Published in J Neurotrauma on July 01, 2008
Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury. Nat Med (2016) 1.40
Inhibition of cysteine proteases in acute and chronic spinal cord injury. Neurotherapeutics (2011) 1.02
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Exp Neurol (2012) 0.91
A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model. J Neurotrauma (2010) 0.90
Administration of low dose estrogen attenuates persistent inflammation, promotes angiogenesis, and improves locomotor function following chronic spinal cord injury in rats. J Neurochem (2016) 0.89
Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. J Control Release (2015) 0.85
Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury. PLoS One (2012) 0.81
The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery. BMC Neurosci (2013) 0.81
A calpain inhibitor enhances the survival of Schwann cells in vitro and after transplantation into the injured spinal cord. J Neurotrauma (2010) 0.81
Recent advances in the pharmacologic treatment of spinal cord injury. Metab Brain Dis (2014) 0.79
Rescuing axons from degeneration does not affect retinal ganglion cell death. Braz J Med Biol Res (2016) 0.79
Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats. J Neurotrauma (2013) 0.77
CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury. Mol Neurobiol (2016) 0.75
Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats. Neurochem Res (2017) 0.75
Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol (1996) 5.46
Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J Neurotrauma (2003) 3.30
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell (2005) 2.63
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain. J Cell Biol (1998) 2.12
Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat. Exp Neurol (1999) 1.78
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene (2001) 1.59
Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience (1983) 1.48
Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection. J Neurosci Res (2005) 1.27
Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors. Brain Res Brain Res Rev (2003) 1.22
Cyclosporin A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing. J Neurotrauma (2001) 1.18
Developing selective inhibitors of calpain. Trends Pharmacol Sci (1990) 1.17
Selective release of a processed form of interleukin 1 alpha. Cytokine (1994) 1.11
The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. J Neurotrauma (2001) 1.09
Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury. J Neurochem (2000) 1.09
Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. J Neurochem (1997) 1.08
Calpain inhibitor I reduces the development of acute and chronic inflammation. Am J Pathol (2000) 1.05
Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury. Neurochem Res (2007) 1.04
Local blockade of sodium channels by tetrodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury. J Neurosci (1997) 0.98
Increased calpain I-mediated proteolysis, and preferential loss of dephosphorylated NF200, following traumatic spinal cord injury. Neuroscience (1999) 0.97
Cytoskeletal disruption following contusion injury to the rat spinal cord. J Neuropathol Exp Neurol (2000) 0.97
Mechanism of myelin breakdown in experimental demyelination: a putative role for calpain. Neurochem Res (2001) 0.97
Development and therapeutic potential of calpain inhibitors. Adv Pharmacol (1997) 0.94
Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent. Br J Pharmacol (2002) 0.92
Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury. Brain (2003) 0.92
Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury. Brain Res (1997) 0.92
Developments in the design and synthesis of calpain inhibitors. Curr Opin Drug Discov Devel (2005) 0.92
Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration. Neuroscience (2004) 0.92
Agmatine improves locomotor function and reduces tissue damage following spinal cord injury. Neuroreport (2000) 0.92
Beta1 integrin-mediated T cell adhesion and cell spreading are regulated by calpain. Exp Cell Res (2000) 0.90
Calpain activity and translational expression increased in spinal cord injury. Brain Res (1999) 0.89
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries. J Biol Chem (2007) 0.89
Calpain and calpastatin expression in primary oligodendrocyte culture: preferential localization of membrane calpain in cell processes. J Neurosci Res (2002) 0.89
Calpain activity and expression increased in activated glial and inflammatory cells in penumbra of spinal cord injury lesion. J Neurosci Res (2000) 0.88
New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro. J Neurosci Res (1998) 0.87
Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis. J Cereb Blood Flow Metab (2000) 0.86
Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma (2005) 0.86
Comparison of two methods for quantitative assessment of unrestrained locomotion in the rat. J Neurosci Methods (2007) 0.85
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. J Neuropathol Exp Neurol (2005) 0.84
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke (1995) 0.83
Proteolytic enzymes in experimental spinal cord injury. J Neurol Sci (1986) 0.83
Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection. J Neurotrauma (2003) 0.82
The calpain inhibitor VI prevents apoptosis of adult motor neurons. Neuroreport (2005) 0.81
A novel series of urea-based peptidomimetic calpain inhibitors. Bioorg Med Chem Lett (2006) 0.77
A role for calcium and activation of neutral proteinase in myelinolysis? Prog Clin Biol Res (1984) 0.77
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria. J Biol Chem (2006) 1.93
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition. J Neurosci (2007) 1.65
WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Curr Biol (2012) 1.55
Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria. J Neurosci Methods (2004) 1.27
Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. J Chem Neuroanat (2011) 1.10
Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium. J Bioenerg Biomembr (2004) 1.08
Mitochondrial localization of mu-calpain. Biochem Biophys Res Commun (2005) 1.05
Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury. Neurochem Res (2007) 1.04
N terminus of calpain 1 is a mitochondrial targeting sequence. J Biol Chem (2007) 1.03
A multi-mode shock tube for investigation of blast-induced traumatic brain injury. J Neurotrauma (2011) 1.02
Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor. Exp Neurol (2009) 0.97
Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury. J Neurotrauma (2002) 0.97
Calpain 1 and Calpastatin expression is developmentally regulated in rat brain. Exp Neurol (2009) 0.92
Nicotine attenuates morphological deficits in a contusion model of spinal cord injury. J Neurotrauma (2005) 0.90
Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid. Neurochem Int (2003) 0.89
Glutamate regulates caveolin expression in rat hippocampal neurons. J Neurosci Res (2003) 0.88
Involvement of ERK2 in traumatic spinal cord injury. J Neurochem (2010) 0.87
Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons. J Alzheimers Dis (2005) 0.86
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology. J Neuropathol Exp Neurol (2003) 0.85
Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model. J Neurochem (2013) 0.84
Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection. J Neurotrauma (2003) 0.82
Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma. Brain Res Mol Brain Res (2004) 0.82
Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde. J Neurosci Methods (2007) 0.80
Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model. Mol Neurobiol (2013) 0.80
Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release. Neuromolecular Med (2010) 0.79
Tat-calpastatin fusion proteins transduce primary rat cortical neurons but do not inhibit cellular calpain activity. Exp Neurol (2004) 0.78
Color changing photonic crystals detect blast exposure. Neuroimage (2010) 0.78
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity. Neurochem Res (2008) 0.78
Special Issue: Mitochondria and neurodegeneration. Exp Neurol (2009) 0.77
Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats. J Neurotrauma (2013) 0.77
3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease. Neurochem Res (2002) 0.76