Identification of proteins adducted by lipid peroxidation products in plasma and modifications of apolipoprotein A1 with a novel biotinylated phospholipid probe.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMC 2664612)

Published in J Proteome Res on September 09, 2008

Authors

Matthew E Szapacs1, Hye-Young H Kim, Ned A Porter, Daniel C Liebler

Author Affiliations

1: Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232-0146, USA.

Articles citing this

Formation and signaling actions of electrophilic lipids. Chem Rev (2011) 1.82

Transduction of redox signaling by electrophile-protein reactions. Sci Signal (2009) 1.62

Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction. J Am Coll Cardiol (2012) 1.55

An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. Mol Cell Proteomics (2009) 1.52

The role of oxidized phospholipids in atherosclerosis. J Lipid Res (2008) 1.51

Role of phospholipid oxidation products in atherosclerosis. Circ Res (2012) 1.41

Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase. Circ Res (2014) 1.21

Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem (2010) 1.19

Dysfunctional HDL as a diagnostic and therapeutic target. Arterioscler Thromb Vasc Biol (2009) 1.17

The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function. Antioxid Redox Signal (2012) 1.08

Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res (2013) 1.04

Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses. Biochim Biophys Acta (2012) 1.00

A capture method based on the VC1 domain reveals new binding properties of the human receptor for advanced glycation end products (RAGE). Redox Biol (2016) 0.89

Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL. Biochim Biophys Acta (2011) 0.89

Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant. Chem Res Toxicol (2010) 0.86

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1. J Biol Chem (2011) 0.86

Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration. Proteomics Clin Appl (2013) 0.86

Esterified eicosanoids: generation, characterization and function. Biochim Biophys Acta (2011) 0.85

Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. Chem Res Toxicol (2009) 0.85

Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin. PLoS One (2014) 0.84

Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal. Chem Res Toxicol (2010) 0.83

Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development. Toxics (2015) 0.83

Proteins modified by the lipid peroxidation aldehyde 9,12-dioxo-10(E)-dodecenoic acid in MCF7 breast cancer cells. Chem Res Toxicol (2010) 0.80

Role of lipid peroxidation-derived α, β-unsaturated aldehydes in vascular dysfunction. Oxid Med Cell Longev (2013) 0.80

A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood. J Clin Biochem Nutr (2013) 0.80

Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. J Am Chem Soc (2010) 0.79

Novel approaches to identify protein adducts produced by lipid peroxidation. Free Radic Res (2015) 0.77

Analysis of covalent modifications of proteins by oxidized phospholipids using a novel method of peptide enrichment. Anal Chem (2014) 0.77

A filtered database search algorithm for endogenous serum protein carbonyl modifications in a mouse model of inflammation. Mol Cell Proteomics (2011) 0.76

HDL inhibits the effects of oxidized phospholipids on endothelial cell gene expression via multiple mechanisms. J Lipid Res (2014) 0.76

Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses. Genet Sel Evol (2017) 0.75

Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation. Chem Res Toxicol (2016) 0.75

Articles cited by this

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J Am Soc Mass Spectrom (1994) 45.51

The free radical theory of aging matures. Physiol Rev (1998) 9.83

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science (1983) 9.38

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet (1994) 6.71

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med (2007) 4.11

Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem (1997) 3.91

Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science (2001) 3.83

Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63

Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev (2006) 3.26

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem (2002) 3.17

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13

Mechanisms of free radical oxidation of unsaturated lipids. Lipids (1995) 3.07

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem (2002) 2.94

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc Natl Acad Sci U S A (1999) 2.85

Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol (2005) 2.77

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat Struct Mol Biol (2007) 2.47

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J Clin Invest (2003) 2.41

Sequential flotation ultracentrifugation. Methods Enzymol (1986) 2.27

HDL cholesterol and protective factors in atherosclerosis. Circulation (2004) 2.25

C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci U S A (2002) 2.20

DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res (2001) 2.09

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res (2002) 1.97

Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. J Biol Chem (2006) 1.95

Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal. Chem Res Toxicol (2002) 1.92

A role for oxidized phospholipids in atherosclerosis. N Engl J Med (2005) 1.89

Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J Biol Chem (2001) 1.87

Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages. J Biol Chem (2004) 1.80

Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol (2000) 1.74

Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. J Pharmacol Exp Ther (2005) 1.71

Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. J Biol Chem (2004) 1.71

Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I. Profiling an unfractionated tryptic digest. Proteomics (2001) 1.68

Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem (2001) 1.67

P-Mod: an algorithm and software to map modifications to peptide sequences using tandem MS data. J Proteome Res (2005) 1.65

Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. Chem Res Toxicol (2005) 1.61

Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein. J Biol Chem (1999) 1.58

Formation of dysfunctional high-density lipoprotein by myeloperoxidase. Trends Cardiovasc Med (2005) 1.47

Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts. J Biol Chem (1999) 1.47

4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chem Res Toxicol (2005) 1.46

Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. J Biol Chem (2001) 1.44

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic Biol Med (2002) 1.34

Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities. J Biol Chem (2005) 1.33

Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal. Chem Res Toxicol (2004) 1.32

Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem (2005) 1.27

4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Mol Pharmacol (2006) 1.21

Data-controlled automation of liquid chromatography/tandem mass spectrometry analysis of peptide mixtures. J Am Soc Mass Spectrom (1996) 1.20

Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions. Biochemistry (2006) 1.16

Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem (2004) 1.15

Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chem Res Toxicol (2003) 1.15

Relationship between the concentration and antiatherogenic activity of high-density lipoproteins. Curr Opin Lipidol (2006) 1.02

Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides. Chem Res Toxicol (2007) 1.02

Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presence of cytochrome c. Chem Res Toxicol (2007) 1.01

Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. Chem Res Toxicol (2007) 0.96

First direct evidence for lipid/protein conjugation in oxidized human low density lipoprotein. J Biol Chem (1996) 0.94

Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal. Biochemistry (2003) 0.89

Acrolein modifies apolipoprotein A-I in the human artery wall. Ann N Y Acad Sci (2005) 0.86

Future of toxicology--lipidomics, an important emerging area for toxicologists: focus on lipid oxidation products. Chem Res Toxicol (2007) 0.85

Mapping disulfide connectivity using backbone ester hydrolysis. Biochemistry (1999) 0.85

Proteomics of lipid oxidation-induced oxidation of porcine and bovine oxymyoglobins. Proteomics (2007) 0.85

New developments in the isoprostane pathway: identification of novel highly reactive gamma-ketoaldehydes (isolevuglandins) and characterization of their protein adducts. FASEB J (1999) 0.83

Future of toxicology--lipid peroxidation in the future: from biomarker to etiology. Chem Res Toxicol (2007) 0.82

Articles by these authors

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics (2010) 13.35

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab (2012) 4.80

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res (2010) 3.08

Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A (2006) 2.58

Sample preparation and digestion for proteomic analyses using spin filters. Proteomics (2005) 2.49

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics (2009) 2.39

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem (2005) 2.37

Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics (2014) 2.37

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chem Biol (2007) 2.29

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol (2005) 2.22

Free radical lipid peroxidation: mechanisms and analysis. Chem Rev (2011) 2.17

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics (2009) 2.09

Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal. Mol Cell Proteomics (2008) 1.89

Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chem Res Toxicol (2008) 1.82

Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J Biol Chem (2008) 1.76

Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol (2006) 1.69

Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol Cell Proteomics (2009) 1.66

P-Mod: an algorithm and software to map modifications to peptide sequences using tandem MS data. J Proteome Res (2005) 1.65

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A (2002) 1.63

Protein identification using customized protein sequence databases derived from RNA-Seq data. J Proteome Res (2011) 1.62

Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. J Am Chem Soc (2009) 1.58

Global shifts in protein sumoylation in response to electrophile and oxidative stress. Chem Res Toxicol (2004) 1.57

Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics (2012) 1.55

Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry. J Proteome Res (2008) 1.55

Methods for peptide and protein quantitation by liquid chromatography-multiple reaction monitoring mass spectrometry. Mol Cell Proteomics (2011) 1.54

An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. Mol Cell Proteomics (2009) 1.52

Depletion of abundant plasma proteins and limitations of plasma proteomics. J Proteome Res (2010) 1.52

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3. Chem Res Toxicol (2008) 1.47

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. J Lipid Res (2010) 1.44

Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling. J Proteome Res (2010) 1.43

New insights regarding the autoxidation of polyunsaturated fatty acids. Antioxid Redox Signal (2005) 1.42

Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. J Thorac Oncol (2007) 1.40

Reversibility of covalent electrophile-protein adducts and chemical toxicity. Chem Res Toxicol (2008) 1.38

Proteomic identification of ubiquitinated proteins from human cells expressing His-tagged ubiquitin. Proteomics (2005) 1.37

Protein targets of reactive electrophiles in human liver microsomes. Chem Res Toxicol (2007) 1.34

A bioinformatics workflow for variant peptide detection in shotgun proteomics. Mol Cell Proteomics (2011) 1.34

Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies. J Am Chem Soc (2010) 1.27

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 1.25

Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem (2006) 1.25

Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. J Am Chem Soc (2003) 1.23

Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins. Methods Enzymol (2010) 1.23

Spin filter-based sample preparation for shotgun proteomics. Nat Methods (2009) 1.21

Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium. Cancer Discov (2013) 1.20

Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies. J Proteome Res (2013) 1.20

Network-assisted protein identification and data interpretation in shotgun proteomics. Mol Syst Biol (2009) 1.19

DNA-protein cross-linking by 1,2,3,4-diepoxybutane. J Proteome Res (2010) 1.17

Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions. Biochemistry (2006) 1.16

Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem (2008) 1.15

Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med (2009) 1.14

Alkylation damage by lipid electrophiles targets functional protein systems. Mol Cell Proteomics (2014) 1.13

Peroxyl radical clocks. J Org Chem (2006) 1.13

Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Proc Natl Acad Sci U S A (2007) 1.12

Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol (2008) 1.12

Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J Biol Chem (2003) 1.11

The development of selected reaction monitoring methods for targeted proteomics via empirical refinement. Proteomics (2012) 1.10

Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics. Clin Chem (2009) 1.10

Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem (2006) 1.09

QuaMeter: multivendor performance metrics for LC-MS/MS proteomics instrumentation. Anal Chem (2012) 1.08

Supporting tool suite for production proteomics. Bioinformatics (2011) 1.08

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Free Radic Biol Med (2010) 1.08

Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios. Chem Res Toxicol (2010) 1.07

Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. J Biol Chem (2011) 1.07

Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration. Clin Chem (2009) 1.07

In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. Mol Cell Proteomics (2012) 1.06

DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiol Dis (2011) 1.05

Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides. J Proteome Res (2012) 1.05

Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2012) 1.04

Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem (2008) 1.04

Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Anal Chem (2003) 1.03

Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem Res Toxicol (2009) 1.03

Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. J Lipid Res (2013) 1.02

Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks. Acc Chem Res (2011) 1.01

Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Anal Chem (2005) 1.01

Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. J Biol Chem (2005) 1.01

Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Chem Res Toxicol (2004) 1.01

Proteomic consequences of a single gene mutation in a colorectal cancer model. J Proteome Res (2011) 1.01

Sequence tagging reveals unexpected modifications in toxicoproteomics. Chem Res Toxicol (2011) 1.00

Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 0.99

Quantitative analysis of modified proteins by LC-MS/MS of peptides labeled with phenyl isocyanate. J Proteome Res (2003) 0.99

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Nat Chem Biol (2010) 0.99

Relating protein adduction to gene expression changes: a systems approach. Mol Biosyst (2011) 0.99

Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem (2002) 0.99

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radic Biol Med (2012) 0.99

Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. J Biol Chem (2003) 0.98

Identification of a novel class of endoperoxides from arachidonate autoxidation. J Biol Chem (2003) 0.98

Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J Proteome Res (2011) 0.98

Factors influencing the autoxidation of fatty acids: effect of olefin geometry of the nonconjugated diene. J Am Chem Soc (2004) 0.98

Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circ Res (2007) 0.98

Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Biochemistry (2006) 0.98

Alkylation of cytochrome c by (glutathion-S-yl)-1,4-benzoquinone and iodoacetamide demonstrates compound-dependent site specificity. Chem Res Toxicol (2005) 0.98

Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage. Biochemistry (2006) 0.97

7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochim Biophys Acta (2012) 0.96

Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. Chem Res Toxicol (2007) 0.96

Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal. Chem Res Toxicol (2011) 0.96