Engineering viable foot-and-mouth disease viruses with increased thermostability as a step in the development of improved vaccines.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 2593342)

Published in J Virol on October 01, 2008

Authors

Roberto Mateo1, Eva Luna, Verónica Rincón, Mauricio G Mateu

Author Affiliations

1: Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Articles citing this

Viral quasispecies evolution. Microbiol Mol Biol Rev (2012) 2.69

A Prime-Boost Vaccination Strategy in Cattle to Prevent Foot-and-Mouth Disease Using a "Single-Cycle" Alphavirus Vector and Empty Capsid Particles. PLoS One (2016) 2.03

Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS Pathog (2013) 1.18

Viral genome segmentation can result from a trade-off between genetic content and particle stability. PLoS Genet (2011) 1.03

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Nat Struct Mol Biol (2015) 0.97

Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions. Proc Natl Acad Sci U S A (2013) 0.94

Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Mol Pharmacol (2011) 0.89

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition. J Virol (2010) 0.88

Evaluation of a genetically modified foot-and-mouth disease virus vaccine candidate generated by reverse genetics. BMC Vet Res (2012) 0.87

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid resistance. J Virol (2010) 0.87

Requirements for improved vaccines against foot-and-mouth disease epidemics. Clin Exp Vaccine Res (2013) 0.86

Exploring the Balance between DNA Pressure and Capsid Stability in Herpesviruses and Phages. J Virol (2015) 0.82

The pH Stability of Foot-and-Mouth Disease Virus Particles Is Modulated by Residues Located at the Pentameric Interface and in the N Terminus of VP1. J Virol (2015) 0.82

Systematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region. J Virol (2009) 0.82

Interferon-γ induced by in vitro re-stimulation of CD4+ T-cells correlates with in vivo FMD vaccine induced protection of cattle against disease and persistent infection. PLoS One (2012) 0.81

Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues affecting virus stability. PLoS One (2013) 0.81

Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles. J Virol (2015) 0.80

An increase in acid resistance of foot-and-mouth disease virus capsid is mediated by a tyrosine replacement of the VP2 histidine previously associated with VP0 cleavage. J Virol (2013) 0.77

Truncated Bovine Integrin Alpha-v/Beta-6 as a Universal Capture Ligand for FMD Diagnosis. PLoS One (2016) 0.75

SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability. J Virol (2017) 0.75

Equine Rhinitis A Virus Mutants with Altered Acid Resistance Unveil a Key Role of VP3 and Intrasubunit Interactions in the Control of the pH Stability of the Aphthovirus Capsid. J Virol (2016) 0.75

Articles cited by this

RASMOL: biomolecular graphics for all. Trends Biochem Sci (1995) 33.76

WHAT IF: a molecular modeling and drug design program. J Mol Graph (1990) 24.35

The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution. Nature (1989) 5.87

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. J Mol Biol (1995) 3.76

Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology (1983) 3.04

Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001. Rev Sci Tech (2002) 2.76

To build a virus capsid. An equilibrium model of the self assembly of polyhedral protein complexes. J Mol Biol (1994) 2.64

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. EMBO J (1999) 2.28

Antibody recognition of picornaviruses and escape from neutralization: a structural view. Virus Res (1995) 2.13

Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination. J Virol (1987) 2.02

Intercapsomeric disulfide bonds in papillomavirus assembly and disassembly. J Virol (1998) 1.85

The structure and antigenicity of a type C foot-and-mouth disease virus. Structure (1994) 1.82

Rational engineering of enzyme stability. J Biotechnol (2004) 1.70

On the role of electrostatic interactions in the design of protein-protein interfaces. J Mol Biol (2002) 1.65

Protein stabilization by salt bridges: concepts, experimental approaches and clarification of some misunderstandings. J Mol Recognit (2004) 1.61

Application of agar-gel diffusion analysis to a study of the antigenic structure of inactivated vaccines prepared from the virus of foot-and-mouth disease. J Immunol (1959) 1.53

Control and eradication of foot-and-mouth disease. Virus Res (2003) 1.53

Multiple virulence determinants of foot-and-mouth disease virus in cell culture. J Virol (1998) 1.52

Disulfide by Design: a computational method for the rational design of disulfide bonds in proteins. Bioinformatics (2003) 1.47

An engineered intersubunit disulfide enhances the stability and DNA binding of the N-terminal domain of lambda repressor. Biochemistry (1986) 1.37

Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid. Proc Natl Acad Sci U S A (2004) 1.36

Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture. J Virol (1990) 1.35

MODIP revisited: re-evaluation and refinement of an automated procedure for modeling of disulfide bonds in proteins. Protein Eng (2003) 1.33

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus. J Virol (1997) 1.29

Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids. J Virol (1995) 1.27

Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure (1996) 1.24

Synthesis of foot-and-mouth disease virus capsid proteins in insect cells using baculovirus expression vectors. J Gen Virol (1990) 1.23

Comparison of the antibodies elicited by the individual structural polypeptides of foot-and mouth disease and polio viruses. J Gen Virol (1979) 1.22

Development of novel strategies to control foot-and-mouth disease: marker vaccines and antivirals. Biologicals (2005) 1.16

Assembly of foot-and-mouth disease virus empty capsids synthesized by a vaccinia virus expression system. J Gen Virol (1995) 1.11

Cys residues of the hepatitis B virus capsid protein are not essential for the assembly of viral core particles but can influence their stability. J Virol (1992) 1.08

Expression of foot-and-mouth disease virus capsid proteins in silkworm-baculovirus expression system and its utilization as a subunit vaccine. PLoS One (2008) 1.07

Thermal stabilization of thymidylate synthase by engineering two disulfide bridges across the dimer interface. J Mol Biol (1994) 1.05

Expression, processing, and assembly of foot-and-mouth disease virus capsid structures in heterologous systems: induction of a neutralizing antibody response in guinea pigs. J Virol (1991) 1.04

Engineering thermal stability in RNA phage capsids via disulphide bonds. J Nanosci Nanotechnol (2005) 0.99

Salt-bridges can stabilize but do not accelerate the folding of the homodimeric coiled-coil peptide GCN4-p1. J Mol Biol (2004) 0.93

Deterministic, compensatory mutational events in the capsid of foot-and-mouth disease virus in response to the introduction of mutations found in viruses from persistent infections. J Virol (2006) 0.93

Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function. J Biol Chem (2003) 0.93

Introduction and history of foot-and-mouth disease virus. Curr Top Microbiol Immunol (2005) 0.91

Thermostable variants are not generally represented in foot-and-mouth disease virus quasispecies. J Gen Virol (2007) 0.88

Engineering better vaccines for foot-and-mouth disease. Dev Biol (Basel) (2003) 0.85

Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis. Arch Biochem Biophys (2002) 0.82

Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins. Nat Biotechnol (1997) 0.81

ANTIBODY RESPONSE TO THE NONINFECTIOUS 7 MU COMPONENT OF THE VIRUS OF FOOT-AND-MOUTH DISEASE. Virology (1965) 0.78

Challenges and opportunities in developing and marketing vaccines for OIE List A and emerging animal diseases. Dev Biol (Basel) (2003) 0.77

Articles by these authors

Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid. Proc Natl Acad Sci U S A (2004) 1.36

Effect of macromolecular crowding agents on human immunodeficiency virus type 1 capsid protein assembly in vitro. J Virol (2005) 1.32

Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein. Biophys J (2007) 1.29

Thermodynamic dissection of a low affinity protein-protein interface involved in human immunodeficiency virus assembly. J Biol Chem (2003) 1.22

Manipulation of the mechanical properties of a virus by protein engineering. Proc Natl Acad Sci U S A (2008) 1.17

Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants. J Mol Biol (2007) 1.17

High mutant frequency in populations of a DNA virus allows evasion from antibody therapy in an immunodeficient host. J Virol (2003) 1.14

In vitro disassembly of a parvovirus capsid and effect on capsid stability of heterologous peptide insertions in surface loops. J Biol Chem (2003) 1.08

Electrostatic repulsion, compensatory mutations, and long-range non-additive effects at the dimerization interface of the HIV capsid protein. J Mol Biol (2005) 1.03

Nuclear transport of trimeric assembly intermediates exerts a morphogenetic control on the icosahedral parvovirus capsid. J Mol Biol (2006) 0.97

Functional relevance of amino acid residues involved in interactions with ordered nucleic acid in a spherical virus. J Biol Chem (2005) 0.95

The isolated C-terminal domain of Ring1B is a dimer made of stable, well-structured monomers. Biochemistry (2007) 0.95

Deterministic, compensatory mutational events in the capsid of foot-and-mouth disease virus in response to the introduction of mutations found in viruses from persistent infections. J Virol (2006) 0.93

Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function. J Biol Chem (2003) 0.93

The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization. Protein Sci (2004) 0.92

Mechanical elasticity as a physical signature of conformational dynamics in a virus particle. Proc Natl Acad Sci U S A (2012) 0.91

Resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy. PLoS One (2012) 0.91

Molecular recognition in the human immunodeficiency virus capsid and antiviral design. Virus Res (2012) 0.90

An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein. Protein Sci (2005) 0.89

Mechanical disassembly of single virus particles reveals kinetic intermediates predicted by theory. Biophys J (2012) 0.88

Thermostable variants are not generally represented in foot-and-mouth disease virus quasispecies. J Gen Virol (2007) 0.88

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition. J Virol (2010) 0.88

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid resistance. J Virol (2010) 0.87

A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53. Angew Chem Int Ed Engl (2004) 0.85

Structural mobility of the monomeric C-terminal domain of the HIV-1 capsid protein. FEBS J (2008) 0.85

Thermodynamic stability of a cold-adapted protein, type III antifreeze protein, and energetic contribution of salt bridges. Protein Sci (2006) 0.85

Structural tolerance versus functional intolerance to mutation of hydrophobic core residues surrounding cavities in a parvovirus capsid. J Mol Biol (2006) 0.84

Effects of macromolecular crowding on the inhibition of virus assembly and virus-cell receptor recognition. Biophys J (2011) 0.84

A slender tract of glycine residues is required for translocation of the VP2 protein N-terminal domain through the parvovirus MVM capsid channel to initiate infection. Biochem J (2013) 0.83

Molecular determinants of self-association and rearrangement of a trimeric intermediate during the assembly of a parvovirus capsid. J Mol Biol (2011) 0.83

Systematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region. J Virol (2009) 0.82

Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibody. J Virol (2007) 0.82

Dendrimers as potential inhibitors of the dimerization of the capsid protein of HIV-1. Biomacromolecules (2010) 0.81

Phage phi29 DNA replication organizer membrane protein p16.7 contains a coiled coil and a dimeric, homeodomain-related, functional domain. J Biol Chem (2004) 0.81

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity. PLoS One (2011) 0.81

Association equilibrium of the HIV-1 capsid protein in a crowded medium reveals that hexamerization during capsid assembly requires a functional C-domain dimerization interface. Biophys J (2013) 0.80

Quantitatively probing propensity for structural transitions in engineered virus nanoparticles by single-molecule mechanical analysis. Nanoscale (2015) 0.78

Envelope lipids regulate the in vitro assembly of the HIV-1 capsid. Biophys J (2007) 0.78

Larger helical populations in peptides derived from the dimerization helix of the capsid protein of HIV-1 results in peptide binding toward regions other than the "hotspot" interface. Biomacromolecules (2011) 0.77

Quantification and modification of the equilibrium dynamics and mechanics of a viral capsid lattice self-assembled as a protein nanocoating. Nanoscale (2015) 0.76

Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages. J Trop Med (2012) 0.75

Mechanical properties of viruses. Subcell Biochem (2013) 0.75

Structural virology. Preface. Subcell Biochem (2013) 0.75