Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.

PubWeight™: 1.26‹?› | Rank: Top 10%

🔗 View Article (PMC 2612039)

Published in Brain Res Bull on September 24, 2008

Authors

Olga A Timofeeva1, David Sanders, Kristen Seemann, Liwei Yang, Daniel Hermanson, Sam Regenbogen, Samantha Agoos, Anita Kallepalli, Anit Rastogi, David Braddy, Corinne Wells, Charles Perraut, Frederic J Seidler, Theodore A Slotkin, Edward D Levin

Author Affiliations

1: Department of Psychiatry and Behavioral Sciences, Box #3412, Duke University Medical Center, Durham, NC 27710, USA. timofeev@duke.edu

Articles citing this

Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev (2012) 6.12

Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect (2010) 2.46

Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics (2010) 2.35

Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Environ Health Perspect (2009) 1.56

Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol (2009) 1.44

Neurobehavioral and neurodevelopmental effects of pesticide exposures. Neurotoxicology (2012) 1.25

Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Environ Health Perspect (2008) 1.19

Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies. J Toxicol Environ Health B Crit Rev (2013) 1.12

Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav Brain Res (2009) 1.08

Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. Brain Res Bull (2008) 0.99

Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicol Teratol (2011) 0.97

Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. Brain Res Bull (2010) 0.96

Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environ Health Perspect (2010) 0.95

Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats. Toxicol Sci (2009) 0.87

Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci (2011) 0.86

Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. Toxicol Sci (2013) 0.80

Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. Neurotoxicol Teratol (2015) 0.80

Cellular localization of dieldrin and structure-activity relationship of dieldrin analogues in dopaminergic cells. Chem Res Toxicol (2013) 0.79

Genetic aspects of behavioral neurotoxicology. Neurotoxicology (2009) 0.79

Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicol Teratol (2009) 0.79

Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol (2012) 0.78

Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. Brain Res Bull (2015) 0.78

The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas. Environ Health (2010) 0.77

Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition. Neurotoxicology (2013) 0.77

Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. PLoS One (2015) 0.77

Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity. Neurotoxicology (2014) 0.77

Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior. Toxicol Sci (2013) 0.76

Cytogenetic evaluation of malathion-induced toxicity in Sprague-Dawley rats. Mutat Res (2011) 0.75

Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull (2017) 0.75

Articles cited by this

Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) (2001) 4.03

Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol (2000) 3.03

Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem Res Toxicol (2004) 2.67

Developmental neurotoxicity of chlorpyrifos: cellular mechanisms. Toxicol Appl Pharmacol (1995) 2.47

Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect (2004) 2.25

Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Res Dev Brain Res (2001) 1.90

Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect (2005) 1.79

Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res Bull (2007) 1.72

Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol (2002) 1.72

Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect (2006) 1.69

The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology (Berl) (1988) 1.63

Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport (1997) 1.45

Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect (2006) 1.42

Organophosphorus ester-induced delayed neurotoxicity. Annu Rev Pharmacol Toxicol (1981) 1.39

Morphogenetic roles of acetylcholine. Environ Health Perspect (1999) 1.39

Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol (2007) 1.36

Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ Health Perspect (2007) 1.32

Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Res Bull (2007) 1.32

Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol (2004) 1.27

Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Res Dev Brain Res (2005) 1.24

Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists. J Neurosci (2000) 1.24

A sensitive open field measure of anxiolytic drug activity. Pharmacol Biochem Behav (1981) 1.23

Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ Health Perspect (2008) 1.22

Anxiogenic action of caffeine: an experimental study in rats. J Psychopharmacol (1997) 1.13

NMDA receptors and learning and memory processes. Curr Drug Targets (2001) 1.10

Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ Health Perspect (2008) 1.09

Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Res Bull (2007) 1.04

Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environ Health Perspect (2008) 1.00

Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicol Teratol (2008) 0.99

A morphogenetic role for acetylcholine in mouse cerebral neocortex. Neurosci Biobehav Rev (2003) 0.98

Role of the central benzodiazepine receptor system in behavioral habituation to novelty. Behav Neurosci (1989) 0.94

Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol Teratol (2007) 0.91

Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicks. Arch Toxicol (1994) 0.89

Articles by these authors

Achieving child survival goals: potential contribution of community health workers. Lancet (2007) 14.72

The health and health system of South Africa: historical roots of current public health challenges. Lancet (2009) 7.76

WHO guidelines for management of severe malnutrition in rural South African hospitals: effect on case fatality and the influence of operational factors. Lancet (2004) 4.29

Task shifting: the answer to the human resources crisis in Africa? Hum Resour Health (2009) 4.00

Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) (2006) 3.68

Achieving the health Millennium Development Goals for South Africa: challenges and priorities. Lancet (2009) 3.35

Exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa (PROMISE-EBF): a cluster-randomised trial. Lancet (2011) 3.21

Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am (2008) 3.01

Setting priorities in child health research investments for South Africa. PLoS Med (2007) 2.93

Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Brain (2003) 2.41

The public health workforce in sub-Saharan Africa: challenges and opportunities. Ethn Dis (2003) 2.40

The Joint Action and learning initiative: towards a global agreement on national and global responsibilities for health. PLoS Med (2011) 2.33

The role of health extension workers in improving utilization of maternal health services in rural areas in Ethiopia: a cross sectional study. BMC Health Serv Res (2012) 2.33

Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect (2004) 2.25

Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. Psychopharmacology (Berl) (2009) 2.06

Open reduction and internal fixation compared with ORIF and primary subtalar arthrodesis for treatment of Sanders type IV calcaneal fractures: a randomized multicenter trial. J Orthop Trauma (2014) 2.04

Transfusion trigger trial for functional outcomes in cardiovascular patients undergoing surgical hip fracture repair (FOCUS). Transfusion (2006) 1.91

The toxicology of climate change: environmental contaminants in a warming world. Environ Int (2009) 1.82

Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect (2005) 1.79

Pushing the international health research agenda towards equity and effectiveness. Lancet (2004) 1.74

Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients (2013) 1.74

Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacol Biochem Behav (2009) 1.74

Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl Acad Sci U S A (2012) 1.72

Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res Bull (2007) 1.72

Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol (2002) 1.72

Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatr (2008) 1.70

Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect (2006) 1.69

Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicol Appl Pharmacol (2011) 1.63

Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect (2003) 1.62

Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates. Neurotoxicol Teratol (2007) 1.56

Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Environ Health Perspect (2009) 1.56

Interviewing when family members are present. Am Fam Physician (2002) 1.56

Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention. Neuropsychopharmacology (2007) 1.54

Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ Health Perspect (2005) 1.53

Excellent can be the enemy of good: the case of diarrhoea management. Lancet (2013) 1.52

Coprescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. Headache (2003) 1.49

Global Equity Gauge Alliance: reflections on early experiences. J Health Popul Nutr (2003) 1.48

Health-systems strengthening: current and future activities. Lancet (2011) 1.45

Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ Health Perspect (2003) 1.44

Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol (2009) 1.44

Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol Appl Pharmacol (2004) 1.43

Current thinking about acute compartment syndrome of the lower extremity. Can J Surg (2010) 1.43

Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. Environ Health Perspect (2007) 1.43

Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect (2006) 1.42

What is the way forward for health in Zimbabwe? Lancet (2009) 1.42

Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? Environ Health Perspect (2002) 1.41

WHO guidelines for severe malnutrition: are they feasible in rural African hospitals? Arch Dis Child (2006) 1.40

A policy review of the community health worker programme in Iran. J Public Health Policy (2011) 1.39

An open letter to the Executive Board of WHO. Lancet (2002) 1.39

Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ Health Perspect (2006) 1.37

Improving the hospital management of malnourished children by participatory research. Int J Qual Health Care (2004) 1.37

Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): study rationale and design. BMC Musculoskelet Disord (2008) 1.36

Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol (2007) 1.36

Lay health worker attrition: important but often ignored. Bull World Health Organ (2011) 1.34

Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Brain Res Dev Brain Res (2003) 1.34

An effectiveness study of an integrated, community-based package for maternal, newborn, child and HIV care in South Africa: study protocol for a randomized controlled trial. Trials (2011) 1.33

Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ Health Perspect (2007) 1.32

Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Res Bull (2007) 1.32

Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. Neuropsychopharmacology (2006) 1.31

Vaccination coverage and timeliness in three South African areas: a prospective study. BMC Public Health (2011) 1.30

The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Brain Res Dev Brain Res (2005) 1.29

Community health workers' perspectives on their contribution to rural health and well-being in Iran. Am J Public Health (2011) 1.29

Building capacity without disrupting health services: public health education for Africa through distance learning. Hum Resour Health (2009) 1.28

Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol (2004) 1.27

Critical review: nicotine for the fetus, the infant and the adolescent? J Health Psychol (2007) 1.26

Implications of the new WHO guidelines on HIV and infant feeding for child survival in South Africa. Bull World Health Organ (2010) 1.26

Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine. Crit Rev Toxicol (2006) 1.25

Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Res Dev Brain Res (2005) 1.24

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. J Pharmacol Exp Ther (2009) 1.24

Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models. Alcohol Clin Exp Res (2005) 1.24

Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ Health Perspect (2008) 1.22

Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect (2004) 1.20

Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats. Psychopharmacology (Berl) (2010) 1.20

The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiol Behav (2008) 1.20