|
1
|
Consensus nomenclature for in vivo imaging of reversibly binding radioligands.
|
J Cereb Blood Flow Metab
|
2007
|
11.79
|
|
2
|
Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release.
|
Neurosurgery
|
2003
|
2.21
|
|
3
|
Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression.
|
Arch Gen Psychiatry
|
2006
|
2.21
|
|
4
|
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET.
|
Am J Geriatr Psychiatry
|
2004
|
2.04
|
|
5
|
Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study.
|
Am J Psychiatry
|
2004
|
2.00
|
|
6
|
Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.
|
J Med Chem
|
2005
|
1.74
|
|
7
|
An automated method for the extraction of regional data from PET images.
|
Psychiatry Res
|
2006
|
1.67
|
|
8
|
Stimulation of the subthalamic nucleus and impulsivity: release your horses.
|
Ann Neurol
|
2009
|
1.62
|
|
9
|
Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors.
|
Nucl Med Biol
|
2008
|
1.58
|
|
10
|
Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.
|
Biol Psychiatry
|
2010
|
1.50
|
|
11
|
Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study.
|
J Neurosci
|
2012
|
1.48
|
|
12
|
Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.
|
J Neurochem
|
2006
|
1.42
|
|
13
|
Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study.
|
Biol Psychiatry
|
2007
|
1.40
|
|
14
|
First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study.
|
Neuropsychopharmacology
|
2007
|
1.38
|
|
15
|
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
|
Brain
|
2010
|
1.35
|
|
16
|
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
|
Am J Psychiatry
|
2003
|
1.30
|
|
17
|
Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes.
|
Arch Gen Psychiatry
|
2004
|
1.27
|
|
18
|
Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain.
|
J Cereb Blood Flow Metab
|
2006
|
1.26
|
|
19
|
Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence.
|
Arch Gen Psychiatry
|
2009
|
1.25
|
|
20
|
High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO.
|
Biol Psychiatry
|
2005
|
1.24
|
|
21
|
Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
|
Nucl Med Biol
|
2005
|
1.23
|
|
22
|
Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA.
|
J Cereb Blood Flow Metab
|
2012
|
1.22
|
|
23
|
Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics.
|
Am J Psychiatry
|
2004
|
1.21
|
|
24
|
Increased stress-induced dopamine release in psychosis.
|
Biol Psychiatry
|
2011
|
1.20
|
|
25
|
Elevated brain monoamine oxidase A binding in the early postpartum period.
|
Arch Gen Psychiatry
|
2010
|
1.20
|
|
26
|
Seasonal variation in human brain serotonin transporter binding.
|
Arch Gen Psychiatry
|
2008
|
1.19
|
|
27
|
Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study.
|
Am J Psychiatry
|
2006
|
1.15
|
|
28
|
The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride.
|
Addiction
|
2013
|
1.15
|
|
29
|
Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study.
|
Hum Brain Mapp
|
2009
|
1.13
|
|
30
|
Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
|
J Neurosci
|
2008
|
1.12
|
|
31
|
Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies.
|
J Cereb Blood Flow Metab
|
2013
|
1.12
|
|
32
|
Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.
|
Int J Neuropsychopharmacol
|
2009
|
1.10
|
|
33
|
Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain.
|
J Cereb Blood Flow Metab
|
2006
|
1.10
|
|
34
|
In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography.
|
Nucl Med Biol
|
2002
|
1.08
|
|
35
|
Bupropion occupancy of the dopamine transporter is low during clinical treatment.
|
Psychopharmacology (Berl)
|
2002
|
1.07
|
|
36
|
Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.
|
Bioorg Med Chem Lett
|
2005
|
1.07
|
|
37
|
[11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography.
|
Nucl Med Biol
|
2011
|
1.06
|
|
38
|
Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study.
|
Neurobiol Dis
|
2012
|
1.05
|
|
39
|
Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography.
|
J Cereb Blood Flow Metab
|
2011
|
1.05
|
|
40
|
Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study.
|
Eur J Neurosci
|
2008
|
1.05
|
|
41
|
Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter.
|
Nucl Med Biol
|
2003
|
1.03
|
|
42
|
D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats.
|
Neuropsychopharmacology
|
2008
|
1.01
|
|
43
|
Synthesis and in vitro evaluation of derivatives of the β₁-adrenergic receptor antagonist HX-CH 44.
|
Bioorg Med Chem Lett
|
2011
|
1.01
|
|
44
|
Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography.
|
Eur J Nucl Med Mol Imaging
|
2002
|
1.01
|
|
45
|
A positron emission tomography study of short- and long-term treatment effects on functional brain activation in adults who stutter.
|
J Fluency Disord
|
2003
|
1.00
|
|
46
|
Direct fixation of [(11)C]-CO(2) by amines: formation of [(11)C-carbonyl]-methylcarbamates.
|
Org Biomol Chem
|
2009
|
0.99
|
|
47
|
Extrastriatal dopaminergic dysfunction in tourette syndrome.
|
Ann Neurol
|
2010
|
0.99
|
|
48
|
Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking.
|
Arch Gen Psychiatry
|
2011
|
0.98
|
|
49
|
The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.
|
Arch Gen Psychiatry
|
2009
|
0.97
|
|
50
|
Oral D-amphetamine causes prolonged displacement of [11C]raclopride as measured by PET.
|
Synapse
|
2004
|
0.97
|
|
51
|
Serotonin 2A receptors and visual hallucinations in Parkinson disease.
|
Arch Neurol
|
2010
|
0.96
|
|
52
|
Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration.
|
Synapse
|
2008
|
0.96
|
|
53
|
Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.
|
Brain
|
2009
|
0.96
|
|
54
|
Dopamine-agonists and impulsivity in Parkinson's disease: impulsive choices vs. impulsive actions.
|
Hum Brain Mapp
|
2013
|
0.95
|
|
55
|
Dopaminergic activity in depressed smokers: a positron emission tomography study.
|
Synapse
|
2009
|
0.94
|
|
56
|
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
|
Bioorg Med Chem Lett
|
2012
|
0.94
|
|
57
|
Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: a [11C]FLB 457 PET study.
|
Neuroimage
|
2009
|
0.93
|
|
58
|
Mapping human brain fatty acid amide hydrolase activity with PET.
|
J Cereb Blood Flow Metab
|
2012
|
0.93
|
|
59
|
Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.
|
J Med Chem
|
2012
|
0.93
|
|
60
|
Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.
|
Mov Disord
|
2008
|
0.93
|
|
61
|
Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo.
|
J Nucl Med
|
2009
|
0.92
|
|
62
|
Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO.
|
Schizophr Res
|
2011
|
0.92
|
|
63
|
[11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats.
|
Synapse
|
2003
|
0.92
|
|
64
|
Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol.
|
Chem Commun (Camb)
|
2009
|
0.91
|
|
65
|
Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats.
|
Biol Psychiatry
|
2004
|
0.90
|
|
66
|
Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment.
|
Brain
|
2013
|
0.90
|
|
67
|
The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics.
|
Int J Neuropsychopharmacol
|
2009
|
0.89
|
|
68
|
Synthesis and application of isocyanates radiolabeled with carbon-11.
|
Chemistry
|
2010
|
0.89
|
|
69
|
Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.
|
Molecules
|
2010
|
0.89
|
|
70
|
Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections.
|
Int J Geriatr Psychiatry
|
2011
|
0.88
|
|
71
|
Effects of tryptophan depletion on the serotonin transporter in healthy humans.
|
Biol Psychiatry
|
2005
|
0.88
|
|
72
|
Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase.
|
Nucl Med Biol
|
2013
|
0.88
|
|
73
|
Side effects profile in humans of (11)C-(+)-PHNO, a dopamine D(2/3) agonist ligand for PET.
|
J Nucl Med
|
2010
|
0.87
|
|
74
|
Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO.
|
Nucl Med Biol
|
2007
|
0.87
|
|
75
|
[¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders.
|
Mov Disord
|
2015
|
0.86
|
|
76
|
Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease.
|
Ann Neurol
|
2014
|
0.86
|
|
77
|
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
|
Nucl Med Biol
|
2011
|
0.85
|
|
78
|
Development of new radiopharmaceuticals for imaging monoamine oxidase B.
|
Nucl Med Biol
|
2011
|
0.85
|
|
79
|
Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.
|
Bioorg Med Chem
|
2013
|
0.84
|
|
80
|
Convergent effects of acute stress and glucocorticoid exposure upon MAO-A in humans.
|
J Neurosci
|
2012
|
0.84
|
|
81
|
Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease.
|
Hum Brain Mapp
|
2012
|
0.84
|
|
82
|
Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor.
|
J Nucl Med
|
2012
|
0.83
|
|
83
|
Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies.
|
J Cereb Blood Flow Metab
|
2011
|
0.83
|
|
84
|
Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia.
|
Neuropsychiatr Dis Treat
|
2011
|
0.83
|
|
85
|
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.
|
Synapse
|
2010
|
0.83
|
|
86
|
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making.
|
Brain Stimul
|
2012
|
0.83
|
|
87
|
Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study.
|
Soc Neurosci
|
2010
|
0.82
|
|
88
|
Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits.
|
J Psychiatr Res
|
2012
|
0.81
|
|
89
|
Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [11C]-+-PHNO.
|
Neuropsychopharmacology
|
2012
|
0.81
|
|
90
|
Benign hereditary chorea: clinical, genetic, and pathological findings.
|
Ann Neurol
|
2003
|
0.81
|
|
91
|
Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography.
|
Psychopharmacology (Berl)
|
2007
|
0.81
|
|
92
|
Imaging changes associated with cognitive abnormalities in Parkinson's disease.
|
Brain Struct Funct
|
2014
|
0.81
|
|
93
|
A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease.
|
Am J Geriatr Psychiatry
|
2007
|
0.80
|
|
94
|
Serotonin2A receptor binding potential in people with aggressive and violent behaviour.
|
J Psychiatry Neurosci
|
2008
|
0.80
|
|
95
|
Serotonin-1A receptors in frontotemporal dementia compared with controls.
|
Psychiatry Res
|
2007
|
0.80
|
|
96
|
Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study.
|
J Psychiatry Neurosci
|
2011
|
0.80
|
|
97
|
Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa).
|
Mol Imaging Biol
|
2013
|
0.80
|
|
98
|
Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study.
|
Biol Psychiatry
|
2004
|
0.79
|
|
99
|
Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET.
|
J Cereb Blood Flow Metab
|
2013
|
0.79
|
|
100
|
Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine.
|
Synapse
|
2004
|
0.79
|
|
101
|
Quantitative imaging of neuroinflammation in human white matter: a positron emission tomography study with translocator protein 18 kDa radioligand, [18F]-FEPPA.
|
Synapse
|
2014
|
0.79
|
|
102
|
Prefrontal D2-receptor stimulation mediates flexible adaptation of economic preference hierarchies.
|
Hum Brain Mapp
|
2011
|
0.79
|
|
103
|
Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task.
|
J Psychiatry Neurosci
|
2013
|
0.79
|
|
104
|
Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635.
|
Arch Gen Psychiatry
|
2002
|
0.79
|
|
105
|
Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults.
|
BMC Med Imaging
|
2009
|
0.79
|
|
106
|
Analysis of variance in neuroreceptor ligand imaging studies.
|
PLoS One
|
2011
|
0.78
|
|
107
|
In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system.
|
Synapse
|
2006
|
0.78
|
|
108
|
A case of apathy due to frontotemporal dementia responsive to memantine.
|
Neurocase
|
2012
|
0.78
|
|
109
|
Positron-emission tomography imaging of the TSPO with [(18)F]FEPPA in a preclinical breast cancer model.
|
Cancer Biother Radiopharm
|
2013
|
0.78
|
|
110
|
Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study.
|
J Cereb Blood Flow Metab
|
2011
|
0.78
|
|
111
|
Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.
|
Bioorg Med Chem
|
2012
|
0.78
|
|
112
|
Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study.
|
PLoS One
|
2013
|
0.78
|
|
113
|
Biodistribution and radiation dosimetry of the serotonin 5-HT₆ ligand [¹¹C]GSK215083 determined from human whole-body PET.
|
Mol Imaging Biol
|
2012
|
0.77
|
|
114
|
Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study.
|
Int J Geriatr Psychiatry
|
2012
|
0.77
|
|
115
|
An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP.
|
Appl Radiat Isot
|
2008
|
0.77
|
|
116
|
Radiosynthesis, ex vivo and in vivo evaluation of [11C]preclamol as a partial dopamine D2 agonist radioligand for positron emission tomography.
|
Synapse
|
2006
|
0.77
|
|
117
|
Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats.
|
Synapse
|
2004
|
0.77
|
|
118
|
Up-regulated dopamine D1 receptor binding can be detected in vivo following repeated SCH 23390, but not SKF 81297 or 6-hydroxydopamine, treatments.
|
Eur J Pharmacol
|
2003
|
0.76
|
|
119
|
No change in dopamine D1 receptor in vivo binding in rats after sub-chronic haloperidol treatment.
|
Can J Physiol Pharmacol
|
2002
|
0.76
|
|
120
|
Synthesis and preliminary evaluation of [(18)F]-fluoro-(2S)-Exaprolol for imaging cerebral beta-adrenergic receptors with PET.
|
Neurochem Int
|
2008
|
0.76
|
|
121
|
Misunderstandings about how to choose a reference region.
|
Biol Psychiatry
|
2006
|
0.76
|
|
122
|
4-Bromo-8-methoxy-quinoline.
|
Acta Crystallogr Sect E Struct Rep Online
|
2008
|
0.75
|
|
123
|
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
124
|
Whole-body distribution and radiation dosimetry of 11C-(+)-PHNO, a D2/3 agonist ligand.
|
J Nucl Med
|
2012
|
0.75
|
|
125
|
Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol.
|
J Med Chem
|
2008
|
0.75
|