PubRank

John M Leong

Author PubWeight™ 70.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell 2012 4.44
2 EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Dev Cell 2004 3.36
3 Hierarchical regulation of WASP/WAVE proteins. Mol Cell 2008 2.86
4 B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 2004 2.60
5 A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals. Mol Microbiol 2002 1.73
6 The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 2003 1.67
7 Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7. Curr Opin Microbiol 2003 1.56
8 Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infect Immun 2006 1.55
9 Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci U S A 2003 1.50
10 Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure 2012 1.47
11 Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A 2009 1.46
12 Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature 2008 1.43
13 Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Mol Microbiol 2005 1.41
14 Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol 2004 1.39
15 Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun 2008 1.36
16 Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling. Nat Rev Microbiol 2006 1.34
17 Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir. Mol Microbiol 2005 1.32
18 Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding. Mol Microbiol 2003 1.24
19 Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes. Infect Immun 2002 1.16
20 Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect Immun 2006 1.13
21 Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli. Cell Microbiol 2013 1.12
22 Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor. Mol Microbiol 2004 1.11
23 Enterohaemorrhagic and enteropathogenic Escherichia coli Tir proteins trigger a common Nck-independent actin assembly pathway. Cell Microbiol 2007 1.11
24 Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol 2007 1.09
25 MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 2007 1.09
26 Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length. Cell Microbiol 2006 1.08
27 Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. PLoS Pathog 2008 1.08
28 Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells. Infect Immun 2011 1.06
29 EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cell Microbiol 2007 1.06
30 Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Proc Natl Acad Sci U S A 2010 1.04
31 Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7. Mol Microbiol 2011 1.02
32 Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket. Mol Microbiol 2002 1.01
33 Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood 2003 1.01
34 A novel murine infection model for Shiga toxin-producing Escherichia coli. J Clin Invest 2012 1.01
35 Targeting type III secretion in Yersinia pestis. Antimicrob Agents Chemother 2008 1.00
36 In vitro CpG methylation increases the transformation efficiency of Borrelia burgdorferi strains harboring the endogenous linear plasmid lp56. J Bacteriol 2008 1.00
37 Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution. Front Cell Infect Microbiol 2013 0.98
38 Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. PLoS Pathog 2010 0.97
39 The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS One 2011 0.91
40 Allele- and tir-independent functions of intimin in diverse animal infection models. Front Microbiol 2012 0.91
41 Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host. Front Microbiol 2011 0.90
42 Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences. Infect Immun 2005 0.86
43 Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure 2011 0.85
44 Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion. Mol Microbiol 2011 0.83
45 The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cell Microbiol 2014 0.80
46 Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo. Infect Immun 2008 0.80
47 Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. J Immunol 2010 0.80
48 Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli. J Biol Chem 2012 0.79
49 The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res 2009 0.78
50 Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun 2012 0.78
51 Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infect Dis Clin North Am 2013 0.78
52 No better time to FRET: shedding light on host pathogen interactions. J Biol 2010 0.78
53 Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infect Immun 2009 0.77
54 Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes. Sci Signal 2011 0.76
55 Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS Pathog 2011 0.76
56 Interaction of enterohemorrhagic Escherichia coli (EHEC) with mammalian cells: cell adhesion, type III secretion, and actin pedestal formation. Curr Protoc Microbiol 2007 0.76
57 Rapid allelic exchange in enterohemorrhagic Escherichia coli (EHEC) and other E. coli using lambda red recombination. Curr Protoc Microbiol 2006 0.76
58 Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Front Microbiol 2011 0.75
59 New approaches and old problems in the shadow of bioterrorism. Trends Microbiol 2002 0.75