Published in Drug Metab Dispos on September 17, 2008
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
What do drug transporters really do? Nat Rev Drug Discov (2014) 1.41
Quantifying mitochondrial and plasma membrane potentials in intact pulmonary arterial endothelial cells based on extracellular disposition of rhodamine dyes. Am J Physiol Lung Cell Mol Physiol (2011) 0.87
The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother (2012) 0.78
Stereoselective interaction of pantoprazole with ABCG2. II. In vitro flux analysis. Drug Metab Dispos (2012) 0.76
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest (1998) 3.66
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry (1998) 2.87
Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J (2005) 2.03
Multidrug resistance transporters and modulation. Curr Opin Oncol (2000) 1.71
The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int (2007) 1.68
Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res (2004) 1.35
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Res (2005) 1.33
Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells. J Acquir Immune Defic Syndr Hum Retrovirol (1998) 1.32
HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther (2004) 1.29
A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients. Clin Cancer Res (2007) 1.24
Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther (2002) 1.24
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Res (2006) 1.23
The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol (2005) 1.20
Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2. Biochim Biophys Acta (2002) 1.14
Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther (2006) 1.14
Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse. Drug Metab Dispos (2007) 1.09
Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier. Biochemistry (1997) 1.04
Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metab Dispos (2005) 1.01
Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat. J Pharm Sci (1987) 0.99
Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine. Drug Metab Dispos (2007) 0.97
Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. Drug Metab Dispos (2007) 0.94
Active transport of nitrofurantoin into human milk. Pharmacotherapy (2001) 0.93
Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. Bioorg Med Chem (2007) 0.93
Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos (2006) 0.89
A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors. Cancer Chemother Pharmacol (2004) 0.88
In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk. J Pharmacol Exp Ther (1988) 0.86
MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro. J Pediatr Surg (2002) 0.85
Active transport of nitrofurantoin across a mouse mammary epithelial monolayer. J Pharmacol Exp Ther (1997) 0.85
Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk. J Pharmacol Exp Ther (2001) 0.83
Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier. Antimicrob Agents Chemother (2005) 0.82
Active transport of nitrofurantoin into rat milk. Adv Exp Med Biol (2001) 0.80
Effect of altered serum protein binding on propranolol distribution into milk in the lactating rabbit. J Pharmacol Exp Ther (1988) 0.78
Pharmacokinetics of caffeine and its demethylated metabolites in lactating adult rabbits and neonatal offspring. Predictions of breast milk to serum concentration ratios. Drug Metab Dispos (1992) 0.77
Pharmacokinetics of acetaminophen, antipyrine, and salicylic acid in the lactating and nursing rabbit, with model predictions of milk to serum concentration ratios and neonatal dose. Toxicol Appl Pharmacol (1991) 0.77
Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobases. Pharm Res (2002) 0.76
Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med (2011) 2.80
Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry (2011) 2.71
Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell (2005) 1.82
Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery. J Control Release (2013) 1.77
Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther (2007) 1.64
Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology (2009) 1.61
Pharmacokinetics in the newborn. Adv Drug Deliv Rev (2003) 1.47
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Patent ductus arteriosus ligation and post-operative hemodynamic instability: case report and framework for enhanced neonatal care. Indian J Pediatr (2010) 1.44
Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet (2002) 1.42
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice. Cancer Res (2004) 1.41
Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart disease. Neonatology (2009) 1.39
Hazardous course of an end-tidal carbon dioxide catheter in a premature infant. Anesthesiology (2007) 1.37
Ontogeny of hepatic and renal systemic clearance pathways in infants: part II. Clin Pharmacokinet (2002) 1.28
Neonatologist-performed functional echocardiography in the neonatal intensive care unit. Semin Fetal Neonatal Med (2010) 1.26
Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia. J Biomed Nanotechnol (2009) 1.21
Core competencies for research training in the clinical pharmaceutical sciences. Am J Pharm Educ (2011) 1.21
Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. Am J Respir Crit Care Med (2003) 1.20
Evolution of ciprofloxacin-resistant Staphylococcus aureus in in vitro pharmacokinetic environments. Antimicrob Agents Chemother (2004) 1.17
Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm (2013) 1.17
Does echocardiography facilitate determination of hemodynamic significance attributable to the ductus arteriosus? Eur J Pediatr (2009) 1.16
Expanding the utility of the Biphasic Alcohol Effects Scale (BAES) and initial psychometric support for the Brief-BAES (B-BAES). Alcohol Clin Exp Res (2009) 1.15
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res (2007) 1.14
Tertiary-treated municipal wastewater is a significant point source of antibiotic resistance genes into Duluth-Superior Harbor. Environ Sci Technol (2011) 1.14
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol (2006) 1.11
Pharmacodynamic modeling of ciprofloxacin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (2005) 1.06
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. J Pediatr (2011) 1.05
Acute changes in myocardial systolic function in preterm infants undergoing patent ductus arteriosus ligation: a tissue Doppler and myocardial deformation study. J Am Soc Echocardiogr (2012) 1.04
Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers. Drug Metab Dispos (2010) 1.01
Intraurethral knot in a very-low-birth-weight infant: radiological recognition, surgical management and prevention. Pediatr Radiol (2005) 1.00
GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats. Antimicrob Agents Chemother (2002) 0.94
Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors. Invest Radiol (2008) 0.92
Enhanced intensive care for the neonatal ductus arteriosus. Acta Paediatr (2006) 0.92
Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants: optimization and in vitro characterization. AAPS J (2008) 0.92
Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism. Drug Metab Dispos (2011) 0.91
Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3. Arch Dis Child Fetal Neonatal Ed (2013) 0.90
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia. Pediatr Res (2010) 0.90
Cyclosporin A disposition following acute traumatic brain injury. J Neurotrauma (2006) 0.90
Oxygen attenuates atelectasis-induced injury in the in vivo rat lung. Anesthesiology (2005) 0.89
Using ontogeny information to build predictive models for drug elimination. Drug Discov Today (2008) 0.89
Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infants. Arch Dis Child Fetal Neonatal Ed (2010) 0.89
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (2005) 0.87
Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model. Anesth Analg (2006) 0.87
Haemodynamic changes after delivery room surfactant administration to very low birth weight infants. Arch Dis Child Fetal Neonatal Ed (2010) 0.87
Mechanism-based pharmacodynamic models of fluoroquinolone resistance in Staphylococcus aureus. Antimicrob Agents Chemother (2006) 0.87
Effects of a P-glycoprotein inhibitor on brain and plasma concentrations of anti-human immunodeficiency virus drugs administered in combination in rats. Drug Metab Dispos (2002) 0.87
Non-invasive cardiac output monitoring in neonates using bioreactance: a comparison with echocardiography. Neonatology (2012) 0.87
A pea chloroplast translation elongation factor that is regulated by abiotic factors. Biochem Biophys Res Commun (2004) 0.86
Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement. JAMA (2006) 0.86
Vasopressin as a rescue therapy for refractory pulmonary hypertension in neonates: case series. Pediatr Crit Care Med (2014) 0.86
Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression. Mol Pharmacol (2007) 0.85
Duodenal and biliary atresia associated with facial, thyroid and auditory apparatus abnormalities: a new mandibulofacial dysostosis syndrome? Clin Dysmorphol (2006) 0.85
Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury. J Neurotrauma (2010) 0.84
Indomethacin impairs coronary perfusion in infants with hemodynamically significant ductus arteriosus. Neonatology (2011) 0.84
Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α. Am J Physiol Lung Cell Mol Physiol (2012) 0.84
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. Am J Physiol Heart Circ Physiol (2010) 0.84
Acyclovir, ganciclovir, and zidovudine transfer into rat milk. Antimicrob Agents Chemother (2002) 0.83
Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients. Cancer Chemother Pharmacol (2013) 0.83
The use of targeted neonatal echocardiography to confirm placement of peripherally inserted central catheters in neonates. Am J Perinatol (2011) 0.83
Coronary artery perfusion and myocardial performance after patent ductus arteriosus ligation. J Thorac Cardiovasc Surg (2011) 0.82
Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity. Drug Metab Dispos (2007) 0.82
Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release. AAPS J (2009) 0.82
Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in Ontario. Paediatr Child Health (2011) 0.82
PDA ligation and health outcomes: a meta-analysis. Pediatrics (2014) 0.82
Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier. Antimicrob Agents Chemother (2005) 0.82
Adrenal function in preterm infants undergoing patent ductus arteriosus ligation. Neonatology (2013) 0.82
Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme. J Pharmacol Exp Ther (2012) 0.82
Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 0.82
Ligation of the patent ductus arteriosus in preterm infants: understanding the physiology. J Pediatr (2013) 0.81
Surfactant and patent ductus arteriosus. Indian J Pediatr (2010) 0.81
Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats. Free Radic Biol Med (2010) 0.81
Bioavailability and pharmacokinetics of intranasal hydromorphone in patients experiencing vasomotor rhinitis. Clin Drug Investig (2004) 0.80
High payload dual therapeutic-imaging nanocarriers for triggered tumor delivery. Small (2012) 0.80
The ductus arteriosus: a refined approach! Semin Perinatol (2012) 0.80
Is routine preoperative 2-dimensional echocardiography necessary for infants with esophageal atresia, omphalocele, or anorectal malformations? J Pediatr Surg (2010) 0.80
Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues. PLoS One (2012) 0.80
Abundance and diversity of organohalide-respiring bacteria in lake sediments across a geographical sulfur gradient. FEMS Microbiol Ecol (2013) 0.80
Effect of fluticasone propionate nasal spray on bioavailability of intranasal hydromorphone hydrochloride in patients with allergic rhinitis. Pharmacotherapy (2004) 0.80
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. J Nat Prod (2015) 0.80
Factors affecting the in vivo lactone stability and systemic clearance of the lipophilic camptothecin analogue AR-67. Pharm Res (2010) 0.80
A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies. Clin Cancer Res (2010) 0.80
Reducing signs of aging and increasing lifespan by drug synergy. Aging Cell (2013) 0.80
Basolateral active uptake of nitrofurantoin in the CIT3 cell culture model of lactation. Drug Metab Dispos (2003) 0.80
Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat. J Biochem Mol Toxicol (2007) 0.80
Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1. J Antibiot (Tokyo) (2012) 0.79
Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation. Am J Respir Cell Mol Biol (2014) 0.79
Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats. Drug Metab Dispos (2006) 0.79
Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support. AMIA Jt Summits Transl Sci Proc (2013) 0.79
Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. Am J Physiol Heart Circ Physiol (2012) 0.79
Cardiovascular support in preterm infants: a survey of practices in Australia and New Zealand. J Paediatr Child Health (2011) 0.78
Non-invasive cardiac output monitoring in preterm infants undergoing patent ductus arteriosus ligation: a comparison with echocardiography. Neonatology (2014) 0.78
Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose. J Nat Prod (2012) 0.78
Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Stereoselective interaction of pantoprazole with ABCG2. I. Drug accumulation in rat milk. Drug Metab Dispos (2012) 0.78
Caution with prolonged or high-dose infusions of catecholamines in premature infants. Acta Paediatr (2005) 0.78
The impact of amplitude-integrated electroencephalography on NICU practice. Can J Neurol Sci (2012) 0.78
The patent ductus arteriosus ligation decision. J Pediatr (2011) 0.77
Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition. Toxicon (2009) 0.77