Published in Bioorg Med Chem on July 24, 2008
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. J Biol Chem (2009) 1.10
Evolutionary relationships of microbial aromatic prenyltransferases. PLoS One (2011) 1.09
Catalytic mechanism of aromatic prenylation by NphB. Biochemistry (2012) 0.91
Identification of a bifunctional maize C- and O-glucosyltransferase. J Biol Chem (2013) 0.87
A new group of aromatic prenyltransferases in fungi, catalyzing a 2,7-dihydroxynaphthalene 3-dimethylallyl-transferase reaction. J Biol Chem (2010) 0.86
Structure-based engineering increased the catalytic turnover rate of a novel phenazine prenyltransferase. PLoS One (2012) 0.84
Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products. J Biol Chem (2010) 0.79
Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol (2016) 0.78
Regiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum. Sci Rep (2016) 0.78
Synthesis and in Vitro Antifungal Activity against Botrytis cinerea of Geranylated Phenols and Their Phenyl Acetate Derivatives. Int J Mol Sci (2015) 0.77
Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds. PLoS One (2015) 0.77
Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily. PLoS One (2013) 0.76
Role of substrate dynamics in protein prenylation reactions. Acc Chem Res (2014) 0.76
Assembling the Setaria italica L. Beauv. genome into nine chromosomes and insights into regions affecting growth and drought tolerance. Sci Rep (2016) 0.75
Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily. PLoS One (2017) 0.75
Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer's disease. J Nat Med (2017) 0.75
Biotransformation of menadione to its prenylated derivative MK-3 using recombinant Pichia pastoris. J Ind Microbiol Biotechnol (2017) 0.75
Biosynthetic studies on terpenoids produced by Streptomyces. J Antibiot (Tokyo) (2017) 0.75
Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature (2005) 2.15
The ABBA family of aromatic prenyltransferases: broadening natural product diversity. Cell Mol Life Sci (2008) 1.50
Prenylated flavonoids: pharmacology and biotechnology. Curr Med Chem (2005) 1.40
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Res (2005) 1.33
Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. Cell Mol Life Sci (2002) 1.28
A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS Lett (2007) 1.23
Isolation and structural elucidation of an antioxidative agent, naphterpin. J Antibiot (Tokyo) (1990) 1.09
Understanding the substrate selectivity and the product regioselectivity of Orf2-catalyzed aromatic prenylations. Biochemistry (2007) 0.99
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. Cell (2008) 5.55
The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep (2003) 3.71
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res (2002) 2.90
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell (2003) 2.69
An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chem Biol (2004) 2.64
Biosynthesis of plant volatiles: nature's diversity and ingenuity. Science (2006) 2.34
Structure-function-folding relationship in a WW domain. Proc Natl Acad Sci U S A (2006) 2.28
Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature (2005) 2.15
Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature (2011) 2.12
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol (2006) 2.02
Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proc Natl Acad Sci U S A (2006) 1.96
An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. Plant J (2003) 1.94
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem (2001) 1.94
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell (2002) 1.87
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol (2007) 1.85
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol (2008) 1.77
Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci (2007) 1.76
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell (2006) 1.71
Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. Plant Cell (2002) 1.67
Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. Plant Cell (2003) 1.56
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem (2004) 1.54
A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases. Anal Biochem (2004) 1.53
Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin. J Biol Chem (2002) 1.48
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc (2006) 1.48
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. J Biol Chem (2002) 1.46
Methylation of gibberellins by Arabidopsis GAMT1 and GAMT2. Plant Cell (2007) 1.43
Architectures, mechanisms and molecular evolution of natural product methyltransferases. Nat Prod Rep (2012) 1.43
Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proc Natl Acad Sci U S A (2006) 1.41
Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol (2007) 1.36
The rise of chemodiversity in plants. Science (2012) 1.35
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae. DNA Res (2010) 1.32
The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep (2014) 1.32
An enzyme-coupled colorimetric assay for S-adenosylmethionine-dependent methyltransferases. Anal Biochem (2004) 1.30
Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS Chem Biol (2011) 1.28
Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate. Angew Chem Int Ed Engl (2002) 1.28
New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. Proc Natl Acad Sci U S A (2008) 1.27
An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid. Arch Biochem Biophys (2005) 1.27
Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice. Plant Mol Biol (2007) 1.27
Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature (2012) 1.25
Prophylaxis of C5 palsy after cervical expansive laminoplasty by bilateral partial foraminotomy. Spine J (2004) 1.25
Evolving biosynthetic tangos negotiate mechanistic landscapes. Nat Chem Biol (2008) 1.24
Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Int Immunol (2007) 1.24
Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). Plant Cell (2010) 1.24
A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS Lett (2007) 1.23
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. J Bacteriol (2006) 1.22
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry (2007) 1.19
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases. Chem Biol (2009) 1.19
Divergent perspectives on GM food. Nat Biotechnol (2002) 1.19
Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. Plant Cell (2005) 1.17
Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol Bioeng (2007) 1.17
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat Chem Biol (2009) 1.17
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc Natl Acad Sci U S A (2002) 1.15
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiol (2005) 1.13
Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides. J Am Chem Soc (2015) 1.13
Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes. Plant Physiol (2009) 1.12
The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. Plant J (2008) 1.12
Enzymatic functions of wild tomato methylketone synthases 1 and 2. Plant Physiol (2010) 1.12
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. J Biochem (2002) 1.10
The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae. J Antibiot (Tokyo) (2010) 1.10
Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. Plant Cell (2010) 1.09
Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. Proc Natl Acad Sci U S A (2013) 1.09
Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem (2001) 1.09
Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J Ind Microbiol Biotechnol (2003) 1.07
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway. Proc Natl Acad Sci U S A (2010) 1.06
Convergent strategies in biosynthesis. Nat Prod Rep (2011) 1.06
A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol (2003) 1.05
Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. PLoS Biol (2005) 1.05
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol (2006) 1.04
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J Biol Chem (2002) 1.04
Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice. FEBS Lett (2004) 1.04
Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Biochemistry (2004) 1.04
Cyclic GMP-gated CNG channels function in Sema3A-induced growth cone repulsion. Neuron (2008) 1.04
Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry (2002) 1.03
Characterization of bacterial homocitrate synthase involved in lysine biosynthesis. FEBS Lett (2002) 1.03
Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Nat Chem Biol (2013) 1.03
Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant Physiol (2004) 1.02
Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. Phytochemistry (2005) 1.02
Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. ACS Chem Biol (2012) 1.01
FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Blood (2006) 1.01
Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J Biol Chem (2004) 1.01
Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.01
Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase. J Biol Chem (2002) 1.00
Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells (2011) 0.99
Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. Biochim Biophys Acta (2005) 0.99
Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. J Biol Chem (2003) 0.98
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98
fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. FEBS Lett (2005) 0.98
Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. ACS Chem Biol (2010) 0.98
Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem (2007) 0.98
Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. Appl Microbiol Biotechnol (2008) 0.97