Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 2745149)

Published in Cancer Biol Ther on January 01, 2009

Authors

James C Lee1, Ryan Krochak, Aaron Blouin, Stathis Kanterakis, Shampa Chatterjee, Evguenia Arguiri, Anil Vachani, Charalambos C Solomides, Keith A Cengel, Melpo Christofidou-Solomidou

Author Affiliations

1: Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA.

Articles citing this

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res (2010) 1.22

Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs (2009) 0.99

Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer (2013) 0.99

Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res (2012) 0.96

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer (2011) 0.94

Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J (2011) 0.88

Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs. Korean J Physiol Pharmacol (2013) 0.85

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation. J Proteome Res (2014) 0.84

Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study. Breast Cancer Res Treat (2009) 0.84

Space radiation-associated lung injury in a murine model. Am J Physiol Lung Cell Mol Physiol (2014) 0.84

Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci (2016) 0.83

Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration. J Pulm Respir Med (2015) 0.82

Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett (2013) 0.81

Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration. J Pulm Respir Med (2013) 0.81

Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage. Radiat Res (2014) 0.80

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study. BMC Complement Altern Med (2015) 0.80

Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes. BMC Complement Altern Med (2012) 0.80

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage. Int J Mol Sci (2015) 0.80

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis (2015) 0.79

Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulm Med (2012) 0.79

Chronic oxidative stress after irradiation: An unproven hypothesis. Med Hypotheses (2012) 0.78

Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed. Cancer Biol Ther (2014) 0.78

Potential protective properties of flax lignan secoisolariciresinol diglucoside. Nutr J (2015) 0.76

Recruitment of Gr1(+)CD11b (+)F4/80 (+) population in the bone marrow and spleen by irradiation-induced pulmonary damage. Inflammation (2015) 0.76

Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection. Biochim Biophys Acta (2016) 0.75

Articles cited by this

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys (1961) 19.31

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med (1991) 16.01

Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol (1994) 4.04

A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Arterioscler Thromb Vasc Biol (1997) 2.15

Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys (2000) 1.79

Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys (2000) 1.72

Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene (2000) 1.49

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys (2007) 1.46

Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N Engl J Med (1993) 1.45

KATP channels are an important component of the shear-sensing mechanism in the pulmonary microvasculature. Microcirculation (2006) 1.30

A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res (1989) 1.29

Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem (1999) 1.28

A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat Res (1989) 1.28

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Ther (1998) 1.26

Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol Cell Biochem (1997) 1.21

Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis. Int J Radiat Oncol Biol Phys (1994) 1.19

Outcome and prognostic factors for patients with non-small-cell lung cancer and severe radiation pneumonitis. Int J Radiat Oncol Biol Phys (2002) 1.15

Antioxidant Activity of Secoisolariciresinol Diglucoside-derived Metabolites, Secoisolariciresinol, Enterodiol, and Enterolactone. Int J Angiol (2000) 1.14

Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin Cancer Res (2007) 1.14

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology (2001) 1.13

Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo. Oncogene (1996) 1.12

Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol (2006) 1.11

Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr (2006) 1.10

Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real-time PCR. Mutat Res (2007) 1.10

Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints. Int J Radiat Biol (2000) 1.08

Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis (1996) 1.08

Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain. Radiat Res (1996) 1.07

Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.04

Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells. Cardiovasc Res (2006) 1.00

Chemopreventive effects of dietary flaxseed oil on colon tumor development. Nutr Cancer (2005) 0.98

Monocrotaline-induced pulmonary fibrosis in rats: amelioration by captopril and penicillamine. Proc Soc Exp Biol Med (1985) 0.98

Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Semin Oncol (2005) 0.95

Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. Exp Lung Res (2002) 0.93

Chemopreventive effects of dietary flaxseed on colon tumor development. Nutr Cancer (2006) 0.90

Stage IA-IIB Hodgkin's disease: management and outcome of extensive thoracic involvement. Int J Radiat Oncol Biol Phys (1997) 0.90

No effect on adenoma formation in Min mice after moderate amount of flaxseed. Eur J Nutr (2004) 0.81

Articles by these authors

Photodynamic therapy of cancer: an update. CA Cancer J Clin (2011) 6.08

Effect of HIV on survival in patients with non-small-cell lung cancer in the era of highly active antiretroviral therapy: a population-based study. Lancet Oncol (2012) 2.14

Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species. Am J Physiol Cell Physiol (2005) 1.95

Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease. Cancer Res (2009) 1.86

Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review. Clin Cancer Res (2005) 1.86

HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A (2010) 1.86

Combining multi-species genomic data for microRNA identification using a Naive Bayes classifier. Bioinformatics (2006) 1.82

PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress. Am J Physiol Lung Cell Mol Physiol (2003) 1.74

A blood-based proteomic classifier for the molecular characterization of pulmonary nodules. Sci Transl Med (2013) 1.69

Folate receptor alpha expression in lung cancer: diagnostic and prognostic significance. Oncotarget (2012) 1.67

MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circ Res (2013) 1.67

A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses. Clin Cancer Res (2007) 1.47

Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury. Nat Biotechnol (2003) 1.46

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest (2010) 1.46

Comparative analysis of colorimetric staining in skin using open-source software. Exp Dermatol (2015) 1.44

Cycloxygenase-2 inhibition augments the efficacy of a cancer vaccine. Clin Cancer Res (2006) 1.40

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest (2014) 1.33

PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood (2003) 1.33

Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Biochim Biophys Acta (2008) 1.33

Urinary volatile compounds as biomarkers for lung cancer: a proof of principle study using odor signatures in mouse models of lung cancer. PLoS One (2010) 1.31

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells. Blood (2002) 1.30

ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface. Blood (2003) 1.28

Intrapulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung. Cancer Res (2005) 1.26

Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res (2008) 1.26

Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. Clin Gastroenterol Hepatol (2007) 1.26

Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion. Mol Cancer Ther (2005) 1.24

Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system. Clin Cancer Res (2011) 1.24

A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. N Engl J Med (2015) 1.22

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res (2010) 1.22

Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem (2011) 1.21

Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy. Clin Cancer Res (2005) 1.19

Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent. Am J Physiol Lung Cell Mol Physiol (2005) 1.18

Advances in diagnostic bronchoscopy. Am J Respir Crit Care Med (2010) 1.18

Frequency of EGFR and KRAS mutations in patients with non small cell lung cancer by racial background: do disparities exist? Lung Cancer (2013) 1.16

Management of Pulmonary Nodules by Community Pulmonologists: A Multicenter Observational Study. Chest (2015) 1.16

A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions. Mol Ther (2010) 1.15

Local and systemic recurrence is the Achilles heel of cancer surgery. Ann Surg Oncol (2011) 1.15

Acute biological effects of simulating the whole-body radiation dose distribution from a solar particle event using a porcine model. Radiat Res (2011) 1.14

Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature. Blood (2007) 1.14

Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biol Ther (2009) 1.14

MicroRNA expression profiles of whole blood in lung adenocarcinoma. PLoS One (2012) 1.13

Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras. Cancer Res (2005) 1.13

Measuring brain lesion progression with a supervised tissue classification system. Med Image Comput Comput Assist Interv (2008) 1.12

Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharmacol Exp Ther (2009) 1.11

Rac and PI3 kinase mediate endothelial cell-reactive oxygen species generation during normoxic lung ischemia. Antioxid Redox Signal (2008) 1.11

Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol (2006) 1.11

Small airway pathology and bronchoreversibility in advanced emphysema. COPD (2010) 1.11

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. J Neurovirol (2014) 1.11

Components necessary for high-quality lung cancer screening: American College of Chest Physicians and American Thoracic Society Policy Statement. Chest (2015) 1.11

Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr (2006) 1.10

Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am J Respir Crit Care Med (2010) 1.10

Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. J Investig Med (2002) 1.08

Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut (2007) 1.08

Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am J Physiol Lung Cell Mol Physiol (2006) 1.08

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res (2013) 1.07

A trial of intrapleural adenoviral-mediated Interferon-α2b gene transfer for malignant pleural mesothelioma. Am J Respir Crit Care Med (2011) 1.07

B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models. J Immunother (2008) 1.07

Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem (2013) 1.07

The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes. Cancer Res (2007) 1.06

Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.04

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Mol Pharmacol (2012) 1.04

DTI based diagnostic prediction of a disease via pattern classification. Med Image Comput Comput Assist Interv (2010) 1.04

Small airway mucous metaplasia and inflammation in chronic obstructive pulmonary disease. COPD (2008) 1.03

Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction. Am J Physiol Heart Circ Physiol (2004) 1.03

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med (2009) 1.03

Kinetics of soluble mesothelin in patients with malignant pleural mesothelioma during treatment. Am J Respir Crit Care Med (2009) 1.02

PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone (2013) 1.01

Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature. J Pharmacol Exp Ther (2002) 1.00

Photodynamic therapy for the treatment of non-small cell lung cancer. J Thorac Dis (2012) 0.99

Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer (2013) 0.99

Small airway morphometry and improvement in pulmonary function after lung volume reduction surgery. Am J Respir Crit Care Med (2004) 0.98

Ca2+ flux through voltage-gated channels with flow cessation in pulmonary microvascular endothelial cells. Microcirculation (2004) 0.98

Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its 15 metabolites by LC-MS. Bioanalysis (2011) 0.97

Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer. PLoS One (2012) 0.96

Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res (2012) 0.96