Published in J Neurochem on August 07, 2008
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc Natl Acad Sci U S A (2010) 2.48
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry (2010) 1.63
Anti-prion activity of Brilliant Blue G. PLoS One (2012) 1.48
Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry (2012) 1.13
Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers. Protein Sci (2012) 1.05
Emergence and natural selection of drug-resistant prions. Mol Biosyst (2010) 1.05
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem (2013) 1.01
Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev (2013) 0.98
Chemical induction of misfolded prion protein conformers in cell culture. J Biol Chem (2009) 0.97
Natural compounds may open new routes to treatment of amyloid diseases. Neurotherapeutics (2013) 0.92
Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones. Protein Sci (2012) 0.86
EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells. Oncotarget (2015) 0.85
Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor. PLoS One (2012) 0.84
Countering amyloid polymorphism and drug resistance with minimal drug cocktails. Prion (2010) 0.83
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios. FEBS Lett (2014) 0.80
The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD). BMC Med Genet (2011) 0.78
Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives. PeerJ (2015) 0.75
Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia. Prion (2015) 0.75
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
Casting metal nanowires within discrete self-assembled peptide nanotubes. Science (2003) 3.59
Large-scale identification of N-terminal peptides in the halophilic archaea Halobacterium salinarum and Natronomonas pharaonis. J Proteome Res (2007) 3.30
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol (2008) 3.27
Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism. Chem Biol Drug Des (2006) 3.04
Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex. Nature (2002) 2.65
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
The genome of the square archaeon Haloquadratum walsbyi : life at the limits of water activity. BMC Genomics (2006) 2.48
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis. Genome Res (2005) 2.22
Controlled patterning of aligned self-assembled peptide nanotubes. Nat Nanotechnol (2006) 2.14
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell (2013) 2.12
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12
Discovery of two novel families of proteins that are proposed to interact with prokaryotic SMC proteins, and characterization of the Bacillus subtilis family members ScpA and ScpB. Mol Microbiol (2002) 2.06
Development of the signal in sensory rhodopsin and its transfer to the cognate transducer. Nature (2006) 1.83
Proteorhodopsin is a light-driven proton pump with variable vectoriality. J Mol Biol (2002) 1.81
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80
Metabolism of halophilic archaea. Extremophiles (2008) 1.75
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T. Environ Microbiol (2010) 1.70
Amyloids: not only pathological agents but also ordered nanomaterials. Angew Chem Int Ed Engl (2008) 1.66
Mechanical and structural properties of YOYO-1 complexed DNA. Nucleic Acids Res (2010) 1.66
Amyloid fibril formation by pentapeptide and tetrapeptide fragments of human calcitonin. J Biol Chem (2002) 1.66
Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity. Cell (2010) 1.65
Absolute SILAC for accurate quantitation of proteins in complex mixtures down to the attomole level. J Proteome Res (2008) 1.64
Stability of bacteriorhodopsin alpha-helices and loops analyzed by single-molecule force spectroscopy. Biophys J (2002) 1.60
Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions. Biochemistry (2004) 1.60
Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J Biol Chem (2006) 1.59
Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules. Nucleic Acids Res (2007) 1.58
Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol (2010) 1.58
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
The YefM antitoxin defines a family of natively unfolded proteins: implications as a novel antibacterial target. J Biol Chem (2003) 1.56
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J Neurosci (2007) 1.54
Secondary structure, dynamics, and topology of a seven-helix receptor in native membranes, studied by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2007) 1.54
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I. EMBO J (2006) 1.51
Transducer binding establishes localized interactions to tune sensory rhodopsin II. Structure (2008) 1.50
Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy. J Neurochem (2009) 1.50
Torsional stiffness of single superparamagnetic microspheres in an external magnetic field. Phys Rev Lett (2009) 1.46
Autophagy induction by trehalose counteracts cellular prion infection. Autophagy (2009) 1.46
Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder. Proc Natl Acad Sci U S A (2005) 1.43
Peptide-based hydrogel nanoparticles as effective drug delivery agents. Bioorg Med Chem (2013) 1.42
Highly efficient and chemoselective peptide ubiquitylation. Angew Chem Int Ed Engl (2009) 1.42
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures. Nano Lett (2005) 1.38
Type III restriction enzymes communicate in 1D without looping between their target sites. Proc Natl Acad Sci U S A (2009) 1.38
Pathogenic mutations inactivate parkin by distinct mechanisms. J Neurochem (2005) 1.38
Haloquadratum walsbyi: limited diversity in a global pond. PLoS One (2011) 1.37
Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins. Angew Chem Int Ed Engl (2011) 1.36
Fast dynamics of supercoiled DNA revealed by single-molecule experiments. Proc Natl Acad Sci U S A (2007) 1.35
The human islet amyloid polypeptide forms transient membrane-active prefibrillar assemblies. Biochemistry (2003) 1.30
Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons. FASEB J (2005) 1.29
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29
Energetics at the DNA supercoiling transition. Biophys J (2010) 1.29
Formation of critical oligomers is a key event during conformational transition of recombinant syrian hamster prion protein. J Biol Chem (2003) 1.29
Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J Biol Chem (2003) 1.27
Unfolding pathways of native bacteriorhodopsin depend on temperature. EMBO J (2003) 1.27
Genome information management and integrated data analysis with HaloLex. Arch Microbiol (2008) 1.26
Strong piezoelectricity in bioinspired peptide nanotubes. ACS Nano (2010) 1.25
Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell (2006) 1.25
Reconstruction, modeling & analysis of Halobacterium salinarum R-1 metabolism. Mol Biosyst (2007) 1.25
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J (2003) 1.25
Gene expression profiling of scrapie-infected brain tissue. Biochem Biophys Res Commun (2004) 1.24
In vivo aggregation of a single enzyme limits growth of Escherichia coli at elevated temperatures. Mol Microbiol (2002) 1.22
Novel electrochemical biosensing platform using self-assembled peptide nanotubes. Nano Lett (2005) 1.22
Identification and characterization of a novel molecular-recognition and self-assembly domain within the islet amyloid polypeptide. J Mol Biol (2002) 1.21
Self-assembled arrays of peptide nanotubes by vapour deposition. Nat Nanotechnol (2009) 1.20
Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries. Crit Care (2013) 1.19
Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J (2008) 1.18
Functional cell-free synthesis of a seven helix membrane protein: in situ insertion of bacteriorhodopsin into liposomes. J Mol Biol (2007) 1.18
Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin. Angew Chem Int Ed Engl (2006) 1.17
Direct mechanical measurements reveal the material properties of three-dimensional DNA origami. Nano Lett (2011) 1.16
Conformational adaptability of Redbeta during DNA annealing and implications for its structural relationship with Rad52. J Mol Biol (2009) 1.16
DNA-DNA interactions in tight supercoils are described by a small effective charge density. Phys Rev Lett (2010) 1.16
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci (2012) 1.15
Role of interleukin-1 in prion disease-associated astrocyte activation. Am J Pathol (2004) 1.13
Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease. Acta Neuropathol (2011) 1.13
The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation. J Bacteriol (2006) 1.12
Falciparum malaria after splenectomy: a prospective controlled study of 33 previously splenectomized Malawian adults. Trans R Soc Trop Med Hyg (2005) 1.11
Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy. J Mol Biol (2011) 1.11
Iron-oxo clusters biomineralizing on protein surfaces: structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states. Proc Natl Acad Sci U S A (2004) 1.11
Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid. Angew Chem Int Ed Engl (2004) 1.10
Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life. PLoS One (2009) 1.10
The archaeal sensory rhodopsin II/transducer complex: a model for transmembrane signal transfer. FEBS Lett (2004) 1.09
The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA. Science (2013) 1.09
Structural analysis of a HAMP domain: the linker region of the phototransducer in complex with sensory rhodopsin II. J Biol Chem (2005) 1.09