Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome.

PubWeight™: 3.48‹?› | Rank: Top 1%

🔗 View Article (PMID 1884900)

Published in Diabetologia on June 01, 1991

Authors

E Ferrannini1, S M Haffner, B D Mitchell, M P Stern

Author Affiliations

1: Department of Medicine, University of Texas Health Science Center, San Antonio.

Associated clinical trials:

Diabetes and Cardiovascular Risk In Mexico City (San Antonio Heart Study) | NCT00005146

Treatment of Insulin Resistance in Hypertensive, Obese Adolescents | NCT00185705

Articles citing this

The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med (2003) 10.84

Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest (1995) 3.44

Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest (1993) 1.75

Insulin and gall stones: a population case control study in southern Italy. Gut (2000) 1.60

Obesity and metabolic syndrome and functional and structural brain impairments in adolescence. Pediatrics (2012) 1.55

Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Genet (1997) 1.42

Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med (2013) 1.37

Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS). Am Heart J (2008) 1.22

Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia (2005) 1.20

Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17

Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport. Am J Physiol Cell Physiol (2006) 1.15

Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. Int J Endocrinol (2013) 1.12

Elevated C-reactive protein levels and metabolic syndrome in the elderly: The role of central obesity data from the InChianti study. Atherosclerosis (2008) 1.12

Cardiovascular risk and insulin resistance in childhood cancer survivors. J Pediatr (2011) 1.11

Neuroinflammatory basis of metabolic syndrome. Mol Metab (2013) 1.10

Hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload. PLoS One (2008) 1.08

Relationships between inflammation, adiponectin, and oxidative stress in metabolic syndrome. PLoS One (2012) 1.08

Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab (2008) 1.04

Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus. J Clin Invest (1992) 1.04

Lifestyle modification in the management of the metabolic syndrome: achievements and challenges. Diabetes Metab Syndr Obes (2010) 1.03

Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the Seychelles. Cardiovasc Diabetol (2009) 1.03

Is metabolic syndrome a discrete entity in the general population? Evidence from the Caerphilly and Speedwell population studies. Heart (1998) 1.03

Insulin resistance. BMJ (1996) 1.00

Phenotypic, genetic, and genome-wide structure in the metabolic syndrome. BMC Genet (2003) 1.00

The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci (2008) 0.99

Metabolic syndrome and all-cause and cardiovascular mortality in an Italian elderly population: the Progetto Veneto Anziani (Pro.V.A.) Study. Diabetes Care (2008) 0.97

Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure. Mediators Inflamm (2009) 0.97

Obesity, metabolic syndrome, and insulin resistance in urban high school students of minority race/ethnicity. Arch Pediatr Adolesc Med (2012) 0.96

Plasma soluble gp130 levels are increased in older subjects with metabolic syndrome. The role of insulin resistance. Atherosclerosis (2010) 0.96

Weight change and incident metabolic syndrome in Iranian men and women; a 3 year follow-up study. BMC Public Health (2009) 0.94

The metabolically healthy but obese phenotype in African Americans. J Clin Hypertens (Greenwich) (2011) 0.93

Impact of the metabolic syndrome on the clinical outcome of patients with acute ST-elevation myocardial infarction. J Korean Med Sci (2010) 0.90

Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome. Front Biosci (Schol Ed) (2011) 0.89

Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study. Br Heart J (1994) 0.87

Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells. BMC Cell Biol (2008) 0.86

Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS One (2015) 0.86

Waist circumference and insulin resistance: a community based cross sectional study on reproductive aged Iranian women. Diabetol Metab Syndr (2011) 0.85

Factor analysis of metabolic syndrome components in the Coronary Artery Risk Development in Young Adults (CARDIA) study: examination of factors by race-sex groups and across time. Ann Epidemiol (2010) 0.85

Effects of combined exercise training on body composition and metabolic syndrome factors. Iran J Public Health (2012) 0.84

Genes and biochemical pathways in human skeletal muscle affecting resting energy expenditure and fuel partitioning. J Appl Physiol (1985) (2010) 0.84

Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study. Obesity (Silver Spring) (2014) 0.84

Tobacco and metabolic syndrome. Indian J Endocrinol Metab (2012) 0.83

The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. PLoS One (2008) 0.83

Cross-sectional study of diet, physical activity, television viewing and sleep duration in 233 110 adults from the UK Biobank; the behavioural phenotype of cardiovascular disease and type 2 diabetes. BMJ Open (2016) 0.83

Metabolic and cardiovascular complications in the liver transplant recipient. Ann Gastroenterol (2015) 0.82

Baseline levels, and changes over time in body mass index and fasting insulin, and their relationship to change in metabolic trait clustering. Metab Syndr Relat Disord (2014) 0.81

Chronic insulin treatment suppresses PTP1B function, induces increased PDGF signaling, and amplifies neointima formation in the balloon-injured rat artery. Am J Physiol Heart Circ Physiol (2008) 0.81

Prevalence of metabolic syndrome and related factors in bank employees according to different defining criteria, Vitória/ES, Brazil. Clinics (Sao Paulo) (2013) 0.81

Weight change over five-year periods and number of components of the metabolic syndrome in a Dutch cohort. Eur J Epidemiol (2010) 0.81

Evaluation of the Finnish Diabetes Risk Score (FINDRISC) as a screening tool for the metabolic syndrome. Rev Diabet Stud (2014) 0.80

Prognostic relations between inflammatory markers and mortality in diabetic patients with non-ST elevation acute coronary syndrome. Heart (2004) 0.80

Metabolic Risk Factors and Type 2 Diabetes Incidence in American Indian Children. J Clin Endocrinol Metab (2016) 0.80

Visceral adiposity syndrome. Diabetol Metab Syndr (2016) 0.79

The association among three aspects of physical fitness and metabolic syndrome in a Korean elderly population. Diabetol Metab Syndr (2015) 0.79

Fetal programming and early identification of newborns at high risk of free radical-mediated diseases. World J Clin Pediatr (2016) 0.78

Impaired glucose tolerance and unidentified diabetes. Postgrad Med J (1996) 0.78

Insulin resistance in Nigerians with essential hypertension. Afr Health Sci (2013) 0.78

Metabolic syndrome and risk factors for cardiovascular disease: are nonagenarians protected? Age (Dordr) (2009) 0.78

Metabolic syndrome and sleep apnea. Hippokratia (2008) 0.78

Association of the apolipoprotein b/apolipoprotein a-I ratio, metabolic syndrome components, total cholesterol, and low-density lipoprotein cholesterol with insulin resistance in the population of georgia. Int J Endocrinol (2014) 0.78

Incidence and risk factors of insulin resistance syndrome in 20-59 year-old Korean male workers. J Korean Med Sci (2007) 0.78

A Prelimenary Result of the Cardiovascular Risk factors Intervention Study (Pikom Study): Diabetes Mellitus, Hypertension and their Associated Factors. Malays J Med Sci (2005) 0.78

Prevalence of metabolic syndrome in patients with minor beta thalassemia and its related factors: a cross-sectional study. J Diabetes Metab Disord (2014) 0.78

Left ventricular hypertrophy and insulin resistance in adults from an urban community in The Gambia: cross-sectional study. PLoS One (2014) 0.77

Androgen deprivation therapy and cardiovascular disease: what is the linking mechanism? Ther Adv Urol (2015) 0.77

A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population. BMC Public Health (2015) 0.76

Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats. Anc Sci Life (2011) 0.76

Effects of water extracts of Graptopetalum paraguayense on blood pressure, fasting glucose, and lipid profiles of subjects with metabolic syndrome. Biomed Res Int (2013) 0.76

The Associations Between Helicobacter pylori Infection, Serum Vitamin D, and Metabolic Syndrome: A Community-Based Study. Medicine (Baltimore) (2016) 0.76

Diabetes in minorities: reflections on the medical dilemma and the healthcare crisis. Trans Am Clin Climatol Assoc (1996) 0.76

Long-term risk of acute coronary syndrome in splenectomized patients due to splenic injury. Medicine (Baltimore) (2015) 0.76

The effects of tai chi in centrally obese adults with depression symptoms. Evid Based Complement Alternat Med (2015) 0.76

The antioxidant status and concentrations of coenzyme Q10 and vitamin E in metabolic syndrome. ScientificWorldJournal (2013) 0.76

Prevalence of Metabolic Syndrome and its Related Risk Factors in the City of Oran, Algeria: the ISOR Study. Ethn Dis (2016) 0.75

Insulin resistance and vessel endothelial function. J R Soc Med (2002) 0.75

Prevalence of the metabolic syndrome in patients with carotid disease according to NHLBI/AHA and IDF criteria: a cross-sectional study. BMC Cardiovasc Disord (2012) 0.75

Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: project SuGAR. South Med J (2014) 0.75

Added value of different metabolic syndrome definitions for predicting cardiovascular disease and mortality events among elderly population: Tehran Lipid and Glucose Study. Eur J Clin Nutr (2014) 0.75

Triglycerides and disease. Postgrad Med J (1993) 0.75

Glycated Hemoglobin, Fasting Insulin and the Metabolic Syndrome in Males. Cross-Sectional Analyses of the Aragon Workers' Health Study Baseline. PLoS One (2015) 0.75

Of insulin resistance and normalcy. Diabetologia (1992) 0.75

Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients (2015) 0.75

Herbal Medicines for Treating Metabolic Syndrome: A Systematic Review of Randomized Controlled Trials. Evid Based Complement Alternat Med (2016) 0.75

Clinical impact of non-high density lipoprotein-cholesterol and apolipoprotein B on clinical outcomes in metabolic syndrome patients with acute myocardial infarction undergoing percutaneous coronary intervention. Korean Circ J (2012) 0.75

Prevalence of Metabolic Syndrome among Psychiatric Inpatients: A Hospital Based Study from Kashmir. J Clin Diagn Res (2017) 0.75

Vitamin D status is inversely associated with markers of risk for type 2 diabetes: A population based study in Victoria, Australia. PLoS One (2017) 0.75

Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study. Diabetol Metab Syndr (2017) 0.75

Association between fasting insulin and high-sensitivity C reactive protein in Korean adults. BMJ Open Sport Exerc Med (2017) 0.75

Articles by these authors

Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes (1997) 8.96

Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation (2000) 7.37

Community education for cardiovascular health. Lancet (1977) 6.32

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum (2001) 5.87

Effects of acculturation and socioeconomic status on obesity and diabetes in Mexican Americans. The San Antonio Heart Study. Am J Epidemiol (1988) 4.20

Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation (1996) 4.10

Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA (1990) 3.95

Prevalence of diabetes in Mexican Americans, Cubans, and Puerto Ricans from the Hispanic Health and Nutrition Examination Survey, 1982-1984. Diabetes Care (1991) 3.51

The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord (2001) 3.39

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet (1997) 3.37

Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study. Diabetes Care (1998) 3.34

Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes (1992) 3.27

The homeostasis model in the San Antonio Heart Study. Diabetes Care (1997) 2.92

Familial aggregation of age-related maculopathy. Am J Ophthalmol (1997) 2.77

A simple language-based acculturation scale for Mexican Americans: validation and application to health care research. Am J Public Health (1985) 2.71

Relationship of prevalence of non-insulin-dependent diabetes mellitus to Amerindian admixture in the Mexican Americans of San Antonio, Texas. Genet Epidemiol (1986) 2.71

Impact of diabetes on mortality after the first myocardial infarction. The FINMONICA Myocardial Infarction Register Study Group. Diabetes Care (1998) 2.70

Waist circumference as the best predictor of noninsulin dependent diabetes mellitus (NIDDM) compared to body mass index, waist/hip ratio and other anthropometric measurements in Mexican Americans--a 7-year prospective study. Obes Res (1997) 2.63

Birthweight and adult health outcomes in a biethnic population in the USA. Diabetologia (1994) 2.60

Rapid rise in the incidence of type 2 diabetes from 1987 to 1996: results from the San Antonio Heart Study. Arch Intern Med (1999) 2.58

Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA (1998) 2.56

Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel. J Intern Med (2006) 2.55

Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet (1999) 2.42

A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care (1996) 2.35

Lack of awareness and treatment of hyperlipidemia in type II diabetes in a community survey. JAMA (1989) 2.26

Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res (1996) 2.24

Sex difference in the effects of sociocultural status on diabetes and cardiovascular risk factors in Mexican Americans. The San Antonio Heart Study. Am J Epidemiol (1984) 2.16

Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes (1990) 2.15

The recent decline in ischemic heart disease mortality. Ann Intern Med (1979) 2.15

Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. Diabetes Care (2000) 2.14

Excess maternal transmission of type 2 diabetes. The Northern California Kaiser Permanente Diabetes Registry. Diabetes Care (1999) 2.11

Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes (1995) 2.09

Increased insulin concentrations in nondiabetic offspring of diabetic parents. N Engl J Med (1988) 2.06

Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic whites. San Antonio Heart Study. Am J Epidemiol (1990) 2.03

Role of insulin in endogenous hypertriglyceridemia. J Clin Invest (1967) 2.00

A quantitative scale of acanthosis nigricans. Diabetes Care (1999) 1.99

Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (1995) 1.99

Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study. Diabetologia (2009) 1.92

A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet (2001) 1.91

Affluence and cardiovascular risk factors in Mexican-Americans and other whites in three northern California communities. J Chronic Dis (1975) 1.89

Elevated incidence of type 2 diabetes in San Antonio, Texas, compared with that of Mexico City, Mexico. Diabetes Care (2001) 1.88

Prevalence, detection, and control of hypertension in a biethnic community. The San Antonio Heart Study. Am J Epidemiol (1985) 1.85

Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease. Arteriosclerosis (1986) 1.83

Special health problems of Mexican-Americans: obesity, gallbladder disease, diabetes mellitus, and cardiovascular disease. Adv Intern Med (1989) 1.82

Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland. Eur Heart J (1996) 1.82

Effects of socioeconomic status on hyperglycemia and retinopathy levels in Mexican Americans with NIDDM. Diabetes Care (1989) 1.81

Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. Diabetes (1984) 1.80

Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation (2000) 1.78

A comparison of three indicators for identifying Mexican Americans in epidemiologic research. Methodological findings from the San Antonio Heart Study. Am J Epidemiol (1986) 1.75

Diabetic retinopathy in Mexican Americans and non-Hispanic whites. Diabetes (1988) 1.72

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response. Clin Pharmacol Ther (2011) 1.69

The distribution of plasma lipoproteins in middle-aged male runners. Metabolism (1976) 1.69

Decreased prevalence of hypertension in Mexican-Americans. Hypertension (1990) 1.66

Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes (1997) 1.64

Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study. Kidney Int (2000) 1.62

Development of the multiple metabolic syndrome: an epidemiologic perspective. Epidemiol Rev (1998) 1.62

Excess incidence of treatment of end-stage renal disease in Mexican Americans. Am J Epidemiol (1988) 1.61

Genetic contributions to plasma total antioxidant activity. Arterioscler Thromb Vasc Biol (2001) 1.61

Genetics of atherosclerosis risk factors in Mexican Americans. Nutr Rev (1999) 1.61

Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS) Am J Clin Nutr (1997) 1.59

Clinical gallbladder disease in NIDDM subjects. Relationship to duration of diabetes and severity of glycemia. Diabetes Care (1993) 1.56

Serum leptin levels in Mexican Americans and non-Hispanic whites: association with body mass index and cigarette smoking. Ann Epidemiol (1997) 1.56

Ethnic differences in health knowledge and behaviors related to the prevention and treatment of coronary heart disease. The San Antonio Heart Study. Am J Epidemiol (1983) 1.55

Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study. Diabetes (1996) 1.53

Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med (1986) 1.53

Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Relation to plasma triglyceride and apolipoprotein B concentrations. Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Arterioscler Thromb Vasc Biol (1997) 1.53

Is there an excess in maternal transmission of NIDDM? Diabetologia (1995) 1.50

Does obesity explain excess prevalence of diabetes among Mexican Americans? Results of the San Antonio Heart Study. Diabetologia (1983) 1.48

Increased incidence of type II diabetes mellitus in Mexican Americans. Diabetes Care (1991) 1.45

Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study. Diabetes (1998) 1.45

Differential impact of insulin and obesity on cardiovascular risk factors in non-diabetic subjects. Int J Obes Relat Metab Disord (1996) 1.43

Accounting for relatedness in family based genetic association studies. Hum Hered (2007) 1.43