Published in Nat Chem Biol on September 01, 2008
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol (2013) 1.71
The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors. Br J Pharmacol (2013) 1.70
The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology (2012) 1.53
Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opin Ther Targets (2011) 1.16
Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J (2010) 1.14
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene (2011) 1.10
Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii. Mar Drugs (2012) 1.10
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation (2009) 1.07
NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest (2012) 1.04
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Mol Endocrinol (2013) 1.04
Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochem Pharmacol (2012) 1.03
The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol Cancer Res (2014) 1.01
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Mol Endocrinol (2014) 0.99
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis (2011) 0.97
Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97
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Structural and functional insights into nuclear receptor signaling. Adv Drug Deliv Rev (2010) 0.89
TR3 modulates platinum resistance in ovarian cancer. Cancer Res (2013) 0.88
Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother (2013) 0.88
Nuclear receptor 4A (NR4A) family - orphans no more. J Steroid Biochem Mol Biol (2015) 0.86
Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene (2011) 0.86
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One (2015) 0.86
Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. J Am Chem Soc (2011) 0.82
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer. Cell Signal (2014) 0.82
Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol (2014) 0.82
Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer. BMC Cancer (2013) 0.81
A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Res (2008) 0.81
NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation. Oncotarget (2015) 0.81
Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress. Sci Rep (2016) 0.80
Nurr1-Based Therapies for Parkinson's Disease. CNS Neurosci Ther (2016) 0.80
The orphan nuclear receptors at their 25-year reunion. J Mol Endocrinol (2013) 0.80
NR4A Orphan Nuclear Receptors in Cardiovascular Biology. Drug Discov Today Dis Mech (2009) 0.80
Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression. Br J Pharmacol (2015) 0.80
Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK. Carcinogenesis (2014) 0.79
Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells. J Mol Cell Cardiol (2014) 0.78
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem (2009) 0.77
A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage. BMC Cancer (2015) 0.76
High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol (2016) 0.76
Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1. ACS Chem Biol (2016) 0.76
Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget (2016) 0.76
Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells. Tumour Biol (2015) 0.75
PAX3-FOXO1A expression in rhabdomyosarcoma is driven by the targetable nuclear receptor NR4A1. Cancer Res (2016) 0.75
Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner. Neuropsychopharmacology (2016) 0.75
Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis. Oncotarget (2015) 0.75
Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability. Medchemcomm (2013) 0.75
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nat Commun (2017) 0.75
NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells. Front Immunol (2017) 0.75
Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors. FASEB J (2015) 0.75
Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer. Front Endocrinol (Lausanne) (2015) 0.75
In Silico Adoption of an Orphan Nuclear Receptor NR4A1. PLoS One (2015) 0.75
NR4A1 is an endogenous inhibitor of vocal fold fibrosis. Laryngoscope (2017) 0.75
TGFβ/NR4A1 Inducible Breast Cancer Cell Migration and Epithelial to Mesenchymal Transition is p38α (MAPK14) Dependent. Mol Cell Biol (2017) 0.75
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Oncotarget (2017) 0.75
Dnmt3a regulates T-cell development and suppresses T-ALL transformation. Leukemia (2017) 0.75
The Nuclear Orphan Receptor NR4A1 Regulates β1-Integrin Expression in Pancreatic and Colon Cancer Cells and Can Be Targeted by NR4A1 Antagonists. Mol Carcinog (2017) 0.75
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature (2013) 4.43
Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum (2003) 3.73
Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet (2003) 3.71
Enhanced sulfur and coking tolerance of a mixed ion conductor for SOFCs: BaZr(0.1)Ce(0.7)Y(0.2-x)Yb(x)O(3-delta). Science (2009) 2.36
Meta-analysis: eradication of Helicobacter pylori infection is associated with the development of endoscopic gastroesophageal reflux disease. Eur J Gastroenterol Hepatol (2013) 2.17
Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery. Adv Mater (2012) 2.15
Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci U S A (2009) 1.92
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation (2009) 1.91
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. Biomaterials (2009) 1.82
Retracted Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications. Part Fibre Toxicol (2013) 1.80
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways. Cell Host Microbe (2011) 1.77
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano (2011) 1.65
Lamellar keratoplasty for the treatment of fungal keratitis. Cornea (2002) 1.65
Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res (2010) 1.64
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway. Nat Commun (2012) 1.62
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann Thorac Surg (2010) 1.57
Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure. Cardiovasc Res (2009) 1.57
Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice. Biomaterials (2010) 1.54
Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology (2011) 1.54
Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. J Biomed Mater Res A (2013) 1.52
Discontinuation of antithrombotic therapy for a year or more in patients with continuous-flow left ventricular assist devices. Interact Cardiovasc Thorac Surg (2010) 1.51
Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice. Chemosphere (2013) 1.51
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS One (2013) 1.46
Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. J Am Chem Soc (2010) 1.46
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes (2009) 1.45
Axin: a master scaffold for multiple signaling pathways. Neurosignals (2004) 1.45
A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44
Bioactive natural products from Lysobacter. Nat Prod Rep (2012) 1.42
Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab (2012) 1.41
Increase in serum pregnancy-associated plasma protein-A is correlated with increase in cardiovascular risk factors in adult patients with growth hormone deficiency. Endocrine (2012) 1.41
Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis. BMC Cancer (2014) 1.38
Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther (2011) 1.37
Random lasing in bone tissue. Opt Lett (2010) 1.37
Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core. Biochim Biophys Acta (2011) 1.36
Increased blood-brain barrier permeability is not a primary determinant for lethality of West Nile virus infection in rodents. J Gen Virol (2008) 1.33
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology (2012) 1.32
p53 mediates the negative regulation of MDM2 by orphan receptor TR3. EMBO J (2006) 1.30
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs. Breast Cancer Res (2013) 1.29
Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221. J Biol Chem (2012) 1.28
Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11. Antimicrob Agents Chemother (2011) 1.27
Retracted Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling. Lab Invest (2011) 1.26
Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte. J Neurosci (2011) 1.26
Complete Genome Sequences of a Clinical Isolate and an Environmental Isolate of Vibrio parahaemolyticus. Genome Announc (2015) 1.25
In vivo delivery of silica nanorattle encapsulated docetaxel for liver cancer therapy with low toxicity and high efficacy. ACS Nano (2010) 1.25
Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. Clin Exp Metastasis (2007) 1.24
Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. J Biol Chem (2011) 1.23
Retracted RNA interference targeting slug increases cholangiocarcinoma cell sensitivity to cisplatin via upregulating PUMA. Int J Mol Sci (2011) 1.22
A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride. Invest Ophthalmol Vis Sci (2008) 1.21
Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma. Proc Natl Acad Sci U S A (2010) 1.20
Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. Angew Chem Int Ed Engl (2010) 1.20
Dielectrophoretic separation of platelets from diluted whole blood in microfluidic channels. Electrophoresis (2008) 1.20
SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem (2002) 1.20
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev Cell (2006) 1.19
The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes. Biomaterials (2013) 1.18
TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis. Cancer Res (2007) 1.18
PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv Mater (2013) 1.17
ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS (2010) 1.17
The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev Cell (2009) 1.17
Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenström's macroglobulinemia. Mod Pathol (2009) 1.17
Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol Biol Cell (2005) 1.17
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem (2004) 1.16
A putative CCAAT-binding transcription factor is a regulator of flowering timing in Arabidopsis. Plant Physiol (2007) 1.15
Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events. J Biol Chem (2004) 1.15
Biodegradation of fenvalerate and 3-phenoxybenzoic acid by a novel Stenotrophomonas sp. strain ZS-S-01 and its use in bioremediation of contaminated soils. Appl Microbiol Biotechnol (2010) 1.15
Virus-like particle-based human vaccines: quality assessment based on structural and functional properties. Trends Biotechnol (2013) 1.14
Retracted Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity. Microbiology (2005) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Nod1-dependent control of tumor growth. Proc Natl Acad Sci U S A (2006) 1.13
Demonstration of Al:ZnO as a plasmonic component for near-infrared metamaterials. Proc Natl Acad Sci U S A (2012) 1.13
Aromatase, breast cancer and obesity: a complex interaction. Trends Endocrinol Metab (2011) 1.12
Silica nanorattle-doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy. ACS Nano (2011) 1.12
Optimization of Applications with Non-blocking Neighborhood Collectives via Multisends on the Blue Gene/P Supercomputer. IPDPS (2010) 1.11
Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A (2011) 1.11
Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol (2007) 1.10
A platform of high-density INDEL/CAPS markers for map-based cloning in Arabidopsis. Plant J (2010) 1.09
Organization of the polarization splay modulated smectic liquid crystal phase by topographic confinement. Proc Natl Acad Sci U S A (2010) 1.08
Identification of the leucine-to-2-methylbutyric acid catabolic pathway of Lactococcus lactis. Appl Environ Microbiol (2006) 1.08
Outcomes of liver resection for intrahepatic stones: a comparative study of unilateral versus bilateral disease. Ann Surg (2012) 1.08