PubRank

J Silvio Gutkind

Author PubWeight™ 272.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 G-protein-coupled receptors and cancer. Nat Rev Cancer 2007 6.80
2 Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 2005 5.68
3 Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007 5.62
4 VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 2006 5.00
5 G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 2007 4.26
6 Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 2002 3.50
7 Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 2003 3.42
8 Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila) 2009 2.91
9 Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 2010 2.86
10 mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009 2.74
11 Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 2009 2.39
12 Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res 2003 2.34
13 Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 2007 2.21
14 Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 2008 2.21
15 Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J Am Chem Soc 2006 2.19
16 Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell 2008 2.13
17 An essential role for Rac1 in endothelial cell function and vascular development. FASEB J 2008 2.09
18 Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res 2005 2.07
19 The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer 2013 2.05
20 Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res 2004 2.05
21 Binding-induced folding of a natively unstructured transcription factor. PLoS Comput Biol 2008 2.04
22 mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell 2012 1.99
23 CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem 2008 1.93
24 Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev 2005 1.92
25 Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A 2011 1.85
26 The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell 2004 1.85
27 Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 2004 1.83
28 Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res 2008 1.83
29 Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol 2010 1.77
30 Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci U S A 2006 1.76
31 Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst 2010 1.73
32 Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem 2002 1.69
33 Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. ACS Nano 2009 1.68
34 P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem 2007 1.67
35 mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev 2002 1.63
36 The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 2006 1.63
37 Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem 2003 1.60
38 The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem 2006 1.58
39 The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A 2002 1.58
40 Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res 2011 1.54
41 Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. Cancer Res 2008 1.54
42 Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. Oncogene 2004 1.52
43 Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem 2002 1.52
44 Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A 2004 1.52
45 MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem 2007 1.51
46 Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res 2004 1.50
47 Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol 2010 1.50
48 Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 2002 1.49
49 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene 2002 1.46
50 A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal 2011 1.45
51 Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal Chem 2010 1.42
52 Viral hijacking of G-protein-coupled-receptor signalling networks. Nat Rev Mol Cell Biol 2004 1.42
53 Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol 2005 1.42
54 Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem 2007 1.41
55 A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell 2012 1.40
56 Robo4 signaling in endothelial cells implies attraction guidance mechanisms. J Biol Chem 2006 1.38
57 Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol 2003 1.38
58 Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res 2009 1.37
59 Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. J Biol Chem 2005 1.36
60 Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis. Clin Cancer Res 2006 1.36
61 Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma. Oncogene 2003 1.35
62 Potent activation of RhoA by Galpha q and Gq-coupled receptors. J Biol Chem 2002 1.35
63 Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. Biosens Bioelectron 2011 1.35
64 Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem 2012 1.34
65 mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res 2012 1.32
66 p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res 2012 1.32
67 Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. Anal Chem 2009 1.31
68 Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res 2012 1.30
69 Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res 2008 1.26
70 Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One 2010 1.25
71 Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem 2005 1.25
72 Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. J Biol Chem 2007 1.24
73 Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res 2009 1.24
74 Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 2008 1.23
75 Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. Carcinogenesis 2007 1.23
76 Down-regulation of CXCL5 inhibits squamous carcinogenesis. Cancer Res 2006 1.23
77 Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol 2007 1.22
78 E-cadherin and Hakai: signalling, remodeling or destruction? Nat Cell Biol 2002 1.22
79 Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med 2010 1.22
80 A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol 2009 1.21
81 Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. J Biol Chem 2008 1.21
82 P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett 2004 1.21
83 Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. FEBS Lett 2007 1.20
84 Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene 2002 1.19
85 Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6. Mol Cell Biol 2010 1.19
86 Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. PLoS One 2012 1.18
87 The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood 2004 1.17
88 Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res 2004 1.17
89 Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet 2012 1.16
90 Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene 2005 1.16
91 Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol Cancer Ther 2008 1.14
92 Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res 2008 1.14
93 Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem 2003 1.13
94 Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer 2004 1.13
95 Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles. Angew Chem Int Ed Engl 2011 1.12
96 Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila) 2009 1.12
97 The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. Cancer Res 2009 1.11
98 The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Cancer Res 2006 1.11
99 A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol 2010 1.11
100 Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J Biol Chem 2002 1.11
101 Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. Cancer Res 2006 1.11
102 Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila) 2012 1.10
103 Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? FASEB J 2004 1.10
104 PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci U S A 2010 1.08
105 Exploiting the mTOR paradox for disease prevention. Oncotarget 2012 1.07
106 Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms. Electrochem commun 2009 1.07
107 p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci 2004 1.07
108 Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res 2011 1.06
109 Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem 2008 1.06
110 Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal 2006 1.06
111 PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell 2011 1.06
112 Signaling circuitries controlling stem cell fate: to be or not to be. Curr Opin Cell Biol 2011 1.06
113 Role for EPS8 in squamous carcinogenesis. Carcinogenesis 2008 1.06
114 The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J Biol Chem 2003 1.05
115 PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene 2002 1.05
116 Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond) 2010 1.04
117 Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol 2006 1.04
118 Assembly and patterning of the vascular network of the vertebrate hindbrain. Development 2011 1.04
119 Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem 2003 1.03
120 Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One 2010 1.03
121 PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia 2013 1.03
122 Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res 2013 1.02
123 CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol 2002 1.01
124 Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. Cardiovasc Res 2006 1.01
125 Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes. Oncogene 2003 1.01
126 Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov 2013 1.01
127 Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res 2012 1.00
128 PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem 2013 0.99
129 Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta 2002 0.99
130 VE-cadherin and claudin-5: it takes two to tango. Nat Cell Biol 2008 0.99
131 TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle 2007 0.99
132 Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res 2014 0.99
133 Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein. J Biol Chem 2011 0.98
134 Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol 2012 0.97
135 A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res 2008 0.97
136 Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia 2013 0.95
137 Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res 2011 0.95
138 Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. J Biol Chem 2003 0.95
139 The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs 2010 0.95
140 Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem 2013 0.95
141 DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol 2012 0.95
142 A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer 2006 0.94
143 Scaffold proteins dictate Rho GTPase-signaling specificity. Trends Biochem Sci 2005 0.94
144 Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell 2007 0.94
145 Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury. Stem Cells 2015 0.93
146 Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol 2012 0.92
147 Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). Clin Cancer Res 2002 0.92
148 Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis. Oral Oncol 2005 0.91
149 mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma. Curr Treat Options Oncol 2012 0.91
150 Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway. FEBS Lett 2002 0.91
151 Nano delivers big: designing molecular missiles for cancer therapeutics. Pharmaceutics 2011 0.91
152 Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. Clin Cancer Res 2012 0.90
153 The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. J Biol Chem 2004 0.90
154 Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med 2013 0.90
155 EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. Carcinogenesis 2010 0.90
156 Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res 2012 0.90
157 Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis 2013 0.90
158 Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. Methods Enzymol 2004 0.89
159 Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer 2012 0.88
160 Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer 2014 0.88
161 Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer 2002 0.87
162 How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. J Am Chem Soc 2009 0.87
163 Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. Biochem Biophys Res Commun 2011 0.87
164 Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin. PLoS One 2012 0.86
165 TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget 2013 0.86
166 RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development. Clin Cancer Res 2008 0.86
167 Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression. Oral Oncol 2005 0.86
168 Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem 2013 0.86
169 Combining portable Raman probes with nanotubes for theranostic applications. Theranostics 2011 0.85
170 IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A 2013 0.84
171 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology 2009 0.84
172 Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation. J Phys Chem B 2006 0.84
173 Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS Nano 2014 0.84
174 CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood 2012 0.84
175 Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. J Biol Chem 2004 0.83
176 Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. Nanomedicine (Lond) 2009 0.83
177 Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. Oral Oncol 2005 0.83
178 Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity. Curr Opin Cell Biol 2013 0.82
179 Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients. J Periodontol 2011 0.82
180 Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol 2004 0.82
181 The biology of tobacco and nicotine: bench to bedside. Cancer Epidemiol Biomarkers Prev 2005 0.81
182 Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma. PLoS One 2013 0.81
183 The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis. J Biol Chem 2007 0.81
184 Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. ACS Nano 2012 0.81
185 Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Mol Cell Biochem 2011 0.81
186 Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat 2010 0.80
187 Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. J Biol Chem 2009 0.80
188 Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci 2014 0.80
189 A new G(q)-initiated MAPK signaling pathway in the heart. Dev Cell 2009 0.80
190 Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. Methods Mol Biol 2010 0.80
191 Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neurosignals 2006 0.80
192 Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol 2013 0.79
193 Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas 2014 0.79
194 Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. Int J Oncol 2007 0.79
195 Oral and pharyngeal epithelial keratinocyte culture. Methods Mol Biol 2013 0.79
196 Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration. Mol Pharmacol 2013 0.78
197 Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Res Cardiol 2014 0.78
198 Activation of MAPKs by G protein-coupled receptors. Methods Mol Biol 2004 0.78
199 Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report. Head Neck 2014 0.78
200 Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. Int J Oncol 2003 0.78
201 Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation. Methods Enzymol 2009 0.77
202 [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. Medicina (B Aires) 2012 0.77
203 MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat 2010 0.77
204 Keeping the epidermal stem cell niche in shape. Cell Stem Cell 2010 0.77
205 Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways. Vascul Pharmacol 2012 0.77
206 Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells. Immunology 2014 0.77
207 The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells. Anticancer Drugs 2005 0.76
208 Cellular systems for studying human oral squamous cell carcinomas. Adv Exp Med Biol 2011 0.76
209 Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacology 2003 0.76
210 mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis 2016 0.76
211 Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application. Cancer Chemother Pharmacol 2015 0.75
212 Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008. Head Neck 2009 0.75
213 Regulation of mitogen-activated protein kinases by G-protein-coupled receptors. Methods Enzymol 2002 0.75
214 [VE-cadherin takes a walk on the wild side]. Med Sci (Paris) 2007 0.75