Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 2706539)

Published in Mol Cells on July 23, 2008

Authors

Dmitri E Fomenko1, Stefano M Marino, Vadim N Gladyshev

Author Affiliations

1: Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588-0664, USA.

Articles citing this

Arsenic binding to proteins. Chem Rev (2013) 1.28

Oxidative stress, redox signaling, and autophagy: cell death versus survival. Antioxid Redox Signal (2014) 1.25

Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. PLoS Genet (2011) 1.13

Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal (2012) 1.11

Overview of peroxiredoxins in oxidant defense and redox regulation. Curr Protoc Toxicol (2011) 1.08

Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal (2011) 0.89

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity. Aging Dis (2016) 0.88

Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease. Antioxid Redox Signal (2012) 0.88

Protein redox modification as a cellular defense mechanism against tissue ischemic injury. Oxid Med Cell Longev (2014) 0.86

Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes. Antioxid Redox Signal (2011) 0.85

Comparative oxidation state specific analysis of arsenic species by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry and hydride generation-cryotrapping-atomic absorption spectrometry. J Anal At Spectrom (2013) 0.81

S-glutathionylation in monocyte and macrophage (dys)function. Int J Mol Sci (2013) 0.80

Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications. Biochem Insights (2016) 0.79

Cardiovascular redox and ox stress proteomics. Antioxid Redox Signal (2012) 0.79

Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis. World J Biol Chem (2015) 0.78

Escherichia coli thioredoxin-like protein YbbN contains an atypical tetratricopeptide repeat motif and is a negative regulator of GroEL. J Biol Chem (2011) 0.77

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. J Pharm Sci (2016) 0.75

Glutathione peroxidase 4: a new player in neurodegeneration? Mol Psychiatry (2016) 0.75

Transcriptomes of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Exposed to Metal "Shock" Reveal Generic and Specific Metal Responses. Appl Environ Microbiol (2016) 0.75

A PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3p. Nucleic Acids Res (2011) 0.75

Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features. BMC Bioinformatics (2016) 0.75

Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A. Protein Sci (2015) 0.75

Privileged Electrophile Sensors: A Resource for Covalent Drug Development. Cell Chem Biol (2017) 0.75

Articles cited by this

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol (1999) 33.07

STRING 7--recent developments in the integration and prediction of protein interactions. Nucleic Acids Res (2006) 12.16

PRINTS and its automatic supplement, prePRINTS. Nucleic Acids Res (2003) 10.01

Characterization of mammalian selenoproteomes. Science (2003) 9.07

Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem (1996) 8.08

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science (2003) 6.96

The 20 years of PROSITE. Nucleic Acids Res (2007) 6.06

ScanProsite: a reference implementation of a PROSITE scanning tool. Appl Bioinformatics (2002) 5.81

Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol (2004) 4.96

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60

How selenium has altered our understanding of the genetic code. Mol Cell Biol (2002) 4.52

Selenocysteine. Annu Rev Biochem (1996) 4.08

A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell (2002) 3.94

Thioredoxin--a fold for all reasons. Structure (1995) 3.85

Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE (2000) 3.45

Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem Sci (1991) 2.99

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87

Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A (2006) 2.58

S-glutathionylation in protein redox regulation. Free Radic Biol Med (2007) 2.53

Method for prediction of protein function from sequence using the sequence-to-structure-to-function paradigm with application to glutaredoxins/thioredoxins and T1 ribonucleases. J Mol Biol (1998) 2.44

Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol (2005) 2.28

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol (2008) 2.17

Prediction of disordered regions in proteins from position specific score matrices. Proteins (2003) 2.09

Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family. J Mol Biol (1995) 2.01

High-throughput identification of catalytic redox-active cysteine residues. Science (2007) 1.92

The CXXC motif: a rheostat in the active site. Biochemistry (1997) 1.90

MDB: the Metalloprotein Database and Browser at The Scripps Research Institute. Nucleic Acids Res (2002) 1.89

Oxidative protein folding in bacteria. Mol Microbiol (2002) 1.87

Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid Redox Signal (2008) 1.78

Sulfur and selenium: the role of oxidation state in protein structure and function. Angew Chem Int Ed Engl (2003) 1.77

The CXXC motif: imperatives for the formation of native disulfide bonds in the cell. EMBO J (1996) 1.74

Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol (2005) 1.72

The redox-switch domain of Hsp33 functions as dual stress sensor. Nat Struct Mol Biol (2007) 1.69

The genomics of disulfide bonding and protein stabilization in thermophiles. PLoS Biol (2005) 1.67

A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Mol Cell (2004) 1.65

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A (2008) 1.58

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid. Protein Sci (2008) 1.54

Redox switch of hsp33 has a novel zinc-binding motif. J Biol Chem (2000) 1.53

Metal and redox modulation of cysteine protein function. Chem Biol (2003) 1.52

An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Bioinformatics (2005) 1.50

Structural basis for redox regulation of Yap1 transcription factor localization. Nature (2004) 1.50

Functional analysis of the Escherichia coli genome using the sequence-to-structure-to-function paradigm: identification of proteins exhibiting the glutaredoxin/thioredoxin disulfide oxidoreductase activity. J Mol Biol (1998) 1.46

Selenium in chemistry and biochemistry in comparison to sulfur. Biol Chem (2007) 1.43

S-nitrosylation: NO-related redox signaling to protect against oxidative stress. Antioxid Redox Signal (2006) 1.43

Identity and functions of CxxC-derived motifs. Biochemistry (2003) 1.37

Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One (2008) 1.36

Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry (2006) 1.32

Structure-based active site profiles for genome analysis and functional family subclassification. J Mol Biol (2003) 1.30

Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling. Free Radic Biol Med (2003) 1.29

Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol (2008) 1.27

An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. J Neurosci Res (2007) 1.23

Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease. Antioxid Redox Signal (2006) 1.20

Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. J Neurosci (2007) 1.18

Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet (2008) 1.15

Prediction of reversibly oxidized protein cysteine thiols using protein structure properties. Protein Sci (2008) 1.12

Genomic-scale comparison of sequence- and structure-based methods of function prediction: does structure provide additional insight? Protein Sci (2001) 1.08

Molecular mechanism of thioredoxin regulation in photosynthetic A2B2-glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (2007) 1.03

Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme. Biochemistry (2004) 1.01

Prediction of pKa and redox properties in the thioredoxin superfamily. Protein Sci (2004) 1.00

CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Protein Sci (2002) 0.99

Identification of trace element-containing proteins in genomic databases. Annu Rev Nutr (2004) 0.95

The CXXC motif at the N terminus of an alpha-helical peptide. Protein Sci (2006) 0.89

Inactivation of glyceraldehyde 3-phosphate dehydrogenase by sugars, prednisolone-21-hemisuccinate, cyanate and other small molecules. Biochim Biophys Acta (1997) 0.85

The machinery for oxidative protein folding in thermophiles. Antioxid Redox Signal (2008) 0.83

Articles by these authors

The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science (2007) 11.15

Characterization of mammalian selenoproteomes. Science (2003) 9.07

How selenium has altered our understanding of the genetic code. Mol Cell Biol (2002) 4.52

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19

Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol (2007) 2.96

Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2002) 2.33

Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J (2002) 2.13

Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell (2003) 2.11

Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc Natl Acad Sci U S A (2004) 1.97

High-throughput identification of catalytic redox-active cysteine residues. Science (2007) 1.92

Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog Nucleic Acid Res Mol Biol (2006) 1.89

The prokaryotic selenoproteome. EMBO Rep (2004) 1.85

Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem (2006) 1.81

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress. Proc Natl Acad Sci U S A (2012) 1.80

Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics (2009) 1.80

Novel metabolism in Chlamydomonas through the lens of genomics. Curr Opin Plant Biol (2007) 1.77

MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell (2013) 1.77

Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J (2007) 1.76

Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A (2011) 1.76

Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol (2005) 1.72

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A (2004) 1.72

Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase. J Biol Chem (2002) 1.68

Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem (2003) 1.66

Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation. J Mol Biol (2009) 1.62

Eukaryotic selenoproteins and selenoproteomes. Biochim Biophys Acta (2009) 1.59

Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol Cell Biol (2002) 1.58

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep (2004) 1.58

Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues. Genome Biol (2006) 1.55

An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Bioinformatics (2005) 1.50

Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem (2004) 1.49

Pyrrolysine and selenocysteine use dissimilar decoding strategies. J Biol Chem (2005) 1.43

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life. Genome Biol (2007) 1.41

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol (2003) 1.41

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS One (2007) 1.40

Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene (2005) 1.39

The microbial selenoproteome of the Sargasso Sea. Genome Biol (2005) 1.39

A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc Natl Acad Sci U S A (2007) 1.38

Identity and functions of CxxC-derived motifs. Biochemistry (2003) 1.37

Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One (2008) 1.36

Hydrogen peroxide probes directed to different cellular compartments. PLoS One (2011) 1.34

Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J (2007) 1.34

Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res (2006) 1.32

Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry (2006) 1.32

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem (2007) 1.32

Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution. Biochemistry (2005) 1.32

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nat Commun (2013) 1.31

Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. J Biol Chem (2005) 1.31

SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry (2007) 1.31

Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. J Biol Chem (2006) 1.30

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life (2007) 1.30

General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se. J Biol Chem (2009) 1.29

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci U S A (2005) 1.29

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem (2005) 1.29

Analysis and functional prediction of reactive cysteine residues. J Biol Chem (2011) 1.29

Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry (2006) 1.28

Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol (2008) 1.27

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A (2011) 1.26

Structure and catalytic mechanism of eukaryotic selenocysteine synthase. J Biol Chem (2007) 1.26

Functions and evolution of selenoprotein methionine sulfoxide reductases. Biochim Biophys Acta (2009) 1.25

MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem (2008) 1.24

Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? Nucleic Acids Res (2005) 1.24

Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem (2005) 1.24

Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. J Mol Biol (2010) 1.24

Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. Proc Natl Acad Sci U S A (2005) 1.23

Evolution of selenium utilization traits. Genome Biol (2005) 1.22

Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol (2008) 1.22

Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem (2008) 1.22

The Plasmodium selenoproteome. Nucleic Acids Res (2006) 1.21

Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem (2008) 1.19

Genetic code supports targeted insertion of two amino acids by one codon. Science (2009) 1.19

Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A (2007) 1.18

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet (2010) 1.18

Selenoproteins that function in cancer prevention and promotion. Biochim Biophys Acta (2009) 1.16

The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv (2009) 1.16

Recode-2: new design, new search tools, and many more genes. Nucleic Acids Res (2009) 1.15

Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet (2008) 1.15

Selenocysteine in thiol/disulfide-like exchange reactions. Antioxid Redox Signal (2012) 1.13

Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry (2005) 1.13

Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry (2009) 1.12

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem (2007) 1.12

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J Biol Chem (2007) 1.11

Composition and evolution of the vertebrate and mammalian selenoproteomes. PLoS One (2012) 1.11

Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci (2008) 1.11

Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal (2012) 1.11

Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prev Res (Phila) (2010) 1.10

Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal (2010) 1.09

High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis. Nucleic Acids Res (2007) 1.09

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods (2011) 1.08

Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns (2003) 1.08

Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem (2008) 1.07

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem (2009) 1.05

Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem (2008) 1.04

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal (2011) 1.04

Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A (2009) 1.04

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Biochem J (2010) 1.03

Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem Biophys Res Commun (2004) 1.03

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol (2009) 1.03