Published in Autophagy on November 20, 2008
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy (2009) 2.09
Autophagy in cellular growth control. FEBS Lett (2010) 1.74
Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res (2012) 1.43
MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. J Biol Chem (2011) 1.36
Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma. PLoS One (2013) 1.16
Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death Dis (2014) 1.08
Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther (2013) 1.01
Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. PLoS One (2013) 0.96
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation. Cell Death Dis (2014) 0.92
Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC Gastroenterol (2012) 0.91
Involvement of autophagy in ovarian cancer: a working hypothesis. J Ovarian Res (2012) 0.89
Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis. Int J Mol Sci (2014) 0.87
Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. PLoS One (2013) 0.87
The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma. PLoS One (2013) 0.87
Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. PLoS One (2012) 0.84
Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. Int J Clin Exp Pathol (2015) 0.83
Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer. Biomed Res Int (2014) 0.82
The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance. BMC Cancer (2014) 0.82
Parkin and mitophagy in cancer. Oncogene (2016) 0.81
Epigenetic control of autophagy by microRNAs in ovarian cancer. Biomed Res Int (2014) 0.81
Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response. Hepat Med (2016) 0.79
Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions. Respir Res (2015) 0.78
Modulating autophagy: a strategy for cancer therapy. Chin J Cancer (2011) 0.78
Expression pattern of autophagy-related markers in non-metastatic clear cell renal cell carcinoma: association with disease recurrence following radical nephrectomy. J Cancer Res Clin Oncol (2015) 0.77
The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer. Med Oncol (2013) 0.77
Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis. Braz J Med Biol Res (2014) 0.76
The pro-social neurohormone oxytocin reverses the actions of the stress hormone cortisol in human ovarian carcinoma cells in vitro. Int J Oncol (2016) 0.75
Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational trophoblastic disease. Iran J Reprod Med (2015) 0.75
Hepatoma-derived growth factor predicts unfavorable prognosis of epithelial ovarian cancer. Onco Targets Ther (2015) 0.75
Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy. BMC Cancer (2016) 0.75
Autophagy as an emerging therapy target for ovarian carcinoma. Oncotarget (2016) 0.75
Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells. Oncotarget (2016) 0.75
Expression levels of autophagy related proteins and their prognostic significance in retinocytoma and retinoblastoma. Int J Ophthalmol (2014) 0.75
Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer. Oncotarget (2016) 0.75
Biological determinants of radioresistance and their remediation in pancreatic cancer. Biochim Biophys Acta (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem (2008) 1.78
The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy (2009) 1.64
Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB. J Transl Med (2009) 1.48
The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. Cancer Biol Ther (2005) 1.46
A strategy for risk mitigation of antibodies with fast clearance. MAbs (2013) 1.42
Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines. Ann Surg Oncol (2011) 1.41
Variable sensitivity of endothelial cells to epirubicin in xenografts of human nasopharyngeal carcinoma CNE-2 cells. Cancer Biol Ther (2002) 1.38
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J (2014) 1.36
Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp. Chem Biodivers (2011) 1.35
Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis (2008) 1.30
A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. Chin J Cancer (2010) 1.28
Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors. Stem Cells (2009) 1.20
α-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest (2014) 1.18
Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells. Cell Cycle (2007) 1.17
Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst (2012) 1.15
Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma. J Transl Med (2010) 1.13
Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy (2010) 1.13
Structure, function and polymorphism of human cytosolic sulfotransferases. Curr Drug Metab (2008) 1.06
Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. J Pharmacol Sci (2012) 1.06
Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway. Am J Physiol Heart Circ Physiol (2010) 1.04
Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells. Toxicol Appl Pharmacol (2011) 1.04
ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts. Int J Cancer (2008) 1.03
Isolation and structural elucidation of chondrosterins F-H from the marine fungus Chondrostereum sp. Mar Drugs (2013) 1.02
G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Mol Cancer Ther (2009) 1.00
Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma. PLoS One (2013) 1.00
Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients. Int J Cancer (2009) 0.99
siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression. Cancer Lett (2006) 0.99
The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. Int J Oncol (2012) 0.97
Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem (2005) 0.97
Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. PLoS One (2013) 0.96
Ligament regeneration using a knitted silk scaffold combined with collagen matrix. Biomaterials (2008) 0.95
ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway. J Transl Med (2009) 0.94
Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge. MAbs (2014) 0.94
Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Sci (2011) 0.94
DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther (2013) 0.94
SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway. Int J Cancer (2010) 0.92
SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1. Mol Cancer (2014) 0.92
VIKOR method with enhanced accuracy for multiple criteria decision making in healthcare management. J Med Syst (2013) 0.92
Houttuyninum, an active constituent of Chinese herbal medicine, inhibits phosphorylation of HER2/neu receptor tyrosine kinase and the tumor growth of HER2/neu-overexpressing cancer cells. Life Sci (2012) 0.91
Novel sorbicillin analogues from the marine fungus Trichoderma sp. associated with the seastar Acanthaster planci. Nat Prod Commun (2012) 0.91
Traditional Chinese medicine Qing Yi Tang alleviates oxygen free radical injury in acute necrotizing pancreatits. World J Gastroenterol (1998) 0.90
Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cell Signal (2012) 0.90
The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment. PLoS One (2012) 0.90
Fungal infection in patients after liver transplantation in years 2003 to 2012. Ann Transplant (2012) 0.89
Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. Acta Pharmacol Sin (2007) 0.89
Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells. Chin J Cancer (2011) 0.88
Novel compound heterozygous mutations T2C and 1149insT in the KCNQ1 gene cause Jervell and Lange-Nielsen syndrome. Int J Mol Med (2011) 0.88
The mutation profiles of common oncogenes involved in melanoma in southern China. J Invest Dermatol (2012) 0.88
Randomized control study of nedaplatin or cisplatin concomitant with other chemotherapy in the treatment of advanced non-small cell lung cancer. Asian Pac J Cancer Prev (2014) 0.88
Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells. PLoS One (2010) 0.88
Steroid elimination within 24 hours after orthotopic liver transplantation: effectiveness and tolerability. Hepatobiliary Pancreat Dis Int (2012) 0.88
Orthotopic liver transplantation for fulminant hepatitis B. World J Gastroenterol (2000) 0.87
One-pot formation of C-C and C-N bonds through palladium-catalyzed dual C-H activation: synthesis of phenanthridinones. Angew Chem Int Ed Engl (2011) 0.87
ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells. Autophagy (2015) 0.87
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients. Breast Cancer Res Treat (2012) 0.87
ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther (2009) 0.86
Smad 1/5 is involved in bone morphogenetic protein-2-induced odontoblastic differentiation in human dental pulp cells. J Endod (2011) 0.86
Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol (2009) 0.85
ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leuk Res (2009) 0.84
Graft-verse-host disease after liver transplantation: a report of two cases and review of literature. World J Gastroenterol (2008) 0.84
Acoustic radiation force impulse elastography for differentiation of benign and malignant thyroid nodules with concurrent Hashimoto's thyroiditis. Med Oncol (2015) 0.84
Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem (2006) 0.84
Expression analysis and binding experiments of chemosensory proteins indicate multiple roles in Bombyx mori. J Insect Physiol (2013) 0.83
Novel biodegradable three-dimensional macroporous scaffold using aligned electrospun nanofibrous yarns for bone tissue engineering. J Biomed Mater Res A (2012) 0.83
The p33ING1b tumor suppressor cooperates with p53 to induce apoptosis in response to etoposide in human osteosarcoma cells. Life Sci (2005) 0.83
Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem (2012) 0.83
A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci (2013) 0.83
Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition. World J Gastroenterol (2012) 0.83
Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey. Eur J Pharm Sci (2013) 0.83
Proteasome inhibitor MG-132 modifies coxsackie and adenovirus receptor expression in colon cancer cell line lovo. Cell Cycle (2008) 0.82
Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study. J Immunol Methods (2009) 0.82
Expression of c-Src and phospho-Src in epithelial ovarian carcinoma. Mol Cell Biochem (2013) 0.82
Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats. Brain Cell Biol (2009) 0.82
ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biol Ther (2009) 0.82
Clinical and pathological analysis of acute rejection following orthotopic liver transplantation. Chin Med J (Engl) (2009) 0.82