|
1
|
Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
|
Proc Natl Acad Sci U S A
|
2003
|
6.46
|
|
2
|
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.
|
J Lipid Res
|
2006
|
3.64
|
|
3
|
Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease.
|
Sci Transl Med
|
2010
|
3.42
|
|
4
|
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
|
Circ Res
|
2004
|
2.50
|
|
5
|
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.
|
Endocrinology
|
2010
|
2.35
|
|
6
|
Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.
|
Cell Metab
|
2011
|
2.16
|
|
7
|
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
|
J Lipid Res
|
2004
|
2.08
|
|
8
|
Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system.
|
J Biol Chem
|
2001
|
1.90
|
|
9
|
As a matter of fat.
|
Cell Metab
|
2009
|
1.85
|
|
10
|
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.
|
J Lipid Res
|
2011
|
1.76
|
|
11
|
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
|
J Biol Chem
|
2006
|
1.73
|
|
12
|
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
|
J Biol Chem
|
2003
|
1.69
|
|
13
|
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
|
Proc Natl Acad Sci U S A
|
2006
|
1.62
|
|
14
|
DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity.
|
J Biol Chem
|
2009
|
1.56
|
|
15
|
A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death.
|
Mol Biol Cell
|
2005
|
1.55
|
|
16
|
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.
|
J Clin Invest
|
2008
|
1.51
|
|
17
|
Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.
|
J Biol Chem
|
2008
|
1.45
|
|
18
|
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.
|
Proc Natl Acad Sci U S A
|
2003
|
1.35
|
|
19
|
The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.
|
J Biol Chem
|
2005
|
1.33
|
|
20
|
Mechanisms of lipoapoptosis: implications for human heart disease.
|
Trends Cardiovasc Med
|
2002
|
1.28
|
|
21
|
Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes.
|
J Lipid Res
|
2005
|
1.28
|
|
22
|
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
|
Nat Genet
|
2002
|
1.23
|
|
23
|
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.
|
Proc Natl Acad Sci U S A
|
2004
|
1.21
|
|
24
|
Lipotoxicity in the heart.
|
Curr Hypertens Rep
|
2005
|
1.19
|
|
25
|
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
|
J Biol Chem
|
2008
|
1.17
|
|
26
|
The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress.
|
J Biol Chem
|
2009
|
1.13
|
|
27
|
cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells.
|
J Biol Chem
|
2003
|
1.11
|
|
28
|
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.
|
J Biol Chem
|
2012
|
1.08
|
|
29
|
Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice.
|
Biochem Biophys Res Commun
|
2006
|
1.07
|
|
30
|
Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.
|
J Lipid Res
|
2013
|
1.07
|
|
31
|
Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy.
|
Circ Res
|
2008
|
1.07
|
|
32
|
TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway.
|
J Immunol
|
2012
|
1.00
|
|
33
|
Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.
|
Am J Respir Crit Care Med
|
2015
|
0.95
|
|
34
|
Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy.
|
J Cardiometab Syndr
|
2006
|
0.93
|
|
35
|
Oligomerization of the murine fatty acid transport protein 1.
|
J Biol Chem
|
2003
|
0.89
|
|
36
|
Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment.
|
Arterioscler Thromb Vasc Biol
|
2012
|
0.87
|
|
37
|
Macrophages modulate cardiac function in lipotoxic cardiomyopathy.
|
Am J Physiol Heart Circ Physiol
|
2012
|
0.86
|
|
38
|
Diabetic cardiovascular disease: getting to the heart of the matter.
|
J Cardiovasc Transl Res
|
2012
|
0.85
|
|
39
|
Metabolic stress in the myocardium: adaptations of gene expression.
|
J Mol Cell Cardiol
|
2012
|
0.84
|
|
40
|
SmD3 regulates intronic noncoding RNA biogenesis.
|
Mol Cell Biol
|
2012
|
0.83
|
|
41
|
The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.
|
J Lipid Res
|
2003
|
0.82
|
|
42
|
Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects.
|
Ultrasound Med Biol
|
2009
|
0.81
|
|
43
|
Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum.
|
Ultrasound Med Biol
|
2010
|
0.80
|
|
44
|
Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma.
|
Anal Bioanal Chem
|
2013
|
0.79
|
|
45
|
Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.
|
J Biol Chem
|
2013
|
0.79
|
|
46
|
ApoA-1 in diabetes: damaged goods.
|
Diabetes
|
2010
|
0.77
|
|
47
|
Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects.
|
Ultrasound Med Biol
|
2011
|
0.75
|
|
48
|
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
|
J Clin Invest
|
2016
|
0.75
|