Published in Am J Pathol on September 11, 2008
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A (2009) 3.39
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol (2011) 2.33
Role of IL-33 in inflammation and disease. J Inflamm (Lond) (2011) 2.06
Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem (2009) 2.00
Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J Biol Chem (2012) 1.55
IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS One (2010) 1.54
Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. J Clin Invest (2016) 1.43
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity (2015) 1.37
The enigmatic processing and secretion of interleukin-33. Cell Mol Immunol (2010) 1.32
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat Immunol (2012) 1.28
Changes of the cytokine profile in inflammatory bowel diseases. World J Gastroenterol (2012) 1.23
Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Hum Mol Genet (2014) 1.23
Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology (2012) 1.21
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol (2010) 1.21
Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages. BMC Immunol (2010) 1.13
Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim Biophys Acta (2013) 1.10
IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol (2014) 1.09
Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A (2013) 1.09
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy. Br J Pharmacol (2009) 1.08
Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature. J Mol Cell Cardiol (2013) 1.08
IL-33 and Airway Inflammation. Allergy Asthma Immunol Res (2011) 1.07
Novel cytokine signaling pathways in inflammatory bowel disease: insight into the dichotomous functions of IL-33 during chronic intestinal inflammation. Therap Adv Gastroenterol (2011) 1.07
Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol (2016) 1.04
Expression and regulation of interleukin-33 in human monocytes. Immunology (2010) 1.04
The role of IL-33 in gut mucosal inflammation. Mediators Inflamm (2013) 1.00
IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol (2014) 0.99
Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33. Proc Natl Acad Sci U S A (2015) 0.99
IL-33 regulates TNF-α dependent effects in synovial fibroblasts. Int J Mol Med (2012) 0.95
Interleukin-33 in health and disease. Nat Rev Immunol (2016) 0.92
Implications for Interleukin-33 in solid organ transplantation. Cytokine (2013) 0.89
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PLoS One (2014) 0.89
Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model. Am J Pathol (2011) 0.87
Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor [corrected] of matrix metalloproteinase-1 in myocardial infarction. Korean J Intern Med (2013) 0.87
Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway. J Immunol (2012) 0.84
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol (2015) 0.83
Interleukin-33 in the human placenta. J Matern Fetal Neonatal Med (2012) 0.82
Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia. Arterioscler Thromb Vasc Biol (2012) 0.81
Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis. Ann Clin Transl Neurol (2014) 0.80
CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest. Histochem Cell Biol (2012) 0.79
Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis. Sci Rep (2016) 0.78
Red Blood Cells Store and Release Interleukin-33. J Investig Med (2015) 0.78
Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment. Transfus Med Hemother (2016) 0.78
Serum soluble ST2 is associated with ER-positive breast cancer. BMC Cancer (2014) 0.78
Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells. Sci Rep (2016) 0.77
Serglycin in Quiescent and Proliferating Primary Endothelial Cells. PLoS One (2015) 0.77
Serum IL-33 level and IL-33 gene polymorphisms in Behçet's disease. Rheumatol Int (2014) 0.76
Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients With Rheumatoid Arthritis. Arthritis Rheumatol (2016) 0.75
ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples. PLoS One (2016) 0.75
Interleukin-33 in human gliomas: Expression and prognostic significance. Oncol Lett (2016) 0.75
Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study. Dis Markers (2016) 0.75
Nasal administration of interleukin-33 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma surrogate. Immunology (2016) 0.75
Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant (2016) 0.75
A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer. PLoS One (2017) 0.75
Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury. Sci Rep (2017) 0.75
IL-33 and the intestine: The good, the bad, and the inflammatory. Cytokine (2017) 0.75
Inflammation and cancer. Nature (2002) 53.78
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest (1973) 31.28
Inflammation and cancer: back to Virchow? Lancet (2001) 27.40
The retinoblastoma protein and cell cycle control. Cell (1995) 20.21
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med (1986) 17.64
The Ki-67 protein: from the known and the unknown. J Cell Physiol (2000) 16.48
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (1983) 15.43
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity (2005) 14.95
Tumorigenesis and the angiogenic switch. Nat Rev Cancer (2003) 11.95
Angiogenesis as a therapeutic target. Nature (2005) 11.89
Regulation of wound healing by growth factors and cytokines. Physiol Rev (2003) 9.82
HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol (1992) 6.50
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A (2006) 5.08
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest (2007) 4.31
Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature (1990) 4.21
PCNA: structure, functions and interactions. Oncogene (1997) 3.91
IL-33 reduces the development of atherosclerosis. J Exp Med (2008) 3.59
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med (1989) 3.58
Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci U S A (1997) 3.30
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol (2007) 2.93
Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest (2000) 2.92
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol (2008) 2.78
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol (2003) 2.72
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A (2004) 2.61
IL-33 is a chemoattractant for human Th2 cells. Eur J Immunol (2007) 2.43
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol (2007) 2.38
IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest (2007) 2.37
Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. Cytokine (2007) 2.33
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A (2007) 2.27
Tumors and inflammatory infiltrates: friends or foes? Clin Exp Metastasis (2002) 2.08
Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol (2008) 1.59
First steps of tumor-related angiogenesis. Lab Invest (1991) 1.48
Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. J Cereb Blood Flow Metab (1999) 1.35
Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases. J Cell Biochem (2000) 1.33
Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. J Biol Chem (2003) 1.32
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc Res (2000) 1.31
Different pathways of macromolecule extravasation from hyperpermeable tumor vessels. Microvasc Res (2000) 1.16
Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium. Am J Pathol (1997) 1.12
Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stress. Am J Physiol (1997) 1.09
New insight into CCN3 interactions--nuclear CCN3 : fact or fantasy? Cell Commun Signal (2006) 1.02
Isolation and longterm culture of human intestinal microvascular endothelial cells. Gut (1995) 1.02
Histone acetylases--versatile players. Genes Cells (2001) 0.95
Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol (2003) 2.72
Primary antitumor immune response mediated by CD4+ T cells. Immunity (2005) 2.72
Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol (2009) 2.40
Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood (2004) 1.61
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations. J Exp Med (2005) 1.54
Noninvasive assessment of myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy. Heart (2013) 1.51
Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab (2004) 1.51
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood (2004) 1.50
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nat Commun (2011) 1.49
The molecular basis for oat intolerance in patients with celiac disease. PLoS Med (2004) 1.40
[A patient with aortic stenosis and reduced left ventricular function]. Tidsskr Nor Laegeforen (2009) 1.39
[A 52-year old woman with fever and respiratory failure]. Tidsskr Nor Laegeforen (2009) 1.39
The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients. Am J Transplant (2002) 1.36
The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies. J Leukoc Biol (2009) 1.25
Small cell lung cancer in Norway. Should more patients have been offered surgical therapy? Eur J Cardiothorac Surg (2004) 1.23
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol (2010) 1.21
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol. J Immunol (2005) 1.20
Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet (2013) 1.11
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins. Arterioscler Thromb Vasc Biol (2008) 1.06
Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol (2007) 1.05
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ Res (2006) 1.03
Evaluation of disease activity in IBD at the time of diagnosis by the use of clinical, biochemical, and fecal markers. Scand J Gastroenterol (2011) 1.02
Genetic variability in BK Virus regulatory regions in urine and kidney biopsies from renal-transplant patients. J Med Virol (2006) 1.01
Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules. Blood (2005) 1.01
Treatment of polyomavirus infection with cidofovir in a renal-transplant recipient. Nephrol Dial Transplant (2002) 0.97
Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry. J Histochem Cytochem (2007) 0.95
Inflammatory rheumatic disease and smoking are predictors of aortic inflammation: a controlled study of biopsy specimens obtained at coronary artery surgery. Arthritis Rheum (2007) 0.95
Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. Am J Pathol (2002) 0.95
The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol (2012) 0.94
Kidney biopsies taken before and after oral sodium phosphate bowel cleansing. Nephrol Dial Transplant (2006) 0.94
Macrophage-derived IL-33 is a critical factor for placental growth. J Immunol (2013) 0.93
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arterioscler Thromb Vasc Biol (2012) 0.91
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix. Int J Cancer (2004) 0.90
Human papillomavirus (HPV)-positive tonsillar carcinomas are frequent and have a favourable prognosis in males in Norway. Acta Otolaryngol (2010) 0.90
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation. Eur Heart J (2005) 0.89
Transcription factor AP-2α promotes EGF-dependent invasion of human trophoblast. Endocrinology (2011) 0.89
Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts. Endocrinology (2013) 0.89
Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo. Blood (2004) 0.89
Associations between TS, TTF-1, FR-α, FPGS, and overall survival in patients with advanced non-small-cell lung cancer receiving pemetrexed plus carboplatin or gemcitabine plus carboplatin as first-line chemotherapy. J Thorac Oncol (2013) 0.89
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood (2009) 0.89
Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria. J Muscle Res Cell Motil (2008) 0.88
Kidneys from deceased donors more than 75 years perform acceptably after transplantation. Transplantation (2009) 0.88
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis. J Immunol (2013) 0.88
Three independent mechanisms for arrest in G2 after ionizing radiation. Cell Cycle (2011) 0.87
DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. Int J Oncol (2011) 0.87
Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells. Eur J Immunol (2014) 0.87
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies. J Biol Chem (2009) 0.86
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. J Immunol (2005) 0.86
Complement activation in early protocol kidney graft biopsies after living-donor transplantation. Transplantation (2003) 0.86
Endostatin suppresses IGF-II-mediated signaling and invasion of human extravillous trophoblasts. Endocrinology (2011) 0.85
Diagnostic accuracy of computed tomography and histopathology in the diagnosis of usual interstitial pneumonia. Acta Radiol (2012) 0.85
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology (2014) 0.84
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model. J Immunol (2008) 0.84
Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of Hsp70 by decreased mRNA stability. J Mol Med (Berl) (2005) 0.84
Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds. Arch Oral Biol (2009) 0.83
The HUVEC/Matrigel assay: an in vivo assay of human angiogenesis suitable for drug validation. Methods Mol Biol (2007) 0.82
The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propria. Inflamm Bowel Dis (2006) 0.82
Evaluation of human first trimester decidual and telomerase-transformed endometrial stromal cells as model systems of in vitro decidualization. Reprod Biol Endocrinol (2011) 0.82
European panel on the appropriateness of gastrointestinal endoscopy II guidelines help in selecting and prioritizing patients referred to colonoscopy--a quality control study. Scand J Gastroenterol (2014) 0.81
Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil. Anticancer Res (2008) 0.81
Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis. BMC Gastroenterol (2014) 0.80
Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women. J Soc Gynecol Investig (2003) 0.80
Generation and characterization of an immortalized human mesenchymal stromal cell line. Stem Cells Dev (2014) 0.80
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies. PLoS One (2012) 0.79
A class of DNA-binding peptides from wheat bud causes growth inhibition, G2 cell cycle arrest and apoptosis induction in HeLa cells. Mol Cancer (2009) 0.79
Cell proliferation and gill morphology in anoxic crucian carp. Am J Physiol Regul Integr Comp Physiol (2005) 0.79
CD38 is a marker of human lacteals. Virchows Arch (2002) 0.79
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies. Xenotransplantation (2002) 0.79
The MHC haplotype H2b converts two pure nonlupus mouse strains to producers of antinuclear antibodies. J Immunol (2009) 0.79
Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. Anticancer Res (2009) 0.79
Decreased endomyocardial RANKL expression in transplant coronary artery disease. Transplantation (2006) 0.78
AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans. Biol Reprod (2013) 0.78
Glutamine starvation of monocytes inhibits the ubiquitin-proteasome proteolytic pathway. Biochim Biophys Acta (2003) 0.77
Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas. Head Neck (2010) 0.77
Inflammation in Early Kidney Allograft Surveillance Biopsies With and Without Associated Tubulointerstitial Chronic Damage as a Predictor of Fibrosis Progression and Development of De Novo Donor Specific Antibodies. Transplantation (2017) 0.77
Cellular response to chemoradiotherapy, radiotherapy and chemotherapy in two colorectal cancer cell lines. Radiat Res (2009) 0.76
[Mutation testing for non-small-cell lung cancer]. Tidsskr Nor Laegeforen (2012) 0.76
Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation. Xenotransplantation (2006) 0.76
Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells. Transl Oncol (2009) 0.76
Investigations as a prerequisite for genetic counseling after termination of pregnancy based on sonographic detection of serious central nervous system--or skeletal anomalies. Acta Obstet Gynecol Scand (2008) 0.75
The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells. Anticancer Res (2004) 0.75
A cost comparison of telepathology and a visiting pathologist service. J Telemed Telecare (2003) 0.75
Autoimmune enteropathy in Swedish children, 1985-2002: a call for strict diagnostic criteria. Scand J Gastroenterol (2008) 0.75