Published in J Physiol on August 28, 2008
Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov (2012) 1.42
Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol (2009) 1.05
Electrophysiology of reactive oxygen production in signaling endosomes. Antioxid Redox Signal (2009) 1.02
Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A (2009) 1.01
Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes. Proc Natl Acad Sci U S A (2009) 1.01
Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. J Neurosci (2010) 0.91
Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG. J Biol Chem (2011) 0.90
Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes. J Biol Chem (2011) 0.89
Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes. Proc Natl Acad Sci U S A (2013) 0.87
Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. J Physiol (2013) 0.80
Rab5 regulates internalisation of P2X4 receptors and potentiation by ivermectin. Purinergic Signal (2012) 0.79
Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A. J Physiol (2016) 0.79
Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel. J Biol Chem (2015) 0.77
Trafficking of an endogenous potassium channel in adult ventricular myocytes. Am J Physiol Cell Physiol (2012) 0.76
Autophagy is constitutively active in normal mouse sino-atrial nodal cells. Acta Histochem Cytochem (2011) 0.75
Angiotensin II reduces the surface abundance of KV1.5 channels in arterial myocytes to stimulate vasoconstriction. J Physiol (2016) 0.75
Rab proteins as membrane organizers. Nat Rev Mol Cell Biol (2001) 19.95
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell (1992) 10.53
Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol (1996) 9.27
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature (1998) 7.92
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol (1996) 7.65
Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A (2006) 6.83
Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J Cell Biol (1997) 6.57
The Rab5 effector EEA1 is a core component of endosome docking. Nature (1999) 5.78
The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol (1999) 4.45
Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol (2001) 4.09
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell (2006) 3.83
Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol (1992) 2.71
Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res (1997) 2.26
Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science (1996) 1.98
An endogenous MDCK lysosomal membrane glycoprotein is targeted basolaterally before delivery to lysosomes. J Cell Biol (1991) 1.81
Rab4 affects both recycling and degradative endosomal trafficking. FEBS Lett (2001) 1.65
Transferrin receptor recycling in the absence of perinuclear recycling endosomes. J Cell Biol (2002) 1.62
Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res (2007) 1.52
Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci (2004) 1.38
Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res (2005) 1.37
Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes. J Biol Chem (2007) 1.34
Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling. Proc Natl Acad Sci U S A (2004) 1.28
Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol (1997) 1.28
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic (2003) 1.27
Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin. Diabetologia (2000) 1.25
Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel. Mol Biol Cell (2004) 1.19
Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes. J Biol Chem (2006) 1.17
Mechanisms of cardiac potassium channel trafficking. J Physiol (2007) 1.09
Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Am J Physiol Cell Physiol (2006) 1.08
A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum. Mol Biol Cell (1996) 1.08
Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am J Physiol Heart Circ Physiol (2004) 1.06
Localization of Kv1.5 channels in rat and canine myocyte sarcolemma. FEBS Lett (2006) 0.97
Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. Biochem Biophys Res Commun (2005) 0.93
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol (2004) 1.96
A structural interpretation of voltage-gated potassium channel inactivation. Prog Biophys Mol Biol (2005) 1.86
The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis. Immunity (2011) 1.73
Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances. J Gen Physiol (2002) 1.41
KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther (2005) 1.40
Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res (2005) 1.37
Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+). J Physiol (2002) 1.29
Kv1.5 is an important component of repolarizing K+ current in canine atrial myocytes. Circ Res (2003) 1.24
Mechanisms of cardiac potassium channel trafficking. J Physiol (2007) 1.09
Dynamic of ion channel expression at the plasma membrane of cardiomyocytes. Physiol Rev (2012) 1.06
Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol (2009) 1.05
Cofactor molecules induce structural transformation during infectious prion formation. Structure (2013) 1.05
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. PLoS One (2010) 1.02
Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes. Proc Natl Acad Sci U S A (2009) 1.01
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents. Cardiovasc Res (2006) 1.00
A direct demonstration of closed-state inactivation of K+ channels at low pH. J Gen Physiol (2007) 1.00
Research into the therapeutic roles of two-pore-domain potassium channels. Trends Pharmacol Sci (2010) 0.99
N-terminal PDZ-binding domain in Kv1 potassium channels. FEBS Lett (2002) 0.98
Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels. J Biol Chem (2002) 0.98
Localization of Kv1.5 channels in rat and canine myocyte sarcolemma. FEBS Lett (2006) 0.97
Superoxide radical production by allopurinol and xanthine oxidase. Biochem Pharmacol (2006) 0.96
Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci (2005) 0.94
The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation. Cardiovasc Res (2013) 0.93
Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels. Am J Physiol Heart Circ Physiol (2008) 0.92
Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. J Biol Chem (2012) 0.91
Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH. Biophys J (2005) 0.90
Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs. J Gen Physiol (2010) 0.90
A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. J Biol Chem (2005) 0.90
Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition. J Gen Physiol (2003) 0.90
4-aminopyridine prevents the conformational changes associated with p/c-type inactivation in shaker channels. J Pharmacol Exp Ther (2006) 0.90
Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels. J Gen Physiol (2013) 0.90
Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks). Proc Natl Acad Sci U S A (2013) 0.90
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact. Genet Med (2008) 0.90
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A. J Med Chem (2014) 0.90
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). J Physiol (2014) 0.90
Contributions of intracellular ions to kv channel voltage sensor dynamics. Front Pharmacol (2012) 0.89
SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism. FEBS Lett (2003) 0.89
The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels. Mol Pharmacol (2007) 0.89
Normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method. Am J Physiol Cell Physiol (2010) 0.88
Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay. J Biomol Screen (2004) 0.88
Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations. J Gen Physiol (2012) 0.87
A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. Biochem Biophys Res Commun (2006) 0.87
Uncoupling of gating charge movement and closure of the ion pore during recovery from inactivation in the Kv1.5 channel. J Gen Physiol (2002) 0.86
Voltage clamp fluorimetry reveals a novel outer pore instability in a mammalian voltage-gated potassium channel. J Gen Physiol (2008) 0.85
Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore. J Gen Physiol (2009) 0.85
Environmental PCR survey to determine the distribution of a non-canonical genetic code in uncultivable oxymonads. Environ Microbiol (2008) 0.85
An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker. Biophys J (2007) 0.85
Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism. J Pharmacol Exp Ther (2008) 0.84
NH2-terminal inactivation peptide binding to C-type-inactivated Kv channels. J Gen Physiol (2004) 0.84
Modulation of human ether-à-go-go-related K+ (HERG) channel inactivation by Cs+ and K+. J Physiol (2003) 0.84
Flux assays in high throughput screening of ion channels in drug discovery. Assay Drug Dev Technol (2003) 0.84
Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation. J Physiol (2010) 0.84
Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels. J Physiol (2005) 0.83
Cholesterol and cardiac arrhythmias. Expert Rev Cardiovasc Ther (2010) 0.83
The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome. Expert Rev Mol Med (2011) 0.82
A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation. Heart Rhythm (2010) 0.82
The external K+ concentration and mutations in the outer pore mouth affect the inhibition of kv1.5 current by Ni2+. Biophys J (2004) 0.81
Closed-state inactivation induced in K(V)1 channels by extracellular acidification. Channels (Austin) (2008) 0.81
Complex expression and localization of inactivating Kv channels in cultured hippocampal astrocytes. J Neurophysiol (2005) 0.81
Increased focal Kv4.2 channel expression at the plasma membrane is the result of actin depolymerization. Am J Physiol Heart Circ Physiol (2003) 0.81
Gating currents from a Kv3 subfamily potassium channel: charge movement and modification by BDS-II toxin. J Physiol (2007) 0.80
The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel. Channels (Austin) (2009) 0.80
Diagnosis and treatment of zinc poisoning in a dog. Vet Hum Toxicol (2004) 0.80
SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5. Am J Physiol Cell Physiol (2006) 0.79
Rapid outer pore movements after opening in a KV1 potassium channel are revealed by TMRM fluorescence from the S3-S4 linker, and modulated by extracellular potassium. Channels (Austin) (2009) 0.79
Allosteric coupling of the inner activation gate to the outer pore of a potassium channel. Sci Rep (2013) 0.79
Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence. J Gen Physiol (2010) 0.79
Constitutive inactivation of the hKv1.5 mutant channel, H463G, in K+-free solutions at physiological pH. Cell Biochem Biophys (2005) 0.79
Block by internal Mg2+ causes voltage-dependent inactivation of Kv1.5. Eur Biophys J (2006) 0.78
Differential mitochondrial DNA and gene expression in inherited retinal dysplasia in miniature Schnauzer dogs. Invest Ophthalmol Vis Sci (2006) 0.78
Ranolazine improves diastolic function in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2014) 0.78
External Ba2+ block of human Kv1.5 at neutral and acidic pH: evidence for Ho+-induced constriction of the outer pore mouth at rest. Biophys J (2008) 0.78
Influenza A virus (H1N1) increases airway epithelial cell secretion by up-regulation of potassium channel KCNN4. Biochem Biophys Res Commun (2013) 0.77
Structure-based virtual screening and electrophysiological evaluation of new chemotypes of K(v)1.5 channel blockers. ChemMedChem (2010) 0.77
Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant. Biophys J (2011) 0.77
Non-reducing alkaline solubilization and rapid on-column refolding of recombinant prion protein. Prep Biochem Biotechnol (2012) 0.76
Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal. Heart Rhythm (2011) 0.76
The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium. Am J Physiol Cell Physiol (2013) 0.76
ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⁺ o-dependent resting inactivation. Pflugers Arch (2013) 0.76
Trafficking of an endogenous potassium channel in adult ventricular myocytes. Am J Physiol Cell Physiol (2012) 0.76