Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMC 2719983)

Published in Histopathology on November 01, 2008

Authors

K Nosho1, T Kawasaki, A T Chan, M Ohnishi, Y Suemoto, G J Kirkner, C S Fuchs, S Ogino

Author Affiliations

1: Department of Medical Oncology, Dana-Farber Cancer Institute, & Harvard Medical School, Boston, MA, USA.

Articles citing this

A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology (2009) 2.56

Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 2.00

Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. Gastroenterology (2008) 1.99

Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol (2013) 1.95

Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. Neoplasia (2009) 1.39

NRAS mutations are rare in colorectal cancer. Diagn Mol Pathol (2010) 1.38

Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer. Diagn Pathol (2013) 1.28

BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome. Br J Cancer (2010) 1.23

Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int J Cancer (2011) 1.20

CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. Int J Cancer (2010) 1.11

JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. Neoplasia (2009) 1.10

Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study. Biol Sex Differ (2011) 1.04

A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. Am J Gastroenterol (2009) 1.03

A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin Cancer Res (2009) 1.02

A cohort study of p27 localization in colon cancer, body mass index, and patient survival. Cancer Epidemiol Biomarkers Prev (2009) 1.02

Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer. BMC Cancer (2013) 0.84

ATG4B promotes colorectal cancer growth independent of autophagic flux. Autophagy (2014) 0.82

TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells. Sci Rep (2016) 0.81

Expression of Cyclin D1 Is Associated with β-Catenin Expression and Correlates with Good Prognosis in Colorectal Adenocarcinoma. Transl Oncol (2012) 0.78

The role of oncogenes in gastrointestinal cancer. Gastrointest Cancer Res (2010) 0.78

Articles cited by this

The epigenomics of cancer. Cell (2007) 30.91

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res (1998) 20.08

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63

CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75

MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30

Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med (2007) 9.04

The Nurses' Health Study: lifestyle and health among women. Nat Rev Cancer (2005) 8.19

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology (2007) 7.16

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology (2005) 6.34

Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn (2005) 6.00

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44

Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn (2006) 3.98

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut (2006) 3.59

Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn (2007) 3.56

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer (2007) 3.28

Molecular classification and correlates in colorectal cancer. J Mol Diagn (2007) 3.25

Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. Mod Pathol (2006) 2.80

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology (1996) 2.16

Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer. Clin Cancer Res (2005) 2.13

Colorectal serrated adenocarcinoma. Histopathology (2007) 2.04

Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. Neoplasia (2007) 1.85

Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Neoplasia (2006) 1.84

Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology (2006) 1.78

Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. Mod Pathol (2006) 1.57

Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis. Histopathology (2007) 1.53

Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin Cancer Res (2007) 1.33

Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters. Am J Pathol (2000) 1.33

Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. J Pathol (2006) 1.28

TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. Hum Pathol (2007) 1.27

Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer. Cancer Res (2000) 1.20

c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications. Histopathology (2007) 1.20

CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer. Cancer Res (2001) 1.14

Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. Hum Pathol (2000) 1.09

Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative. Int J Cancer (2000) 1.08

Expression of cyclin D1 and retinoblastoma protein in colorectal cancer. Eur J Cancer (1998) 1.03

Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. J Natl Cancer Inst (2001) 1.01

p53: at the crossroad between cancer and ageing. J Pathol (2007) 0.98

IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. Neoplasia (2007) 0.98

Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC ) gene. Histopathology (2007) 0.97

Polymorphism of the cyclin D1 gene, CCND1, and risk for incident sporadic colorectal adenomas. Cancer Res (2003) 0.95

Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability. Clin Cancer Res (2008) 0.94

Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer. J Pathol (2006) 0.90

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int J Cancer (2006) 0.88

Absence of association between cyclin D1 (CCND1) G870A polymorphism and age of onset in hereditary nonpolyposis colorectal cancer. Cancer Lett (2006) 0.86

Molecular alterations associated with cyclin D1 overexpression in endometrial cancer. Int J Cancer (2004) 0.85

Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology (2006) 0.79

Articles by these authors

Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22

A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics (1974) 9.97

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19

[Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi (1967) 9.06

Cost-effectiveness of screening for colorectal cancer in the general population. JAMA (2000) 5.88

Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA (2001) 4.30

EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis (2005) 4.17

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut (2006) 3.59

Adjuvant intra-arterial iodine-131-labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial. Lancet (1999) 3.54

Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation (1997) 3.27

Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res (1999) 2.87

Serum lectin with known structure activates complement through the classical pathway. J Biol Chem (1987) 2.79

The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage. Mol Microbiol (2000) 2.77

Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst (2000) 2.46

Essential role of the small GTPase Rac in disease resistance of rice. Proc Natl Acad Sci U S A (2001) 2.45

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun (1995) 2.42

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer (2009) 2.39

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol (1997) 2.29

Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum. J Biol Chem (1991) 2.23

Isolation and characterization of an avian hepatic binding protein specific for N-acetylglucosamine-terminated glycoproteins. J Biol Chem (1977) 2.18

Sequelae of Kawasaki disease in adolescents and young adults. J Am Coll Cardiol (1996) 2.18

Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation (1989) 2.14

Impact of patient and provider characteristics on the treatment and outcomes of colorectal cancer. J Natl Cancer Inst (2001) 2.10

Temperature dependence of amide proton chemical shifts: the secondary structures of gramicidin S and valinomycin. Biochem Biophys Res Commun (1969) 2.08

How successful is high-dose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma? Int J Radiat Oncol Biol Phys (1998) 2.08

The molecular basis for the absence of N-glycolylneuraminic acid in humans. J Biol Chem (1998) 2.07

The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med (1978) 2.05

Isolation and characterization of a mannan-binding protein from rabbit liver. Biochem Biophys Res Commun (1978) 2.04

Airway management of a child with temporomandibular joint ankylosis following otitis media. Anaesthesia (2002) 2.01

Adult coronary artery disease probably due to childhood Kawasaki disease. Lancet (1992) 1.97

Nocturnal blood pressure fall on ambulatory monitoring in a large international database. The "Ad Hoc' Working Group. Hypertension (1997) 1.90

Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography. Gut (2004) 1.89

Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol (2001) 1.87

Incidence survey of Kawasaki disease in 1997 and 1998 in Japan. Pediatrics (2001) 1.85

Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing. Proc Natl Acad Sci U S A (1987) 1.84

The complete nucleotide sequence of phi CTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: implications for phage evolution and horizontal gene transfer via bacteriophages. Mol Microbiol (1999) 1.83

Isolation and characterization of a mannan-binding protein from human serum. J Biochem (1983) 1.83

Kawasaki disease in families. Pediatrics (1989) 1.83

Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Cancer Res (1999) 1.82

Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog. Proc Natl Acad Sci U S A (1970) 1.82

Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res (1999) 1.77

Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol (1998) 1.75

Chemical and physical properties of an hepatic membrane protein that specifically binds asialoglycoproteins. J Biol Chem (1976) 1.73

Thoracoscopic talc insufflation versus talc slurry for symptomatic malignant pleural effusion. Ann Thorac Surg (1996) 1.72

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol (2000) 1.72

Alteration of the structural properties of starch components by the lack of an isoform of starch branching enzyme in rice seeds. J Biol Chem (1993) 1.71

Body mass index and Barrett's oesophagus in women. Gut (2009) 1.70

Solution conformation of valinomycin-potassium ion complex. Science (1970) 1.69

Genetic mapping with a thiamine-requiring auxotroph of Escherichia coli K-12 defective in thiamine phosphate pyrophosphorylase. J Bacteriol (1968) 1.66

High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure. J Am Coll Cardiol (2000) 1.64

BHV-1 adsorption is mediated by the interaction of glycoprotein gIII with heparinlike moiety on the cell surface. Virology (1991) 1.63

High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol (2005) 1.61

Test reactions for a stopped-flow apparatus. Reduction of 2,6-dichlorophenolindophenol and potassium ferricyanide by L-ascorbic acid. Anal Biochem (1978) 1.59

Enhancement of local control in locally advanced node-positive nasopharyngeal carcinoma by adjunctive chemotherapy. Int J Radiat Oncol Biol Phys (1999) 1.59

A nationwide incidence survey of Kawasaki disease in 1985-1986 in Japan. J Infect Dis (1988) 1.57

Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C. Infect Immun (2001) 1.57

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. Oncogene (2009) 1.53

Evaluation of posttreatment response of hepatocellular carcinoma with contrast-enhanced coded phase-inversion harmonic US: comparison with dynamic CT. Radiology (2001) 1.52

Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. J Pathol (2008) 1.52

Dialysis patients' preferences regarding cardiopulmonary resuscitation and withdrawal of dialysis in Japan. Am J Kidney Dis (2001) 1.51

Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med (1998) 1.51

A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity. J Biochem (1989) 1.50

Complete nucleotide sequence of the prophage VT1-Sakai carrying the Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli O157:H7 strain derived from the Sakai outbreak. Gene (2000) 1.50

The nucleotide sequence of cDNA for a Drosophila ribosomal protein with homology to rat ribosomal protein S26. Nucleic Acids Res (1989) 1.48

A craniocervical injury-induced syringomyelia caused by central canal dilation secondary to acquired tonsillar herniation. Case report. J Neurosurg (2001) 1.48

Phage conversion of exfoliative toxin A production in Staphylococcus aureus. Mol Microbiol (2000) 1.47

Role of interleukin-10 on hyporesponsiveness of endotoxin during surgery. Crit Care Med (2000) 1.47

Conformations of cyclic peptides. IV. Nuclear magnetic resonance studies of cyclo-pentaglycyl-L-leucyl and cyclo-diglycyl-L-histidyldiglycyl-L-tyrosyl. Biochemistry (1969) 1.46

Difference in direct charge-parity violation between charged and neutral B meson decays. Nature (2008) 1.46

Dietary fat and protein in relation to risk of non-Hodgkin's lymphoma among women. J Natl Cancer Inst (1999) 1.45

Regulation of the TAK1 signaling pathway by protein phosphatase 2C. J Biol Chem (2000) 1.44

Identification, cDNA cloning, and gene expression of soluble starch synthase in rice (Oryza sativa L.) immature seeds. Plant Physiol (1993) 1.43

Dislocated intraocular lens fixation using intraocular cowhitch knot. Am J Ophthalmol (2001) 1.43

An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries. Immunogenetics (2000) 1.42

Variable Bcl-2 phenotype in benign and malignant lesions of urothelium. Cancer Lett (1998) 1.42

Lesion mimic mutants of rice with alterations in early signaling events of defense. Plant J (1999) 1.42

Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA. Cancer Res (2000) 1.42

[The desensitization therapy in children with nasal allergy to house dust]. Nihon Jibiinkoka Gakkai Kaiho (1989) 1.42

Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer (2009) 1.41

Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction. Eur Heart J (2003) 1.41

Clinical usefulness of serum 1,5-anhydroglucitol in monitoring glycaemic control. Lancet (1996) 1.41

Colonic ulceration caused by administration of loxoprofen sodium. Intern Med (1999) 1.40

Paradoxical positive nitrogen balance in burn patients receiving high-dose administration of insulin for nutritional care. Surgery (1997) 1.40

Response to interferon-alpha 2a in patients with e antigen-negative chronic hepatitis B. J Clin Gastroenterol (1997) 1.40

A case of tachycardia-induced cardiomyopathy due to chronic ectopic atrial tachycardia. Clin Cardiol (1993) 1.39

Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid. J Biol Chem (1995) 1.39

Thiamine uptake in Escherichia coli. I. General properties of thiamine uptake system in Escherichia coli. Arch Biochem Biophys (1969) 1.39

Anisotropy and corotation of galactic cosmic rays. Science (2006) 1.39

Effect of low concentration of epinephrine on human platelet aggregation analyzed by particle counting method and confocal microscopy. J Lab Clin Med (1997) 1.39

Thromboembolic events with paclitaxel. Clin Oncol (R Coll Radiol) (1996) 1.39

A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochem Biophys Res Commun (1996) 1.38

Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium. Biomaterials (2001) 1.38

The mechanism of carbohydrate-mediated complement activation by the serum mannan-binding protein. J Biol Chem (1990) 1.36

Relations among climbing fiber responses of nearby Purkinje Cells. J Neurophysiol (1972) 1.34

A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer. Ann Oncol (2012) 1.34