PubRank

Winfried Edelmann

Author PubWeight™ 93.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol 2005 2.71
2 Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev 2003 2.28
3 SLiCE: a novel bacterial cell extract-based DNA cloning method. Nucleic Acids Res 2012 2.17
4 Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A 2002 2.17
5 Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol 2004 2.16
6 Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A 2005 2.03
7 Mouse models of colon cancer. Gastroenterology 2009 1.98
8 Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 2007 1.96
9 Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol 2002 1.93
10 APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A 2002 1.89
11 Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell 2012 1.88
12 Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet 2005 1.84
13 An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res 2004 1.81
14 Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell 2004 1.81
15 Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A 2002 1.77
16 MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis. PLoS Genet 2008 1.76
17 Dietary induction of colonic tumors in a mouse model of sporadic colon cancer. Cancer Res 2008 1.58
18 Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis 2008 1.58
19 Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res 2008 1.52
20 Mouse models for human DNA mismatch-repair gene defects. Trends Mol Med 2002 1.49
21 Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 2006 1.49
22 Conditional inactivation of MLH1 in thymic and naive T-cells in mice leads to a limited incidence of lymphoblastic T-cell lymphomas. Leuk Lymphoma 2010 1.45
23 Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease. Hum Mol Genet 2002 1.44
24 Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching. J Immunol 2008 1.44
25 A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. Proc Natl Acad Sci U S A 2009 1.43
26 Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. J Exp Med 2004 1.41
27 Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J Cell Biol 2005 1.38
28 Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J Exp Med 2003 1.33
29 Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A 2008 1.32
30 MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. PLoS Genet 2009 1.22
31 Loss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer. Am J Med Genet C Semin Med Genet 2004 1.22
32 Mismatch repair proteins as sensors of alkylation DNA damage. Cancer Cell 2006 1.20
33 Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 2006 1.19
34 Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila) 2011 1.19
35 DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice. Am J Pathol 2002 1.12
36 An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology 2009 1.11
37 AIDing antibody diversity by error-prone mismatch repair. Semin Immunol 2012 1.10
38 PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proc Natl Acad Sci U S A 2010 1.08
39 Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway. Biol Reprod 2007 1.05
40 Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium. Oncogene 2002 1.04
41 The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity 2006 1.02
42 Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. J Clin Invest 2012 1.01
43 Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. Int J Cancer 2005 1.01
44 Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. J Immunol 2003 0.99
45 O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proc Natl Acad Sci U S A 2009 0.99
46 Involvement of Exo1b in DNA damage-induced apoptosis. Nucleic Acids Res 2009 0.98
47 Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 2003 0.98
48 DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2. J Biol Chem 2001 0.97
49 Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med 2012 0.95
50 Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A 2013 0.95
51 MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. PLoS One 2010 0.95
52 Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice. Glycobiology 2008 0.95
53 Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr 2008 0.94
54 Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A 2009 0.94
55 Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A 2008 0.94
56 A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Cancer Discov 2014 0.93
57 Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PLoS Genet 2008 0.91
58 A panel of repeat markers for detection of microsatellite instability in murine tumors. Mol Carcinog 2003 0.89
59 Cis lethal genetic interactions attenuate and alter p53 tumorigenesis. Proc Natl Acad Sci U S A 2010 0.88
60 DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts. J Invest Dermatol 2003 0.87
61 Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A 2008 0.87
62 Mismatch-mediated error prone repair at the immunoglobulin genes. Biomed Pharmacother 2011 0.86
63 Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice. J Neurosci Res 2005 0.85
64 Seamless Ligation Cloning Extract (SLiCE) cloning method. Methods Mol Biol 2014 0.84
65 Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas. Proc Natl Acad Sci U S A 2009 0.83
66 Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. Am J Pathol 2003 0.83
67 Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression. Dev Biol 2013 0.83
68 Analysis of meiotic prophase I in live mouse spermatocytes. Chromosome Res 2008 0.82
69 The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. J Exp Med 2012 0.81
70 Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis 2009 0.81
71 Msh6 protects mature B cells from lymphoma by preserving genomic stability. Am J Pathol 2010 0.80
72 Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice. Anticancer Res 2008 0.79
73 Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events. Nucleic Acids Res 2005 0.78
74 Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice. Anticancer Res 2003 0.76
75 Genes essential for cell viability that are linked to tumor suppressor genes play a role in cancer susceptibility. Cell Cycle 2010 0.75
76 Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer. Nutr Cancer 2012 0.75