The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 3151559)

Published in Addict Biol on August 19, 2008

Authors

Lara A Ray1, Angela Bryan, James Mackillop, John McGeary, Kirstin Hesterberg, Kent E Hutchison

Author Affiliations

1: Brown University, Center for Alcohol and Addiction Studies, USA. Lara_Ray@Brown.edu

Articles citing this

The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review. Pharmacol Biochem Behav (2009) 1.45

Associations between dopamine D4 receptor gene variation with both infidelity and sexual promiscuity. PLoS One (2010) 1.20

Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis. J Fam Psychol (2010) 1.19

Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample. Addict Biol (2009) 1.19

Genetically influenced change in sensation seeking drives the rise of delinquent behavior during adolescence. Dev Sci (2011) 1.07

Pharmacogenetics of alcohol and alcohol dependence treatment. Curr Pharm Des (2010) 1.05

Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neurosci Biobehav Rev (2011) 1.00

Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. J Neurosci (2013) 0.95

Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects. J Child Psychol Psychiatry (2013) 0.93

Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation. Pharmacogenomics J (2010) 0.92

A human laboratory pilot study with baclofen in alcoholic individuals. Pharmacol Biochem Behav (2012) 0.91

Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem (2011) 0.90

Genetics of dopamine receptors and drug addiction. Hum Genet (2012) 0.89

Ghrelin influences novelty seeking behavior in rodents and men. PLoS One (2012) 0.85

Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. PLoS One (2011) 0.83

Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. J Abnorm Child Psychol (2011) 0.83

Perceived parental rejection mediates the influence of serotonin transporter gene (5-HTTLPR) polymorphisms on impulsivity in Japanese adults. PLoS One (2012) 0.79

DRD4 long allele carriers show heightened attention to high-priority items relative to low-priority items. J Cogn Neurosci (2014) 0.77

Novelty Seeking as a Phenotypic Marker of Adolescent Substance Use. Subst Abuse (2015) 0.77

Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: exploratory findings. Alcohol (2014) 0.76

The interaction between the dopamine receptor D4 (DRD4) variable number tandem repeat polymorphism and perceived peer drinking norms in adolescent alcohol use and misuse. Dev Psychopathol (2016) 0.76

Dopamine receptor gene d4 polymorphisms and early sexual onset: gender and environmental moderation in a sample of african-american youth. J Adolesc Health (2014) 0.75

Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study. J Stud Alcohol Drugs (2017) 0.75

Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward. Psychopharmacology (Berl) (2016) 0.75

Articles cited by this

The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry (2003) 21.70

Towards the assessment of adolescent problem drinking. J Stud Alcohol (1989) 14.10

Health and behavioral consequences of binge drinking in college. A national survey of students at 140 campuses. JAMA (1994) 12.32

A psychobiological model of temperament and character. Arch Gen Psychiatry (1993) 10.95

Simple non-invasive method to obtain DNA for gene analysis. Lancet (1988) 4.96

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature (1991) 4.36

Multiple dopamine D4 receptor variants in the human population. Nature (1992) 4.08

A review of research on the Alcohol Use Disorders Identification Test (AUDIT). Alcohol Clin Exp Res (1997) 3.62

Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem (1995) 3.08

DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behav Genet (1997) 2.64

Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci U S A (2001) 2.48

A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res (2004) 2.25

Collection of genomic DNA by buccal swabs for polymerase chain reaction-based biomarker assays. Environ Health Perspect (1999) 2.21

A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet (1993) 2.09

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell (1997) 1.83

Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data. Biol Psychiatry (2007) 1.72

Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci (1999) 1.69

The dopamine D(4) receptor: one decade of research. Eur J Pharmacol (2000) 1.69

Genetics of alcohol and tobacco use in humans. Ann Med (2003) 1.62

Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis. Behav Genet (1996) 1.49

A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry (2002) 1.44

Prevalence of alcohol-use disorders and alcohol-related problems in a college student sample. J Am Coll Health (1999) 1.36

The effect of olanzapine on craving and alcohol consumption. Neuropsychopharmacology (2006) 1.34

DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues. Psychopharmacology (Berl) (2007) 1.34

Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry (2000) 1.30

Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology (2003) 1.29

Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample. Biol Psychiatry (2006) 1.27

The DRD4 VNTR polymorphism moderates craving after alcohol consumption. Health Psychol (2002) 1.26

Genetic moderators of naltrexone's effects on alcohol cue reactivity. Alcohol Clin Exp Res (2006) 1.24

High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Mol Psychiatry (2003) 1.24

Alcoholism: the dissection for endophenotypes. Dialogues Clin Neurosci (2005) 1.16

Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol (1994) 1.14

Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience (2005) 1.13

Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study. Behav Brain Funct (2007) 1.11

A developmental behavior-genetic perspective on alcoholism risk. Alcohol Health Res World (1998) 1.07

Association of the DRD4 exon III polymorphism with smoking in fifteen-year-olds: a mediating role for novelty seeking? J Am Acad Child Adolesc Psychiatry (2005) 1.07

Dopamine D4 receptor-deficient mice display cortical hyperexcitability. J Neurosci (2001) 1.06

Cortical localization of dopamine D4 receptors in the rat brain--immunocytochemical study. J Physiol Pharmacol (2000) 1.04

Associations between smoking and heritable temperament traits. Nicotine Tob Res (2003) 0.99

Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. Eur J Neurosci (2005) 0.98

Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure. Addict Biol (2007) 0.96

The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. Ann Clin Psychiatry (2006) 0.95

Presynaptic dopamine D(4) receptor localization in the rat nucleus accumbens shell. Synapse (2000) 0.91

Investigating age differences in the genetic and environmental structure of the tridimensional personality questionnaire in later adulthood. Behav Genet (2003) 0.89

Personality dimensions and substance misuse: relationships in adolescents, mothers and fathers. Am J Addict (1999) 0.85

Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life Sci (2001) 0.81

D4 dopamine and metabotropic glutamate receptors in cerebral cortex and striatum in rat brain. Neurochem Res (2001) 0.80

Articles by these authors

Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc Natl Acad Sci U S A (2007) 3.33

Population stratification in the candidate gene study: fatal threat or red herring? Psychol Bull (2004) 2.81

Clinician-delivered intervention during routine clinical care reduces unprotected sexual behavior among HIV-infected patients. J Acquir Immune Defic Syndr (2006) 2.72

Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. Arch Gen Psychiatry (2007) 2.28

A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res (2004) 2.25

Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci (2009) 2.05

An information-motivation-behavioral skills (IMB) model-based HIV prevention intervention for truck drivers in India. Soc Sci Med (2007) 1.99

Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav Brain Funct (2007) 1.83

Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry. Neuropsychopharmacology (2007) 1.76

Relationships Between Future Orientation, Impulsive Sensation Seeking, and Risk Behavior Among Adjudicated Adolescents. J Adolesc Res (2004) 1.67

Marijuana craving in the brain. Proc Natl Acad Sci U S A (2009) 1.62

Dopaminergic genes predict individual differences in susceptibility to confirmation bias. J Neurosci (2011) 1.58

Effects of topiramate on urge to drink and the subjective effects of alcohol: a preliminary laboratory study. Alcohol Clin Exp Res (2008) 1.51

Children's attentional biases and 5-HTTLPR genotype: potential mechanisms linking mother and child depression. J Clin Child Adolesc Psychol (2009) 1.49

The DRD4 VNTR polymorphism influences reactivity to smoking cues. J Abnorm Psychol (2002) 1.48

Delay discounting, locus of control, and cognitive impulsiveness independently predict tobacco dependence treatment outcomes in a highly dependent, lower socioeconomic group of smokers. Am J Addict (2012) 1.45

CHRNA4 and tobacco dependence: from gene regulation to treatment outcome. Arch Gen Psychiatry (2007) 1.44

A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise. Health Psychol (2007) 1.43

P-selectin 1087G/A polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease. Stroke (2009) 1.43

Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. Alcohol Clin Exp Res (2008) 1.43

Identifying neurobiological phenotypes associated with alcohol use disorder severity. Neuropsychopharmacology (2011) 1.41

Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Subst Use Misuse (2010) 1.39

DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues. Psychopharmacology (Berl) (2007) 1.34

Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology (2003) 1.29

Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. Alcohol Clin Exp Res (2009) 1.28

The DRD4 VNTR polymorphism moderates craving after alcohol consumption. Health Psychol (2002) 1.26

In-task and post-task affective response to exercise: translating exercise intentions into behaviour. Br J Health Psychol (2009) 1.25

Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample. Addict Biol (2009) 1.19

Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology (2009) 1.19

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study. Brain Imaging Behav (2007) 1.17

Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction (2008) 1.13

Living in the here and now: interrelationships between impulsivity, mindfulness, and alcohol misuse. Psychopharmacology (Berl) (2011) 1.13

Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology (2012) 1.13

Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS One (2007) 1.09

The alcohol hangover research group consensus statement on best practice in alcohol hangover research. Curr Drug Abuse Rev (2010) 1.09

High-dose transdermal nicotine and naltrexone: effects on nicotine withdrawal, urges, smoking, and effects of smoking. Exp Clin Psychopharmacol (2007) 1.07

How psychosocial alcohol interventions work: a preliminary look at what FMRI can tell us. Alcohol Clin Exp Res (2011) 1.05

Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana. Exp Clin Psychopharmacol (2009) 1.05

Neural and behavioral mechanisms of impulsive choice in alcohol use disorder. Alcohol Clin Exp Res (2011) 1.04

Rare copy number deletions predict individual variation in intelligence. PLoS One (2011) 1.04

Tobacco and alcohol use as an explanation for the association between externalizing behavior and illicit drug use among delinquent adolescents. Prev Sci (2004) 1.03

What makes group MET work? A randomized controlled trial of college student drinkers in mandated alcohol diversion. Psychol Addict Behav (2009) 1.03

The relationship between measures of impulsivity and alcohol misuse: an integrative structural equation modeling approach. Alcohol Clin Exp Res (2011) 1.03

Association between nicotine dependence severity, BOLD response to smoking cues, and functional connectivity. Neuropsychopharmacology (2013) 1.02

Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression. J Affect Disord (2008) 1.02

Neural mechanisms of risk taking and relationships with hazardous drinking. Alcohol Clin Exp Res (2012) 1.01

The Big Picture of Individual Differences in Physical Activity Behavior Change: A Transdisciplinary Approach. Psychol Sport Exerc (2011) 1.01

Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol Clin Exp Res (2009) 1.00

Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression. J Abnorm Psychol (2009) 1.00

Integrating brain and behavior: evaluating adolescents' response to a cannabis intervention. Psychol Addict Behav (2012) 1.00

Risk factors for alcohol misuse: examining heart rate reactivity to alcohol, alcohol sensitivity, and personality constructs. Addict Behav (2006) 1.00

Associations among GABRG1, level of response to alcohol, and drinking behaviors. Alcohol Clin Exp Res (2009) 0.98

A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. Exp Clin Psychopharmacol (2009) 0.98

Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study. Psychopharmacology (Berl) (2007) 0.98

Consilient research approaches in studying gene x environment interactions in alcohol research. Addict Biol (2010) 0.96

Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure. Addict Biol (2007) 0.96

Proposed model of the neurobiological mechanisms underlying psychosocial alcohol interventions: the example of motivational interviewing. J Stud Alcohol Drugs (2011) 0.95

Application of human laboratory models to pharmacotherapy development for alcohol dependence. Curr Pharm Des (2010) 0.93

The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies. J Stud Alcohol Drugs (2007) 0.92

Isolating behavioural economic indices of demand in relation to nicotine dependence. Psychopharmacology (Berl) (2012) 0.92

Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology (Berl) (2008) 0.92

Motivational enhancement therapy for high-risk adolescent smokers. Addict Behav (2007) 0.91

Hair pulling disorder (trichotillomania): genes, neurobiology, and a model for understanding impulsivity and compulsivity. Psychiatry Res (2012) 0.91

Reduced executive and default network functional connectivity in cigarette smokers. Hum Brain Mapp (2014) 0.90

Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents. Alcohol Clin Exp Res (2012) 0.88

Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues. Alcohol Clin Exp Res (2013) 0.88

Caffeinated alcoholic beverages: an emerging public health problem. Am J Prev Med (2011) 0.88

Exploring the relationship between depressive and anxiety symptoms and neuronal response to alcohol cues. Alcohol Clin Exp Res (2009) 0.87

Reduced left executive control network functional connectivity is associated with alcohol use disorders. Alcohol Clin Exp Res (2014) 0.87

Sex differences in affective responses to homoerotic stimuli: evidence for an unconscious bias among heterosexual men, but not heterosexual women. Arch Sex Behav (2005) 0.87

Diagnosing alcohol abuse in alcohol dependent individuals: diagnostic and clinical implications. Addict Behav (2009) 0.87

Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults. J Cancer Epidemiol (2012) 0.87

COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use. Addict Biol (2011) 0.87

The relationship between impulsivity, risk-taking propensity and nicotine dependence among older adolescent smokers. Addict Behav (2012) 0.87

Consistent condom use among juvenile detainees: the role of individual differences, social bonding, and health beliefs. AIDS Behav (2007) 0.87

Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. Addict Biol (2011) 0.86

Diffusion tensor imaging of white matter networks in individuals with current and remitted alcohol use disorders and comorbid conditions. Psychol Addict Behav (2012) 0.85

Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation. Ann Behav Med (2013) 0.85

Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. Ann N Y Acad Sci (2013) 0.85

Behavioral control in alcohol use disorders: relationships with severity. J Stud Alcohol Drugs (2013) 0.85

Startle magnitude and prepulse inhibition: effects of alcohol and attention. Psychopharmacology (Berl) (2003) 0.84

Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy study. Psychiatry Res (2012) 0.84

Intrasexual Competition and Eating Restriction in Heterosexual and Homosexual Individuals. Evol Hum Behav (2010) 0.84

Consistency of self-reported alcohol consumption on randomized and sequential alcohol purchase tasks. Front Psychiatry (2012) 0.84

Personality correlates of pathological gambling derived from Big Three and Big Five personality models. Psychiatry Res (2012) 0.84

A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention. Psychiatry Res (2012) 0.84

Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. J Abnorm Child Psychol (2011) 0.83

Rare copy number deletions predict individual variation in human brain metabolite concentrations in individuals with alcohol use disorders. Biol Psychiatry (2011) 0.83

Effects of naltrexone during the descending limb of the blood alcohol curve. Am J Addict (2008) 0.83

Alcohol and the methylome: design and analysis considerations for research using human samples. Drug Alcohol Depend (2013) 0.82

Effects of naltrexone on cortisol levels in heavy drinkers. Pharmacol Biochem Behav (2008) 0.82