Chem (2012) 0.93

Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. PLoS One (2013) 0.89

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. Eur J Nucl Med Mol Imaging (2012) 0.83

In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [(18)F]flutemetamol. EJNMMI Res (2014) 0.82

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates. Chemistry (2015) 0.81

Context dependence of protein misfolding and structural strains in neurodegenerative diseases. Biopolymers (2013) 0.80

Computational modeling of the relationship between amyloid and disease. Biophys Rev (2012) 0.79

Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease. Neurobiol Aging (2016) 0.77

Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living Cells. Korean J Chem Eng (2012) 0.76

Articles cited by this

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol (2004) 21.56

Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology (2006) 8.97

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86

A general model of prion strains and their pathogenicity. Science (2007) 6.94

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (2006) 6.47

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain (2008) 5.89

Plaques, tangles and dementia. A quantitative study. J Neurol Sci (1982) 4.52

PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging (2007) 4.47

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol (2007) 4.11

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining. Acta Neuropathol (1988) 4.10

Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology (1988) 3.40

The structural basis of yeast prion strain variants. Nature (2007) 3.31

PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain (2007) 2.88

11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology (2007) 2.65

PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment. Neurology (2007) 2.63

Conformational Abs recognizing a generic amyloid fibril epitope. Proc Natl Acad Sci U S A (2002) 2.62

The state of the prion. Nat Rev Microbiol (2004) 2.60

Insights into prion strains and neurotoxicity. Nat Rev Mol Cell Biol (2007) 2.34

Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem (2006) 2.32

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Neurosci Lett (1988) 2.26

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes. ACS Chem Biol (2007) 2.18

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci (2003) 2.06

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease. Acta Neuropathol (1989) 1.93

The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol (2006) 1.91

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci (2007) 1.85

Conformation-dependent anti-amyloid oligomer antibodies. Methods Enzymol (2006) 1.72

Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol (1995) 1.69

Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody. Lab Invest (1989) 1.56

Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils. J Biol Chem (2004) 1.55

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies. J Neurosci (2007) 1.52

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J Biol Chem (2001) 1.49

Plasticity of amyloid fibrils. Biochemistry (2007) 1.43

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis (2007) 1.40

IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques. Brain Res (2002) 1.36

Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav Genet (2006) 1.33

Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging (2004) 1.21

APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry (2002) 1.18

Host and transmissible spongiform encephalopathy agent strain control glycosylation of PrP. J Gen Virol (1999) 1.18

Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Med (2007) 1.12

Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett (2005) 1.10

Multiple ligand binding sites on A beta(1-40) fibrils. Amyloid (2005) 1.05

Koch's postulates and infectious proteins. Acta Neuropathol (2006) 1.05

Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational states. Bioconjug Chem (2007) 1.03

Visualization and classification of amyloid beta supramolecular assemblies. Biochemistry (2007) 1.02

Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils. J Biol Chem (2005) 0.99

Solid-state NMR structural studies of the fibril form of a mutant mouse prion peptide PrP89-143(P101L). Solid State Nucl Magn Reson (2005) 0.99

Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol (2004) 0.95

Humoral immune response to fibrillar beta-amyloid peptide. Biochemistry (2003) 0.93

A pH-dependent conformational transition of Abeta peptide and physicochemical properties of the conformers in the glial cell. Biochem J (2002) 0.83

Y10W beta(1-40) fluorescence reflects epitope exposure in conformers of Alzheimer's beta-peptide. Arch Biochem Biophys (2003) 0.81

Articles by these authors

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (2006) 6.47

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature (2013) 3.55

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol (2011) 2.94

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci U S A (2009) 2.27

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics (2002) 1.75

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition. J Neurosci (2011) 1.66

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol (2007) 1.45

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol (2009) 1.42

The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2004) 1.42

The response of the aged brain to stroke: too much, too soon? Curr Neurovasc Res (2007) 1.39

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol (2010) 1.34

Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol (2008) 1.27

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats. J Neurochem (2011) 1.21

Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice. Brain Res (2006) 1.19

Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Neurosci Lett (2008) 1.19

PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease. Neurobiol Aging (2009) 1.15

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest (2011) 1.10

Nonhuman primate models of Alzheimer-like cerebral proteopathy. Curr Pharm Des (2012) 1.06

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathol (2011) 1.06

Aβ seeds resist inactivation by formaldehyde. Acta Neuropathol (2014) 1.03

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis. Acta Neuropathol (2012) 0.97

Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression? Neurosci Biobehav Rev (2009) 0.97

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem (2004) 0.95

Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically. BMC Neurosci (2008) 0.94

Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease. Acta Neuropathol (2006) 0.92

Amyloid by default. Nat Neurosci (2011) 0.91

Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2008) 0.88

Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Dis Assoc Disord (2004) 0.86

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. J Comp Neurol (2002) 0.85

SDS-PAGE/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrieval. J Vis Exp (2010) 0.85

The role of the ATP-binding cassette transporter P-glycoprotein in the transport of β-amyloid across the blood-brain barrier. Curr Pharm Des (2011) 0.85

The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors. Bioorg Med Chem Lett (2008) 0.83

Ovarian aging in squirrel monkeys (Saimiri sciureus). Reproduction (2009) 0.83

Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mech Ageing Dev (2004) 0.81

Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI. J Alzheimers Dis (2011) 0.80

Context dependence of protein misfolding and structural strains in neurodegenerative diseases. Biopolymers (2013) 0.80

The grandmother effect and the uniqueness of the human aging phenotype. Gerontology (2009) 0.79

A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain. J Neurochem (2014) 0.79

Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Epilepsia (2005) 0.78

Cerebral amyloid angiopathy in an aged sooty mangabey (Cercocebus atys). Comp Med (2013) 0.76

Xanthomatosis. J Neurosurg (2002) 0.75

The Malignant Protein Puzzle. Cerebrum (2016) 0.75