Published in Biochem J on September 15, 1991
All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells. J Physiol (1992) 1.49
A model of calcium dynamics in cardiac myocytes based on the kinetics of ryanodine-sensitive calcium channels. Biophys J (1994) 1.48
IP(3) receptors: toward understanding their activation. Cold Spring Harb Perspect Biol (2010) 1.42
Simplification and analysis of models of calcium dynamics based on IP3-sensitive calcium channel kinetics. Biophys J (1996) 1.29
The opening of the inositol 1,4,5-trisphosphate-sensitive Ca2+ channel in rat cerebellum is inhibited by caffeine. Biochem J (1992) 1.23
Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells. Br J Pharmacol (1993) 1.19
The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes. Biochem J (1993) 1.07
Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells. Br J Pharmacol (1995) 1.04
Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca2+ mobilization in permeabilized hepatocytes. Biochem J (1993) 1.04
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation. Biochem J (2001) 1.02
Regulation of inositol trisphosphate receptors by luminal Ca2+ contributes to quantal Ca2+ mobilization. EMBO J (1996) 0.99
A steady-state mechanism can account for the properties of inositol 2,4,5-trisphosphate-stimulated Ca2+ release from permeabilized L1210 cells. Biochem J (1993) 0.98
Calcium release in HSY cells conforms to a steady-state mechanism involving regulation of the inositol 1,4,5-trisphosphate receptor Ca2+ channel by luminal [Ca2+]. J Cell Biol (1996) 0.98
Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores. Biochem J (1994) 0.94
Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to be mediated by their desensitization or regulation by luminal or cytosolic Ca2+. Biochem J (1997) 0.93
Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores. Biochem J (2003) 0.90
Quantal responses to inositol 1,4,5-trisphosphate are not a consequence of Ca2+ regulation of inositol 1,4,5-trisphosphate receptors. Biochem J (1995) 0.87
Oxidized glutathione decreases luminal Ca2+ content of the endothelial cell ins(1,4,5)P3-sensitive Ca2+ store. Biochem J (1995) 0.86
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor. Biochem J (1993) 0.86
Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes. Biochem J (1994) 0.84
Effect of adenine nucleotides on myo-inositol-1,4,5-trisphosphate-induced calcium release. Biochem J (1997) 0.83
Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells. Biochem J (1996) 0.81
Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes. Biochem J (1998) 0.80
Highly cooperative Ca2+ elevations in response to Ins(1,4,5)P3 microperfusion through a patch-clamp pipette. Biophys J (1995) 0.79
Quantal calcium release and calcium entry in the pancreatic acinar cell. Yale J Biol Med (1993) 0.78
A novel Ca2+-induced Ca2+ release mechanism mediated by neither inositol trisphosphate nor ryanodine receptors. Biochem J (2002) 0.78
Slow kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release: is the release 'quantal' or 'non-quantal'? Biochem J (1997) 0.77
Inhibition of the cerebellar inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by ethanol and other aliphatic alcohols. Biochem J (1996) 0.77
Inositol phosphates and cell signalling. Nature (1989) 17.78
'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism. FEBS Lett (1990) 5.35
Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells. Nature (1988) 3.57
Hormone-evoked calcium release from intracellular stores is a quantal process. J Biol Chem (1989) 2.56
A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils. Nature (1986) 2.42
Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate. Biochemistry (1990) 2.30
Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate. Proc Natl Acad Sci U S A (1990) 2.18
Localized all-or-none calcium liberation by inositol trisphosphate. Science (1990) 1.87
Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes. J Biol Chem (1990) 1.63
The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration. Biochem J (1990) 1.54
Calcium mediates the interconversion between two states of the liver inositol 1,4,5-trisphosphate receptor. J Biol Chem (1990) 1.49
Fast kinetics of calcium release induced by myo-inositol trisphosphate in permeabilized rat hepatocytes. J Biol Chem (1989) 1.48
Temperature and nucleotide dependence of calcium release by myo-inositol 1,4,5-trisphosphate in cultured vascular smooth muscle cells. J Biol Chem (1985) 1.30
Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors. Biochem J (1990) 1.26
Heparin inhibits the inositol 1,4,5-trisphosphate-induced Ca2+ release from rat liver microsomes. FEBS Lett (1988) 1.23
Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium. Biochem J (1989) 1.17
Quantal release of Ca2+ from intracellular stores by InsP3: tests of the concept of control of Ca2+ release by intraluminal Ca2+. Proc Biol Sci (1991) 1.09
Changes in the epithelium of the cervix uteri. A study by the panel of pathologists engaged in the survey of carcinoma in situ carried out by the Royal College of Obstetricians and Gynaecologists. J Obstet Gynaecol Br Commonw (1966) 5.13
The histology and cytology of changes in the epithelium of the cervix uteri. J Clin Pathol (1969) 4.25
Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol (1989) 2.89
New duplication-generating inversions in Neurospora. Can J Genet Cytol (1969) 2.30
Nucleotide sequence of 4.5 S ribonucleic acid of Novikoff hepatoma cell nuclei. J Biol Chem (1972) 2.30
A pericentric inversion in Neurospora, with unstable duplication progeny. Genetics (1967) 2.25
Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging. Neoplasia (1999) 2.24
Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores. Nature (1991) 2.16
Use of lipid composition and metabolism to examine structure and activity of estuarine detrital microflora. Appl Environ Microbiol (1977) 2.12
New markers and map sequences in Neurospora crassa, with a description of mapping by duplication coverage, and of multiple translocation stocks for testing linkage. Genetica (1969) 1.97
A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin. J Physiol (1999) 1.94
Isolation and characterization of protein A24, a "histone-like" non-histone chromosomal protein. J Biol Chem (1975) 1.91
T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum (2002) 1.88
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res (2000) 1.81
Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer (1999) 1.79
Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas. Biochem J (1986) 1.74
Randomized trial of adjuvant human interferon gamma versus observation in high-risk cutaneous melanoma: a Southwest Oncology Group study. J Natl Cancer Inst (1995) 1.67
Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity. Curr Biol (1997) 1.63
Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization. J Biol Chem (1993) 1.59
Luminal Ca2+ increases the sensitivity of Ca2+ stores to inositol 1,4,5-trisphosphate. Mol Pharmacol (1992) 1.56
Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+. Biochem J (1997) 1.49
All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells. J Physiol (1992) 1.49
The management of dysplasia, carcinoma in situ and microcarcinoma of the cervix. J Obstet Gynaecol Br Commonw (1973) 1.48
Two calcium-binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformational states. Biochem J (1994) 1.47
Randomized clinical trial of fluid and salt restriction compared with a controlled liberal regimen in elective gastrointestinal surgery. Br J Surg (2013) 1.46
Vasopressin stimulation of Ca2+ mobilization, two bivalent cation entry pathways and Ca2+ efflux in A7r5 rat smooth muscle cells. J Physiol (1995) 1.45
The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor. J Biol Chem (1992) 1.44
Calcium and inositol trisphosphate receptors. J Membr Biol (1995) 1.41
Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca(2+). Curr Biol (1999) 1.39
Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochem Pharmacol (1999) 1.38
Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate-sensitive stores in rat hepatocytes. J Physiol (1992) 1.35
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells. Cancer Res (1996) 1.33
Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors. Biochem J (1990) 1.26
Spontaneous Ca2+ spiking in a vascular smooth muscle cell line is independent of the release of intracellular Ca2+ stores. J Biol Chem (1993) 1.24
Two-dimensional electrophoresis of proteins of citric acid nuclei prepared with aid of a Tissumizer. Exp Cell Res (1973) 1.23
Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro. J Natl Cancer Inst (1992) 1.23
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. Clin Cancer Res (2001) 1.22
Biphasic effects of cytosolic Ca2+ on Ins(1,4,5)P3-stimulated Ca2+ mobilization in hepatocytes. J Biol Chem (1993) 1.22
Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors. Mol Pharmacol (1994) 1.21
Structural analysis of the glycine-rich, arginine-rich histone. 3. Sequence of the amino-terminal half of the molecule containing the modified lysine residues and the total sequence. J Biol Chem (1969) 1.21
Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: redistribution of calmodulin as a possible means of regulating Ca2+ mobilization. Proc Natl Acad Sci U S A (1997) 1.20
Human tumor models in the severe combined immune deficient (scid) mouse. Cancer Chemother Pharmacol (1997) 1.20
A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors. Biochem J (1998) 1.15
Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate. Biochemistry (1998) 1.14
The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor. J Immunol (1987) 1.13
Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes. Biochem J (1985) 1.12
Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors. Biochem J (2000) 1.12
Evaluation of cisplatin intensity in metastatic non-small-cell lung cancer: a phase III study of the Southwest Oncology Group. J Clin Oncol (1993) 1.12
Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum. Biochem J (1990) 1.07
Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor. Biochem J (2001) 1.03
Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors. Biochemistry (1997) 1.03
Parathyroid hormone controls the size of the intracellular Ca(2+) stores available to receptors linked to inositol trisphosphate formation. J Biol Chem (2000) 1.01
Type 3 inositol trisphosphate receptors in RINm5F cells are biphasically regulated by cytosolic Ca2+ and mediate quantal Ca2+ mobilization. Biochem J (1999) 1.00
The fractionation of arginine-rich histones from fetal calf thymus by exclusion chromatography. J Biol Chem (1967) 1.00
Caffeine-stimulated Ca2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors. Biochem J (1993) 1.00
Delayed autoregulation of the Ca2+ signals resulting from capacitative Ca2+ entry in bovine pulmonary artery endothelial cells. J Physiol (1997) 1.00
Regulation of inositol trisphosphate receptors by luminal Ca2+ contributes to quantal Ca2+ mobilization. EMBO J (1996) 0.99
Differences in chromatin proteins of growing and non-growing tissues. Exp Cell Res (1975) 0.98
A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland. Biochem Biophys Res Commun (1986) 0.98
Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels. Mol Pharmacol (1996) 0.98
Extracellular heavy-metal ions stimulate Ca2+ mobilization in hepatocytes. Biochem J (1999) 0.97
2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores. FEBS Lett (1990) 0.96
Attributes of a good practicing physician. J Med Educ (1971) 0.95
Prolonged exposure to inositol 1,4,5-trisphosphate does not cause intrinsic desensitization of the intracellular Ca(2+)-mobilizing receptor. J Biol Chem (1992) 0.95
Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals. Biophys J (1996) 0.95
Regulation of inositol 1,4,5-trisphosphate receptors. J Exp Biol (1993) 0.94
A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver. Proc Natl Acad Sci U S A (1976) 0.94
Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to be mediated by their desensitization or regulation by luminal or cytosolic Ca2+. Biochem J (1997) 0.93
Structural determinants of adenophostin A activity at inositol trisphosphate receptors. Mol Pharmacol (2001) 0.93
Heparin and other polyanions uncouple alpha 1-adrenoceptors from G-proteins. Biochem J (1991) 0.91
Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA. Biochem J (1998) 0.91
Helix pomatia in breast cancer. Lancet (1991) 0.91
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A. Biochem J (2000) 0.90
Receptor-regulated Ca2+ entry: secret pathway or secret messenger? Trends Pharmacol Sci (1990) 0.90
Isomers of inositol trisphosphate in exocrine pancreas. Biochem J (1986) 0.90
Expression and distribution of InsP(3) receptor subtypes in proliferating vascular smooth muscle cells. Biochem Biophys Res Commun (2000) 0.90
Oxytocin increases the [Ca2+]i sensitivity of human myometrium during the falling phase of phasic contractions. Am J Physiol (1999) 0.90
High-dose chemotherapy with autologous peripheral blood progenitor cell support for primary breast cancer in patients with 4-9 involved axillary lymph nodes. Bone Marrow Transplant (1997) 0.89
Receptors linked to polyphosphoinositide hydrolysis stimulate Ca2+ extrusion by a phospholipase C-independent mechanism. Biochem J (1999) 0.89
Long-term engraftment of fresh human myeloma cells in SCID mice. Blood (1992) 0.89
Functional properties of Drosophila inositol trisphosphate receptors. Biochem J (2001) 0.89
Alteration of human tumor cell adhesion by high-strength static magnetic fields. Invest Radiol (1992) 0.89
Two-dimensional gel electrophoresis of acid-extractable nuclear proteins of regenerating and thioacetamide-treated rat liver, Morris 9618a hepatoma, and Walker 256 carcinosarcoma. Cancer Res (1974) 0.89
Inositol trisphosphate and calcium signaling. Cold Spring Harb Symp Quant Biol (1988) 0.88
Different receptors use inositol trisphosphate to mobilize Ca(2+) from different intracellular pools. Biochem J (2000) 0.88
Formation and biological action of inositol 1,4,5-trisphosphate. Fed Proc (1986) 0.88
Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A. J Med Chem (2000) 0.87
Quantal responses to inositol 1,4,5-trisphosphate are not a consequence of Ca2+ regulation of inositol 1,4,5-trisphosphate receptors. Biochem J (1995) 0.87
Regulation of Ca2+ mobilization by Ins (1,4,5)P3 and intraluminal Ca2+ in permeabilized hepatocytes. Biochem Soc Trans (1991) 0.87
Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors. Biochem J (1997) 0.87
A large scale procedure for isolation of the glycine-rich, arginine-rich histone and the arginine-rich, lysine-rich histone in a highly purified form. J Biol Chem (1968) 0.87
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor. Biochem J (1993) 0.86
Differentiation of BC3H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway. Biochem J (1996) 0.85
Amino acid sequence of the COOH-terminal portion of the arginine-lysine-rich histone of calf thymus. J Biol Chem (1972) 0.85
Why do hormones stimulate Ca2+ mobilization? Biochem Soc Trans (1995) 0.85
Single umbilical artery is associated with an increased incidence of structural and chromosomal anomalies and growth restriction. Am J Perinatol (2000) 0.85
Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate. Bioorg Med Chem Lett (1999) 0.84
Carboxyl-terminal sequence of the glycine-arginine-rich histone from bovine lymphosarcoma, Novikoff hepatoma and fetal calf thymus. Biochim Biophys Acta (1969) 0.84