Published in Endocrinology on October 30, 2008
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes (2010) 1.36
Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus. J Virol (2010) 1.27
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Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun (2010) 1.13
Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Front Immunol (2014) 1.04
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol (2013) 0.93
Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol (2013) 0.91
Genome-wide association analyses reveal significant loci and strong candidate genes for growth and fatness traits in two pig populations. Genet Sel Evol (2015) 0.90
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes (2015) 0.87
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Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. J Clin Biochem Nutr (2011) 0.87
Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition. PLoS One (2012) 0.84
Overexpression of thioredoxin-binding protein 2 increases oxidation sensitivity and apoptosis in human lens epithelial cells. Free Radic Biol Med (2013) 0.84
TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS Pathog (2013) 0.83
Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice. Atherosclerosis (2015) 0.82
Fibroblast growth factor 21 and its novel association with oxidative stress. Redox Biol (2016) 0.78
The use of transcriptomics to unveil the role of nutrients in Mammalian liver. ISRN Nutr (2013) 0.78
Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells. PLoS One (2014) 0.76
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
Redox control of cell death. Antioxid Redox Signal (2002) 2.08
Thiamine-regulated gene expression of Aspergillus oryzae thiA requires splicing of the intron containing a riboswitch-like domain in the 5'-UTR. FEBS Lett (2003) 1.87
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J (2002) 1.82
Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A (2004) 1.76
Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury. Am J Respir Crit Care Med (2003) 1.74
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem (2003) 1.57
Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome. Free Radic Biol Med (2007) 1.56
Thioredoxin-1 ameliorates myosin-induced autoimmune myocarditis by suppressing chemokine expressions and leukocyte chemotaxis in mice. Circulation (2004) 1.55
Thioredoxin in human and experimental sepsis. Crit Care Med (2009) 1.51
Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem (2003) 1.49
Thioredoxin as a molecular target of cyclopentenone prostaglandins. J Biol Chem (2003) 1.45
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol (2009) 1.40
A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P. J Biol Chem (2002) 1.39
Association of microRNA-34a overexpression with proliferation is cell type-dependent. Cancer Sci (2007) 1.31
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J (2005) 1.29
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal (2002) 1.29
High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer. Clin Cancer Res (2005) 1.28
The involvement of thioredoxin and thioredoxin binding protein-2 on cellular proliferation and aging process. Ann N Y Acad Sci (2005) 1.28
Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity. Circulation (2002) 1.26
Loss of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 in human T-cell leukemia virus type I-dependent T-cell transformation: implications for adult T-cell leukemia leukemogenesis. Cancer Res (2004) 1.25
Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1. J Biol Chem (2004) 1.24
17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J Biol Chem (2006) 1.20
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene (2002) 1.18
Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. Endocrinology (2005) 1.17
Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol (2003) 1.17
Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Oncogene (2003) 1.16
Thioredoxin prevents the development and progression of elastase-induced emphysema. Biochem Biophys Res Commun (2007) 1.16
Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2. Pharmacol Ther (2010) 1.15
Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. Invest Ophthalmol Vis Sci (2005) 1.15
Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun (2010) 1.13
An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. Biochemistry (2003) 1.13
Change of redox status and modulation by thiol replenishment in retinal photooxidative damage. Invest Ophthalmol Vis Sci (2002) 1.12
Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production. Gastroenterology (2006) 1.11
Shikimate and phenylalanine biosynthesis in the green lineage. Front Plant Sci (2013) 1.11
Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis. Mol Immunol (2002) 1.10
Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Lab Invest (2005) 1.10
Thioredoxin superfamily and thioredoxin-inducing agents. Ann N Y Acad Sci (2002) 1.09
Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice. Antioxid Redox Signal (2004) 1.08
Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart. Antioxid Redox Signal (2009) 1.08
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice. Hepatology (2003) 1.08
Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer. Semin Cancer Biol (2006) 1.06
Redox regulation of human thioredoxin network. Antioxid Redox Signal (2006) 1.06
Aberrant expression of selenoproteins in the progression of colorectal cancer. Cancer Lett (2007) 1.05
The evolution of phenylpropanoid metabolism in the green lineage. Crit Rev Biochem Mol Biol (2013) 1.04
Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. J Pharmacol Exp Ther (2008) 1.04
Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus. Antioxid Redox Signal (2008) 1.04
The role of thioredoxin in the aging process: involvement of oxidative stress. Antioxid Redox Signal (2003) 1.03
Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. J Neurosci (2005) 1.03
Attenuation of retinal photooxidative damage in thioredoxin transgenic mice. Neurosci Lett (2002) 1.02
Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection. Mol Neurobiol (2004) 1.02
Redox-active protein thioredoxin-1 administration ameliorates influenza A virus (H1N1)-induced acute lung injury in mice. Crit Care Med (2013) 1.02
Cytoprotective effect of thioredoxin against retinal photic injury in mice. Invest Ophthalmol Vis Sci (2002) 1.01
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci (2011) 0.99
Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur J Immunol (2008) 0.99
Redox imbalance and its control in HIV infection. Antioxid Redox Signal (2002) 0.98
Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice. J Hepatol (2005) 0.98
Redox regulation of cell growth and cell death. Biol Chem (2003) 0.98
Redox regulation of lung inflammation by thioredoxin. Antioxid Redox Signal (2005) 0.98
The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Free Radic Res (2006) 0.97
Redox-sensing release of human thioredoxin from T lymphocytes with negative feedback loops. J Immunol (2004) 0.97
The arbuscular mycorrhizal symbiosis influences sulfur starvation responses of Medicago truncatula. New Phytol (2012) 0.97
Thioredoxin 1 delivery as new therapeutics. Adv Drug Deliv Rev (2009) 0.97
Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells. J Biol Chem (2006) 0.96
Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. J Biol Chem (2009) 0.96
Borrelia turcica sp. nov., isolated from the hard tick Hyalomma aegyptium in Turkey. Int J Syst Evol Microbiol (2004) 0.96