Published in Chemistry on January 01, 2008
Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrob Agents Chemother (2010) 1.64
A submarine journey: the pyrrole-imidazole alkaloids. Mar Drugs (2009) 1.61
Small molecule control of bacterial biofilms. Org Biomol Chem (2012) 1.51
Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. J Med Chem (2009) 1.01
Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry (2012) 0.93
Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms. Org Biomol Chem (2011) 0.88
Biologically inspired strategies for combating bacterial biofilms. Curr Opin Pharmacol (2013) 0.86
Anti-biofilm compounds derived from marine sponges. Mar Drugs (2011) 0.84
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathog Dis (2014) 0.81
Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. Drug Chem Toxicol (2012) 0.81
Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Curr Drug Deliv (2015) 0.77
2-Aminopyrimidine as a novel scaffold for biofilm modulation. Org Biomol Chem (2012) 0.77
Expedient Synthesis of SMAMPs via Click Chemistry. ACS Med Chem Lett (2013) 0.76
Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii. Biomol NMR Assign (2012) 0.75
Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Des Devel Ther (2017) 0.75
Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Mol Microbiol (2017) 0.75
Anti-Biofilm Effect of Biodegradable Coatings Based on Hemibastadin Derivative in Marine Environment. Int J Mol Sci (2017) 0.75
Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity. Mar Drugs (2017) 0.75
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Inhibition of HIV fusion with multivalent gold nanoparticles. J Am Chem Soc (2008) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrob Agents Chemother (2010) 1.64
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Small molecule control of bacterial biofilms. Org Biomol Chem (2012) 1.51
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Controlling bacterial biofilms. Chembiochem (2009) 1.24
Combination approaches to combat multidrug-resistant bacteria. Trends Biotechnol (2013) 1.18
Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms. Chembiochem (2008) 1.15
Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus. Angew Chem Int Ed Engl (2012) 1.14
Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues. J Am Chem Soc (2007) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism. J Am Chem Soc (2009) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues. Org Biomol Chem (2008) 1.10
Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum. Angew Chem Int Ed Engl (2008) 1.09
A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms. Antimicrob Agents Chemother (2011) 1.08
Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae. ACS Med Chem Lett (2012) 1.04
Modulating the development of E. coli biofilms with 2-aminoimidazoles. Bioorg Med Chem Lett (2010) 1.02
Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii. ChemMedChem (2011) 1.01
Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. J Med Chem (2009) 1.01
Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives. Org Biomol Chem (2010) 0.99
Control of bacterial biofilms with marine alkaloid derivatives. Mol Biosyst (2008) 0.97
Inhibition and dispersion of proteobacterial biofilms. Chem Commun (Camb) (2008) 0.97
A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria. Eur J Med Chem (2012) 0.97
The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. Bioorg Med Chem (2009) 0.96
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii. Bioorg Med Chem Lett (2008) 0.95
Antibiofilm activity of a diverse oroidin library generated through reductive acylation. J Org Chem (2009) 0.95
Evaluation of dihydrooroidin as an antifouling additive in marine paint. Int Biodeterior Biodegradation (2009) 0.93
Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry (2012) 0.93
Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists. Bioorg Med Chem Lett (2010) 0.92
Total synthesis of kopsinine. Org Lett (2013) 0.91
Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance. ACS Chem Biol (2013) 0.91
Identification of antibiotics using small molecule variable ligand display on gold nanoparticles. Chem Commun (Camb) (2010) 0.91
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry (2005) 0.91
Structural studies on 4,5-disubstituted 2-aminoimidazole-based biofilm modulators that suppress bacterial resistance to β-lactams. ChemMedChem (2012) 0.91
Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. Org Biomol Chem (2009) 0.91
Growth inhibition of Staphylococcus aureus by mixed monolayer gold nanoparticles. Small (2011) 0.91
Overcoming resistance to β-lactam antibiotics. J Org Chem (2013) 0.90
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs. Bioorg Med Chem Lett (2006) 0.90
Programmable DNA-binding small molecules. Bioorg Med Chem (2013) 0.89
Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling. Org Biomol Chem (2011) 0.89
Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents. Chembiochem (2010) 0.89
Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. Pathog Dis (2014) 0.88
Intercepting bacterial indole signaling with flustramine derivatives. J Am Chem Soc (2011) 0.88
Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics. J Am Chem Soc (2014) 0.88
Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence. Future Med Chem (2013) 0.88
Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms. Org Biomol Chem (2011) 0.88
Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria. Bioorg Med Chem Lett (2010) 0.87
Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents. Bioorg Med Chem Lett (2010) 0.87
Biologically inspired strategies for combating bacterial biofilms. Curr Opin Pharmacol (2013) 0.86
Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens. J Med Chem (2014) 0.85
N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization. Org Biomol Chem (2013) 0.85
Anti-biofilm compounds derived from marine sponges. Mar Drugs (2011) 0.84
A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: antibiotic activity of a first generation library. Bioorg Med Chem Lett (2011) 0.84
Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction. J Org Chem (2008) 0.84
Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit. Chem Commun (Camb) (2011) 0.83
Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms. Medchemcomm (2013) 0.81
Tandem dispersion and killing of bacteria from a biofilm. Org Biomol Chem (2008) 0.81
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathog Dis (2014) 0.81
¹H, ¹³C, and ¹⁵N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. Biomol NMR Assign (2011) 0.81
Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. Drug Chem Toxicol (2012) 0.81
Highly active modulators of indole signaling alter pathogenic behaviors in Gram-negative and Gram-positive bacteria. Chemistry (2013) 0.80
A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity. Org Biomol Chem (2010) 0.80
Generation of 3-pyridyl biaryl systems via palladium-catalyzed Suzuki cross-couplings of aryl halides with 3-pyridylboroxin. J Org Chem (2004) 0.80
Targeting RNA with cysteine-constrained peptides. Bioorg Med Chem Lett (2007) 0.78
Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Curr Drug Deliv (2015) 0.77
Deconvoluting interspecies bacterial communication. Angew Chem Int Ed Engl (2012) 0.77
2-Aminopyrimidine as a novel scaffold for biofilm modulation. Org Biomol Chem (2012) 0.77
The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors. Medchemcomm (2012) 0.76
Innovative strategies for combating biofilm-based infections. Adv Exp Med Biol (2015) 0.76
Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii. Biomol NMR Assign (2012) 0.75
Medicinal chemistry: Forcing an enemy into the open. Nat Chem (2012) 0.75
Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis. Chem Commun (Camb) (2014) 0.75
Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers. Cancer Biol Ther (2013) 0.75
Screening an established natural product library identifies secondary metabolites that potentiate conventional antibiotics. ACS Infect Dis (2020) 0.75