Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin.
|
Chem Biol
|
2004
|
1.59
|
2
|
The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.
|
Proc Natl Acad Sci U S A
|
2008
|
1.10
|
3
|
Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue.
|
Org Lett
|
2010
|
1.10
|
4
|
Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implications for biological activity.
|
Org Biomol Chem
|
2009
|
0.94
|
5
|
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.
|
Proc Natl Acad Sci U S A
|
2006
|
0.94
|
6
|
Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.
|
Toxicol Lett
|
2010
|
0.92
|
7
|
Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof.
|
Bioorg Med Chem
|
2009
|
0.89
|
8
|
Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.
|
FEBS Lett
|
2005
|
0.87
|
9
|
Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D.
|
J Am Chem Soc
|
2003
|
0.85
|
10
|
Synthetic studies on daphnicyclidin A: enantiocontrolled construction of the BCD ring system.
|
Org Lett
|
2009
|
0.84
|
11
|
Total synthesis of methyl sarcophytoate, a marine natural biscembranoid.
|
J Org Chem
|
2009
|
0.84
|
12
|
Synthesis and biological activities of reveromycin A and spirofungin A derivatives.
|
Bioorg Med Chem Lett
|
2008
|
0.83
|
13
|
Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-beta-lactam core of chartellines.
|
Chem Commun (Camb)
|
2009
|
0.82
|
14
|
Total synthesis and determination of the absolute configuration of (-)-idesolide.
|
Org Lett
|
2010
|
0.81
|
15
|
An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R.
|
J Org Chem
|
2009
|
0.80
|
16
|
Detection of cytochrome P450 substrates by using a small-molecule droplet array on an NADH-immobilized solid surface.
|
Chembiochem
|
2011
|
0.79
|
17
|
Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells.
|
Biol Pharm Bull
|
2015
|
0.79
|
18
|
Studies aimed at the total synthesis of azadirachtin. A modeled connection of C-8 and C-14 in azadirachtin.
|
Org Lett
|
2002
|
0.78
|
19
|
Total synthesis of methyl sarcophytoate.
|
J Am Chem Soc
|
2007
|
0.78
|
20
|
Preparation of photo-cross-linked small molecule affinity matrices for affinity selection of protein targets for biologically active small molecules.
|
Methods Mol Biol
|
2012
|
0.78
|
21
|
Concise entry to both enantiomers of 8-oxabicyclo[3.2.1]oct-3-en-2-one based on novel oxidative etherification: formal synthesis of (+)-sundiversifolide.
|
Org Lett
|
2011
|
0.77
|
22
|
Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.
|
Chembiochem
|
2009
|
0.77
|
23
|
Eu(OTf)3-catalyzed highly regioselective nucleophilic ring opening of 2,3-epoxy alcohols: an efficient entry to 3-substituted 1,2-diol derivatives.
|
Org Lett
|
2014
|
0.77
|
24
|
Synthesis and structure-activity relationship of vicenistatin, a cytotoxic 20-membered macrolactam glycoside.
|
Chem Asian J
|
2012
|
0.75
|
25
|
Reversibility of the thia-Michael reaction of cytotoxic C5-curcuminoid and structure-activity relationship of bis-thiol-adducts thereof.
|
Org Biomol Chem
|
2016
|
0.75
|
26
|
Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.
|
Nucleic Acids Symp Ser (Oxf)
|
2007
|
0.75
|
27
|
An improved fluorogenic NAD(P)+ detection method using 2-acetylbenzofuran: its origin and application.
|
Chem Commun (Camb)
|
2013
|
0.75
|
28
|
Concise, Protecting-Group-Free Synthesis of (+)-Nemonapride via Eu(OTf)3-Catalyzed Aminolysis of 3,4-Epoxy Alcohol.
|
Chem Pharm Bull (Tokyo)
|
2017
|
0.75
|
29
|
Substrate recognition by a dual functional P450 monooxygenase GfsF involved in FD-891 biosynthesis.
|
Chembiochem
|
2017
|
0.75
|