PubRank

Joseph E Wedekind

Author PubWeight™ 41.13‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem 2006 1.75
2 The structural basis for recognition of the PreQ0 metabolite by an unusually small riboswitch aptamer domain. J Biol Chem 2009 1.47
3 Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer. Biochemistry 2006 1.41
4 A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization. RNA 2007 1.27
5 The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Proc Natl Acad Sci U S A 2004 1.24
6 APOBEC3G subunits self-associate via the C-terminal deaminase domain. J Biol Chem 2008 1.24
7 Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. J Biol Chem 2008 1.23
8 Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation. J Am Chem Soc 2009 1.20
9 Riboswitch structure in the ligand-free state. Wiley Interdiscip Rev RNA 2011 1.17
10 Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation. J Biol Chem 2011 1.14
11 Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding. J Biol Chem 2007 1.13
12 Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn. Biochemistry 2005 1.06
13 Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold. Nat Chem Biol 2013 1.03
14 A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function. Biochemistry 2009 1.01
15 Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme. RNA 2008 1.00
16 Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic Acids Res 2013 0.98
17 Identification of an imino group indispensable for cleavage by a small ribozyme. J Am Chem Soc 2009 0.97
18 Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. Biochemistry 2004 0.96
19 Core-binding factor β increases the affinity between human Cullin 5 and HIV-1 Vif within an E3 ligase complex. Biochemistry 2012 0.95
20 A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr D Biol Crystallogr 2007 0.94
21 APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Biochem Biophys Res Commun 2006 0.94
22 Molecular mechanism of preQ1 riboswitch action: a molecular dynamics study. J Phys Chem B 2012 0.90
23 Crystallization and X-ray diffraction analysis of an all-RNA U39C mutant of the minimal hairpin ribozyme. Acta Crystallogr D Biol Crystallogr 2002 0.90
24 Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate. Biochemistry 2005 0.90
25 Structural phylogenetic analysis of activation-induced deaminase function. J Immunol 2006 0.89
26 A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis. J Am Chem Soc 2012 0.88
27 Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme. Biochem Biophys Res Commun 2008 0.87
28 Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry 2009 0.85
29 Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path. J Am Chem Soc 2014 0.84
30 Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex. Structure 2012 0.84
31 Base ionization and ligand binding: how small ribozymes and riboswitches gain a foothold in a protein world. Curr Opin Struct Biol 2011 0.84
32 Structural characterization of nitrosomonas europaea cytochrome c-552 variants with marked differences in electronic structure. Chembiochem 2013 0.84
33 Exploring ribozyme conformational changes with X-ray crystallography. Methods 2009 0.83
34 Functional characterization of APOBEC-1 complementation factor phosphorylation sites. Biochim Biophys Acta 2006 0.82
35 Coupling of MBP fusion protein cleavage with sparse matrix crystallization screens to overcome problematic protein solubility. Biotechniques 2005 0.79
36 Crystallographic analysis of small ribozymes and riboswitches. Methods Mol Biol 2012 0.79
37 Crystallization and X-ray diffraction analysis of the Trp/amber editing site of hepatitis delta virus (+)RNA: a case of rational design. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.78
38 Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida. Acta Crystallogr D Biol Crystallogr 2004 0.77
39 Activation induced deaminase: the importance of being specific. Trends Genet 2004 0.77
40 Crystallographic analysis of the NNA7 Fab and proposal for the mode of human blood-group recognition. Acta Crystallogr D Biol Crystallogr 2005 0.76
41 Efficient syntheses of 5'-deoxy-5'-fluoroguanosine and -inosine. J Org Chem 2007 0.75
42 Purification, crystallization and X-ray diffraction analysis of a recombinant Fab that recognizes a human blood-group antigen. Acta Crystallogr D Biol Crystallogr 2004 0.75